Review
Oncology
Jacek Baj, James Curtis Dring, Marcin Czeczelewski, Pawel Kozyra, Alicja Forma, Jolanta Flieger, Beata Kowalska, Grzegorz Buszewicz, Grzegorz Teresinski
Summary: Micro- and nanoplastic particles pose a significant threat to human health, potentially leading to the development of various types of cancers. Extensive research has been conducted to investigate the effects of exposure to these substances, revealing a clear correlation between micro- and nanoplastic exposure and the onset of several cancers.
Article
Cell Biology
Serena Dato, Francesco De Rango, Paolina Crocco, Stefano Pallotti, Michael E. Belloy, Yann Le Guen, Michael D. Greicius, Giuseppe Passarino, Giuseppina Rose, Valerio Napolioni
Summary: Advanced age is the biggest risk factor for late-onset Alzheimer's disease (LOAD), with shared genetic signatures between LOAD and longevity. Gene-gene interactions in pathways related to insulin/IGF1 signaling, DNA repair, and oxidative stress were found to affect LOAD. These findings suggest that risk factor interactions may drive different trajectories of cognitive aging.
Article
Cell Biology
Serena Dato, Francesco De Rango, Paolina Crocco, Stefano Pallotti, Michael E. Belloy, Yann Le Guen, Michael D. Greicius, Giuseppe Passarino, Giuseppina Rose, Valerio Napolioni
Summary: Advanced age is the biggest risk factor for late-onset Alzheimer's disease (LOAD), and it shares genetic signatures with longevity. The study found evidence that pathways leading to longevity also contribute to LOAD, and identified interacting genes that are associated with survival to old age. The findings suggest that interactions of risk factors may drive different trajectories of cognitive aging.
Article
Transplantation
Sander Groen In 't Woud, Marleen M. H. J. van Gelder, Iris A. L. M. van Rooij, Wout F. J. Feitz, Nel Roeleveld, Michiel F. Schreuder, Loes F. M. van der Zanden
Summary: Congenital solitary functioning kidney is associated with hypertension, albuminuria, and chronic kidney disease. The study found that interactions between genetic and environmental factors, such as a specific gene mutation in conjunction with maternal overweight, may contribute to the etiology of CSFK. Further research is needed to explore these interactions and their potential impact on the development of the condition.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Cell & Tissue Engineering
Marcus A. Florez, Brandon T. Tran, Trisha K. Wathan, James DeGregori, Eric M. Pietras, Katherine Y. King
Summary: Clonal hematopoiesis of indeterminate potential (CHIP) refers to the expansion of genetically variant hematopoietic cells, which increases with age and is associated with environmental factors such as infections, chemotherapy, and smoking. Understanding how these environmental contexts alter tissue microenvironments to facilitate the selection and expansion of specific CHIP mutant clones, as well as identifying remaining gaps in knowledge, will have implications for transplant and preventive medicine.
Article
Gastroenterology & Hepatology
Nan Ru, Xiao-Nan Xu, Yu Cao, Jia-Hui Zhu, Liang-Hao Hu, Sheng-Yong Wu, Yang-Yang Qian, Jun Pan, Wen-Bin Zou, Zhao-Shen Li, Zhuan Liao
Summary: This study conducted a research on a large cohort of chronic pancreatitis patients and found that alcohol consumption and smoking are closely related to the development of pancreatic insufficiency. However, rare pathogenic gene mutations did not show significant correlation with pancreatic insufficiency.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Immunology
Oyebola O. Oyesola, Camila Oliveira Silva Souza, P'ng Loke
Summary: Helminth infections affect over 2 billion people worldwide, with host genetics and environmental factors playing critical roles in regulating immune responses. Studying the interactions between environment and genetic factors in helminth infections could lead to the development of new preventive and therapeutic options.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Melinda R. Grosser, Samantha K. Sites, Mayara M. Murata, Yolanda Lopez, Karen C. Chamusco, Kyra Love Harriage, Jude W. Grosser, James H. Graham, Fred G. Gmitter, Christine D. Chase
Summary: Plant genomes contain nuclear, plastid, and mitochondrial components which have different inheritance and evolutionary patterns. Genetic markers from these three genomes can be used to study inheritance, genetic relationships, and phenotypic contributions. Developing mitochondrial markers is challenging due to their high variability in size, gene order, and non-coding sequences, as well as their conservation in protein-coding sequences. PCR amplification of introns using conserved flanking exons is an effective method for developing polymorphic nuclear genome markers.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yanmei Wu, Zibo Lin, Meihua Luo, Xinfa Yu, Sidong Chen, Li Liu
Summary: The study identified associations between certain SNPs of the INTS10 gene and the risk of HBV-related HCC. Patients in the highest tertile of the genetic risk score had an increased risk compared to those in the lowest tertile, and drinking may exacerbate this risk.
MOLECULAR CARCINOGENESIS
(2021)
Article
Health Care Sciences & Services
Pablo Perez-Moreno, Ismael Riquelme, Patricia Garcia, Priscilla Brebi, Juan Carlos Roa
Summary: Gallbladder cancer is an aggressive neoplasm that is often asymptomatic in early stages and is typically diagnosed at an advanced stage. The presence of gallstones is the main risk factor, while other factors such as inflammation can also contribute to the development of gallbladder cancer. Understanding the early carcinogenic mechanisms is crucial for prevention.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, Research & Experimental
Li Wang, Wangyang Liu, Kailai Liu, Lixia Wang, Xiangzhe Yin, Lin Bo, Haotian Xu, Shihua Lin, Ke Feng, Xinyu Zhou, Lin Lin, Meiting Fei, Caiyu Zhang, Shangwei Ning, Hongying Zhao
Summary: In this study, the researchers conducted a single-cell transcriptome analysis to investigate the dynamic gene regulation and molecular mechanism driving lung adenocarcinoma (LUAD) progression. They identified stage-specific risk genes and constructed a dysregulated network to understand the changes in gene regulation during LUAD progression. Additionally, they identified several genes as prognostic markers in LUAD.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Genetics & Heredity
Qing Sang, Zhou Zhou, Jian Mu, Lei Wang
Summary: This review outlines the genetic determinants of abnormalities in human oocyte maturation, fertilization, and early embryonic development, identifying 16 genes that may cause oocyte maturation arrest, fertilization failure, and embryonic lethality. These genetic markers lay the foundation for individualized genetic counseling and potential treatments in reproductive medicine.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Agronomy
Benmeng Liang, Yuhetian Zhao, Yabin Pu, Xiaohong He, Jiangang Han, Baima Danzeng, Yuehui Ma, Jianfeng Liu, Lin Jiang
Summary: Through the analysis of 448 individuals from 24 Tibetan sheep populations in different regions, we successfully constructed specific SNP genetic marker sets for the identification of Tibetan sheep breeds at the molecular level, including Yunnan-Tibetan sheep, Zuogong, Heizang, Gongga, and Tao sheep.
Article
Obstetrics & Gynecology
Lei Li, Guangyi Zhao, Jie Wu, Haiyu Pang, Tianli Zhang, Juan Chen, Kunlin Zhang, Lan Zhu
Summary: This study aims to investigate the interactions between genetic variants and environmental risk factors in pelvic organ prolapse (POP) and to identify SNPs that may interact with maximum birth weight and age in Chinese women. The results showed that several SNPs interacted with maximum birth weight and age on POP severity. The findings suggest the potential use of combining epidemiologic exposure data with selected genotyping for risk assessment and patient stratification.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Agronomy
Zsuzsanna Gyorgy, Sameena Alam, Priyanka Priyanka, Eva Zamborine Nemeth
Summary: This study assessed the genetic diversity of 58 opium poppy accessions using SSR markers. The findings showed low genetic diversity among the opium poppy accessions, and the markers were unable to distinguish genotypes based on geographical origin or seed color. However, grouping based on alkaloid content and petal color was observed.
