Article
Chemistry, Multidisciplinary
Yafang Guo, Andrea Baschieri, Fabio Mollica, Luca Valgimigli, Jakub Cedrowski, Grzegorz Litwinienko, Riccardo Amorati
Summary: Research demonstrates that polydopamine exhibits excellent antioxidant activity by trapping alkylperoxyl radicals through reducing ortho-quinone moieties. This reaction occurs via a hydrogen atom transfer mechanism, as evidenced by the kinetic solvent effect observed in model quinone reactions with hydroperoxyl radicals. This discovery aids in understanding the redox-mediated bioactivity of melanins and quinones.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Luca Valgimigli
Summary: This article reviews the chemistry and biological consequences of lipid peroxidation, focusing on the kinetics of different processes and the efficacy of antioxidant strategies. The main types of antioxidants, their mechanisms, kinetics, and potential role in modulating ferroptosis are discussed, along with the latest unconventional antioxidant strategies based on the double-sided role of the superoxide/hydroperoxyl radical system.
Article
Biochemistry & Molecular Biology
Xiaoxia Yao, Jilong Zhang, Yifei Zhu
Summary: The concerted elimination reaction class of peroxyl-hydroperoxyl alkyl radicals plays a crucial role in low-temperature combustion. By dividing reactions into subclasses and calculating energy barriers, accurate rate constants and rules are obtained to aid in constructing more accurate combustion mechanisms.
Article
Chemistry, Organic
Ron Shah, Jia-Fei Poon, Evan A. Haidasz, Derek A. Pratt
Summary: This study found that there is an optimal alkyl substitution compromise between reactivity and stability for alkylated diphenylamines RTAs at high temperatures. The structure-activity relationships differ dramatically with temperature, with para-alkyl substitution slightly increasing reactivity and stoichiometry while ortho-alkyl substitution slightly decreasing both. These findings provide insights into enhancing the efficacy of high-temperature RTAs.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Julian Helberg, Derek A. Pratt
Summary: Autoxidation limits the longevity of hydrocarbons and materials by leading to complex mixtures of compounds that alter their physical properties. Antioxidants can inhibit this process by intervening directly in the chain reaction. Understanding the mechanistic considerations of autoxidation is important across various contexts.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Sabina Sacirovic, Jelena Dorovic Jovanovic, Dusan Dimic, Zorica Petrovic, Dusica Simijonovic, Nedeljko Manojlovic, Malisa Antic, Zoran Markovic
Summary: This study analyzed the antioxidant activity and phenolic compound content of Serbian wines, correlating it with specific polyphenols and discussing the origin of the antioxidant potential. Thermodynamic parameters of free radical scavenging activities and reactivity were explained, emphasizing the effect of structure and intramolecular interactions in polyphenols. The research concluded the positive effects of selected Serbian wines on human health and biologically relevant free radicals.
MONATSHEFTE FUR CHEMIE
(2021)
Article
Biochemistry & Molecular Biology
Elisabetta Damiani, Raif Yuecel, Heather M. Wallace
BIOCHEMICAL JOURNAL
(2019)
Review
Biochemistry & Molecular Biology
Andrea Scire, Laura Cianfruglia, Cristina Minnelli, Desiree Bartolini, Pierangelo Torquato, Giovanni Principato, Francesco Galli, Tatiana Armeni
Review
Chemistry, Medicinal
Elisabetta Damiani, Carmelo Puglia
JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Food Science & Technology
Andrea Scire, Fabio Tanfani, Alessio Ausili
Article
Biochemistry & Molecular Biology
Laura Cianfruglia, Cristina Minnelli, Emiliano Laudadio, Andrea Scire, Tatiana Armeni
Article
Biochemistry & Molecular Biology
Elena Ferrari, Romina Corsini, Samuele E. Burastero, Fabio Tanfani, Alberto Spisni
MOLECULAR IMMUNOLOGY
(2020)
Article
Food Science & Technology
Magdalena Muller, Dalene De Beer, Cristina Truzzi, Anna Annibaldi, Patricia Carloni, Federico Girolametti, Elisabetta Damiani, Elizabeth Joubert
LWT-FOOD SCIENCE AND TECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ilenia Cirilli, Patrick Orlando, Fabio Marcheggiani, Phiwayinkosi V. Dludla, Sonia Silvestri, Elisabetta Damiani, Luca Tiano
Review
Biochemistry & Molecular Biology
Phiwayinkosi Dludla, Bongani B. Nkambule, Sithandiwe E. Mazibuko-Mbeje, Tawanda M. Nyambuya, Fabio Marcheggiani, Ilenia Cirilli, Khanyisani Ziqubu, Samukelisiwe C. Shabalala, Rabia Johnson, Johan Louw, Elisabetta Damiani, Luca Tiano
Review
Biochemistry & Molecular Biology
Lidia de Bari, Andrea Scire, Cristina Minnelli, Laura Cianfruglia, Miklos Peter Kalapos, Tatiana Armeni
Summary: The balance between ROS and MGO metabolism is crucial for maintaining redox homeostasis and biological functions in cells, preventing oxidative damage. Changes in GSH and MGO levels under different conditions can impact cell responses and signaling pathways.
Review
Medicine, General & Internal
Matteo Giulietti, Monia Cecati, Berina Sabanovic, Andrea Scire, Alessia Cimadamore, Matteo Santoni, Rodolfo Montironi, Francesco Piva
Summary: Studies have shown that AI-based predictors for renal cancer diagnosis and prognosis have slightly better performance compared to non-AI-based predictors, with only minor improvements in accuracy and AUC over the last decade. Different studies with the same goal achieve similar performance despite using different discriminating genes.
Article
Food Science & Technology
Luisa Bellachioma, Gabriele Rocchetti, Camilla Morresi, Erika Martinelli, Luigi Lucini, Gianna Ferretti, Elisabetta Damiani, Tiziana Bacchetti
Summary: The aim of this study was to evaluate the functional and sensory traits of infusions from different brewing processes and saffron flower portions. Tepals showed higher polyphenol and flavonoid content compared to stamen infusions, and their content depended more on brewing temperature. Multivariate statistics highlighted polyphenols discriminating different brewing processes. Cold brewing successfully extracted phenolic compounds and provided better sensory properties.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrea Scire, Laura Cianfruglia, Cristina Minnelli, Brenda Romaldi, Emiliano Laudadio, Roberta Galeazzi, Cinzia Antognelli, Tatiana Armeni
Summary: Glyoxalase 2, a crucial enzyme in the glyoxalase pathway, plays a significant role in cell detoxification and is increasingly recognized for its involvement in oxidative stress and other regulatory pathways.
Review
Biochemistry & Molecular Biology
Andrea Scire, Giulia Casari, Brenda Romaldi, Lidia de Bari, Cinzia Antognelli, Tatiana Armeni
Summary: This review provides information on the S-glutathionylation of hemoglobin and its impact on functionality, and highlights HbSSG as an emerging indicator of oxidative stress and a key pathogenic factor in various diseases.
Review
Oncology
Elisabetta Damiani, Munevver N. Duran, Nivedhitha Mohan, Praveen Rajendran, Roderick H. Dashwood
JOURNAL OF CANCER PREVENTION
(2020)
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)