Streptozotocin Stimulates the Ion Channel TRPA1 Directly

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

(2015) Mirjam Eberhardt et al.   Nature Communications

Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

(2014) Lavanya Moparthi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Methylglyoxal Evokes Pain by Stimulating TRPA1

(2013) David A. Andersson et al.   PLoS One

Is diabetes an acquired disorder of reactive glucose metabolites and their intermediates?

(2012) T. Fleming et al.   DIABETOLOGIA

Streptozotocin-Induced Cytotoxicity, Oxidative Stress and Mitochondrial Dysfunction in Human Hepatoma HepG2 Cells

(2012) Haider Raza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1)

(2012) Mirjam J. Eberhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells

(2012) De-Shou Cao et al.   PLoS One

Protection from diabetes-induced peripheral sensory neuropathy — A role for elevated glyoxalase I?

(2011) M.M. Jack et al.   EXPERIMENTAL NEUROLOGY

TRPA1 and Substance P Mediate Colitis in Mice

(2011) Matthias A. Engel et al.   GASTROENTEROLOGY

Comparative studies on manganese-based SOD mimetics, including the phosphate effect, by using global spectral analysis

(2011) Felix C. Friedel et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Streptozotocin-Induced Early Thermal Hyperalgesia is Independent of Glycemic State of Rats: Role of Transient Receptor Potential Vanilloid 1(TRPV1) and Inflammatory Mediators

(2011) Mahendra Bishnoi et al.   Molecular Pain

Diabetic neuropathy: cellular mechanisms as therapeutic targets

(2011) Andrea M. Vincent et al.   Nature Reviews Neurology

Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: Sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy

(2011) Ari Koivisto et al.   PHARMACOLOGICAL RESEARCH

TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol

(2011) David A Andersson et al.   Nature Communications

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators

(2010) Nobuaki Takahashi et al.   Channels

The Roles of iPLA2, TRPM8 and TRPA1 in Chemically Induced Cold Hypersensitivity

(2010) Clive Gentry et al.   Molecular Pain

Attenuation of Mechanical Hypersensitivity by an Antagonist of the TRPA1 Ion Channel in Diabetic Animals

(2009) Hong Wei et al.   ANESTHESIOLOGY

Streptozotocin-induced mechanical hypernociception is not dependent on hyperglycemia

(2009) J.M. Cunha et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Diabetic painful and insensate neuropathy: Pathogenesis and potential treatments

(2009) Irina G. Obrosova   Neurotherapeutics

Selective Targeting of TRPV1 Expressing Sensory Nerve Terminals in the Spinal Cord for Long Lasting Analgesia

(2009) Joseph A. Jeffry et al.   PLoS One

Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+

(2009) D. A. Andersson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain

(2008) Shenglan Wang et al.   BRAIN

Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress

(2008) Kerstin Hill et al.   CELL CALCIUM

Role of Advanced Glycation End Products in Diabetic Neuropathy

(2008) Kazuhiro Sugimoto et al.   CURRENT PHARMACEUTICAL DESIGN

TRPA1 is a major oxidant sensor in murine airway sensory neurons

(2008) Bret F. Bessac et al.   JOURNAL OF CLINICAL INVESTIGATION

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

Diabetic neuropathy: Mechanisms to management

(2008) James L. Edwards et al.   PHARMACOLOGY & THERAPEUTICS

Glucose neurotoxicity

(2007) David R. Tomlinson et al.   NATURE REVIEWS NEUROSCIENCE