The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Monitoring Gq-coupled receptor response through inositol phosphate quantification with the IP-One assay

(2011) Eric Trinquet et al.   Expert Opinion on Drug Discovery

Non-activated APJ suppresses the angiotensin II type 1 receptor, whereas apelin-activated APJ acts conversely

(2011) Xiao Sun et al.   HYPERTENSION RESEARCH

Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production

(2011) Khandaker Siddiquee et al.   JOURNAL OF HYPERTENSION

Validation of genetic association in apelin–AGTRL1 system with hypertension in a larger Han Chinese population

(2010) Wenquan Niu et al.   JOURNAL OF HYPERTENSION

Sequence-Derived Three-Dimensional Pharmacophore Models for G-Protein-Coupled Receptors and Their Application in Virtual Screening

(2009) Thomas Klabunde et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

(2009) Yang Han et al.   Nature Chemical Biology

The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways

(2009) Xavier Rovira et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

(2008) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

How and why do GPCRs dimerize?

(2008) Vsevolod V. Gurevich et al.   TRENDS IN PHARMACOLOGICAL SCIENCES