Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing

Trop2: From development to disease

(2015) Annie R.A. McDougall et al.   DEVELOPMENTAL DYNAMICS

Conformation-Dependent Epitopes Recognized by Prion Protein Antibodies Probed Using Mutational Scanning and Deep Sequencing

(2015) Kyle M. Doolan et al.   JOURNAL OF MOLECULAR BIOLOGY

Precise and Efficient Antibody Epitope Determination through Library Design, Yeast Display and Next-Generation Sequencing

(2015) Thomas Van Blarcom et al.   JOURNAL OF MOLECULAR BIOLOGY

High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome

(2015) Veronica C. Casina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody specific epitope prediction—emergence of a new paradigm

(2015) Inbal Sela-Culang et al.   Current Opinion in Virology

High-Resolution Sequence-Function Mapping of Full-Length Proteins

(2015) Caitlin A. Kowalsky et al.   PLoS One

Proof of principle for epitope-focused vaccine design

(2014) Bruno E. Correia et al.   NATURE

The promise and challenge of high-throughput sequencing of the antibody repertoire

(2014) George Georgiou et al.   NATURE BIOTECHNOLOGY

Deep mutational scanning: a new style of protein science

(2014) Douglas M Fowler et al.   NATURE METHODS

High-resolution antibody dynamics of vaccine-induced immune responses

(2014) Uri Laserson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping of the Binding Landscape for a Picomolar Protein-Protein Complex through Computation and Experiment

(2014) Yonatan Aizner et al.   STRUCTURE

Crystal structure and its bearing towards an understanding of key biological functions of EpCAM

(2014) Miha Pavšič et al.   Nature Communications

Quantitative, solution-phase profiling of multiple transcription factors in parallel

(2013) Betul Bilgin et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A multi-layer inference approach to reconstruct condition-specific genes and their regulation

(2013) Ming Wu et al.   BIOINFORMATICS

Structural Basis for Treating Tumor Necrosis Factor α (TNFα)-associated Diseases with the Therapeutic Antibody Infliximab

(2013) Shuaiyi Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

IPAF inflammasome is involved in interleukin-1β production from astrocytes, induced by palmitate; implications for Alzheimer's Disease

(2013) Li Liu et al.   NEUROBIOLOGY OF AGING

Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons

(2013) Sachin P. Patil et al.   NEUROSCIENCE LETTERS

Biochemical and preliminary X-ray characterization of the tumor-associated calcium signal transducer 2 (Trop2) ectodomain

(2013) Tilen Vidmar et al.   PROTEIN EXPRESSION AND PURIFICATION

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

(2013) J. S. McLellan et al.   SCIENCE

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Antibody Repertoire Profiling Using Bacterial Display Identifies Reactivity Signatures of Celiac Disease

(2012) Bradley N. Spatola et al.   ANALYTICAL CHEMISTRY

Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via  -catenin signaling

(2012) T. Stoyanova et al.   GENES & DEVELOPMENT

Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast

(2012) Jordi Mata-Fink et al.   JOURNAL OF MOLECULAR BIOLOGY

Mapping of discontinuous conformational epitopes by amide hydrogen/deuterium exchange mass spectrometry and computational docking

(2012) Deepangi Pandit et al.   JOURNAL OF MOLECULAR RECOGNITION

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

(2012) Timothy A Whitehead et al.   NATURE BIOTECHNOLOGY

Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases

(2012) Li Liu et al.   NEUROBIOLOGY OF AGING

PFunkel: Efficient, Expansive, User-Defined Mutagenesis

(2012) Elad Firnberg et al.   PLoS One

Identification of novel targets for breast cancer by exploring gene switches on a genome scale

(2011) Ming Wu et al.   BMC GENOMICS

Rep-Seq: uncovering the immunological repertoire through next-generation sequencing

(2011) Jennifer Benichou et al.   IMMUNOLOGY

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

(2011) S. J. Fleishman et al.   SCIENCE

cAMP initiates early phase neuron-like morphology changes and late phase neural differentiation in mesenchymal stem cells

(2010) Linxia Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Global, regional, and national causes of child mortality in 2008: a systematic analysis

(2010) Robert E Black et al.   LANCET

Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination

(2010) C.-J. Wei et al.   SCIENCE

Characterization of a Key Neutralizing Epitope on Pertussis Toxin Recognized by Monoclonal Antibody 1B7

(2009) Jamie N. Sutherland et al.   BIOCHEMISTRY

Nuclear signalling by tumour-associated antigen EpCAM

(2009) Dorothea Maetzel et al.   NATURE CELL BIOLOGY

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High expression of TROP2 correlates with poor prognosis in pancreatic cancer

(2008) D Fong et al.   BRITISH JOURNAL OF CANCER

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One