Journal
NEUROSCIENCE LETTERS
Volume 445, Issue 1, Pages 12-17Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.08.073
Keywords
Synphilin-1; Parkinson's disease; Transgenic mice; Tyrosine hydroxylase; alpha-Synuclein
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Funding
- Japanese Ministry of Education, Culture, Sports, Science, and Technology
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Synphilin-1 represents a cytoplasmic protein that interacts with (x-synuclein and localizes close to synaptic vesicles. The interaction of synphilin-1 with several proteins involved in Parkinson's disease suggests that it might be involved in the pathogenesis of the disease. Nonetheless, the function of synphilin-1 remains unclear. In the present study, we generated transgenic mice expressing human synphilin-1 under the prion protein promoter. Synphilin-1 was widely expressed in neurons in the brain including the substantia nigra, where massive loss of dopamine neurons was not observed. In the transgenic Mouse brain, synphilin-1 protein was polyubiquitinated, and partially insoluble. Although modified-SHIRPA revealed no significant difference in behavior and morphology, the reduced rotarod performance and step length were observed in transgenic mice as compared with non-transgenic littermates. Synphilin-l might be involved in motor function, and its accumulation in the central nervous system can cause motor impairments. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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