Review
Clinical Neurology
John J. Halperin, Randi Eikeland, John A. Branda, Rick Dersch
Summary: Lyme borreliosis affects the nervous system in various ways, but there are many misunderstandings and misattributions that need to be clarified through further research and diagnosis. Gaps still exist in our understanding of this disease, and basic pathophysiological principles are needed to eliminate controversies.
Review
Cell Biology
Scott Ayton, Ashley Bush
Summary: Alzheimer's disease is a major disease without preventative or disease modifying therapy, and current drugs targeting amyloid beta have been unsuccessful in slowing cognitive decline. Debate is ongoing about whether to continue anti-A beta therapy or pursue alternative targets. The need for disease modifying AD therapies has become one of the highest priorities in all of medicine due to the growing burden of the disease on patients, families, and healthcare budgets.
AGEING RESEARCH REVIEWS
(2021)
Review
Cardiac & Cardiovascular Systems
Lauren K. Barron, Marc R. Moon
Summary: This review summarizes the recent evidence and existing recommendations for secondary prevention in patients after coronary artery bypass grafting (CABG). The recommendations for medical therapy are mainly based on large-scale randomized controlled trials and meta-analyses, but important characteristics of the surgical patients are often omitted, making it challenging to provide universal recommendations for all CABG patients.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Hagai Abeliovich
Summary: Mitophagy, the autophagic breakdown of mitochondria, plays vital roles in respiring eukaryotic cells. It can be categorized into quality control mitophagy and developmentally induced mitophagy. Although more studies have been done on mitophagy in mammalian cells, our understanding of mitophagy in yeast is still limited.
BIOCHEMICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
A. Cristina Barragan, Detlef Weigel
Summary: Plants and pathogens constantly adapt to each other, leading to a high level of diversity among NLRs in the plant immune system. With comprehensive pan-genome and pan-NLRome studies, our understanding of NLR sequence diversity is rapidly growing, providing a powerful platform for assigning NLR function.
Review
Plant Sciences
Sarah Rottet, Britta Forster, Wei Yih Hee, Loraine M. M. Rourke, G. Dean Price, Benedict M. M. Long
Summary: The study discusses the challenges and engineering strategies for synthesizing a biophysical CO2-concentrating mechanism in plant chloroplasts, focusing on key issues in regulating HCO3- transporters and CO2-to-HCO3- converters.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Cell Biology
Yanqing Liu, Xuezeng Xu, Wangrui Lei, Yuxuan Hou, Yan Zhang, Ran Tang, Zhi Yang, Ye Tian, Yanli Zhu, Changyu Wang, Chao Deng, Shaofei Zhang, Yang Yang
Summary: This review discusses the roles of NLRP3 in fibrosis and aging, and highlights the potential of targeting NLRP3 as a therapeutic approach for anti-fibrosis and anti-aging.
AGEING RESEARCH REVIEWS
(2022)
Review
Multidisciplinary Sciences
Sabarinath Peruvemba Subramanian, Rebekah L. Gundry
Summary: Apolipoprotein glycosylation plays a crucial role in its function and disease manifestation. However, the complete glycan repertoire of most apolipoproteins remains unknown. This review provides an overview of the current understanding and knowledge gaps regarding human apolipoprotein glycan composition, structure, glycosylation site, and functions. Future research on apolipoprotein glycosylation is expected to contribute to the discovery of disease processes, biomarkers, and therapeutic targets.
Article
Neurosciences
Elena Antelmi, Lorenzo Rocchi, Anna Latorre, Daniele Belvisi, Francesca Magrinelli, Kailash P. Bhatia, Michele Tinazzi
Summary: Although restless legs syndrome (RLS) is a common neurological disorder, it is poorly understood from a clinical and pathophysiological perspective. However, based on several lines of evidence, it is proposed that RLS should be seen as a disorder of sensorimotor interaction with a typical circadian pattern of occurrence.
Review
Microbiology
Rebecca A. Ward, George R. Thompson, Alexandra-Chloe Villani, Bo Li, Michael K. Mansour, Marcel Wuethrich, Jenny M. Tam, Bruce S. Klein, Jatin M. Vyas
Summary: Coccidioidomycosis, or Valley Fever, is caused by dimorphic fungi Coccidioides immitis and C. posadasii. While most cases present with self-limiting pulmonary infection, dissemination of the fungi can lead to higher mortality rates. The immunological mechanisms underlying clearance or containment of the infection in the lungs are still poorly understood.
Review
Cardiac & Cardiovascular Systems
Ilaria Secco, Mauro Giacca
Summary: Myocardial regeneration in patients with cardiac damage is an important goal in clinical medicine. Understanding the mechanisms of cardiomyocyte proliferation and delivery of pro-regenerative factors to the heart are key challenges in progressing cardiac regenerative therapies.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Business
Mario L. D. Jose, Fernando A. F. Ferreira, Constantin Zopounidis, Michalis Doumpos, Neuza C. M. Q. F. Ferreira
Summary: Due to an aging population, the over-50 segment in Europe has increased significantly, giving rise to the silver economy. However, technological innovation targeted at this market has exacerbated social disparities, resulting in digital inequality. This study addresses the challenges of reducing digital inequalities in the silver economy by adopting a constructivist approach and combining cognitive mapping and decision-making trial and evaluation laboratory techniques. After analyzing different strategies, the study provides recommendations for initiatives that increase digital literacy in this context.
IEEE TRANSACTIONS ON ENGINEERING MANAGEMENT
(2023)
Review
Infectious Diseases
Jeroen Schouten, Jan De Waele, Christian Lanckohr, Despoina Koulenti, Nisrine Haddad, Nesrine Rizk, Fredrik Sjovall, Souha S. Kanj
Summary: Issues surrounding antimicrobial stewardship in the context of COVID-19 patients include the challenge of distinguishing between infectious and non-infectious causes of respiratory deterioration, the relevance of biomarkers like procalcitonin, the consideration of cytomegalovirus reactivation, and the complexities in diagnosing COVID-19-associated invasive aspergillosis. Additionally, there is a need to take into account altered pharmacokinetic/pharmacodynamic properties when prescribing antimicrobial therapy in this population, emphasizing the importance of further research to address unknowns in this area.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Review
Pharmacology & Pharmacy
David Cavalla, Gamal Crichton
Summary: DrugRepurposing Online is a curated database for literature examples of repurposed drugs, organized by compounds and indications, using a generalization layer of mechanism within specific datasets. References are categorized by relevance to human application, aiding users in prioritizing repurposing hypotheses. Users can freely search between any two categories and expand results to the third category. By combining direct relationships, novel and non-obvious opportunities for repurposing can be created, which can be patented and efficiently developed. Natural language processing enables further opportunities beyond the hand-curated foundation.
DRUG DISCOVERY TODAY
(2023)
Review
Biochemistry & Molecular Biology
Lei Qui, Xinyu He, Qian Tang, Xiao Fan, Jian Liu, Aifu Lin
Summary: This review summarizes the associations among iron metabolism, ferroptosis, and ferroptosis-related long noncoding RNA (lncRNA) in tumorigenesis. It provides insights into the role of lncRNA in iron metabolism and raises the possibility of targeting lncRNA and ferroptosis in cancer combination therapy.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)