Article
Urology & Nephrology
Jennifer S. Y. Li, Harry Robertson, Katie Trinh, Arti M. Raghubar, Quan Nguyen, Nicholas Matigian, Ellis Patrick, Angus W. Thomson, Andrew J. Mallett, Natasha M. Rogers
Summary: Ischemia reperfusion injury is a common cause of acute kidney injury. Adoptively transferred tolerogenic dendritic cells can successfully limit kidney injury and provide protection against ischemia reperfusion injury.
KIDNEY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Heng-Chih Pan, Yau-Hung Chen, Wei-Ching Fang, Vin-Cent Wu, Chiao-Yin Sun
Summary: KDM4C plays a critical role in kidney development and acute kidney injury (AKI). Knockdown of KDM4C leads to impaired kidney development and decreased cell survival in zebrafish and mouse models. Furthermore, KDM4C may exert a protective effect on cell survival in AKI by regulating mitochondrial dynamics and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Benedikt Kolbrink, Friedrich Alexander von Samson-Himmelstjerna, Maja Lucia Messtorff, Theresa Riebeling, Raphael Nische, Jessica Schmitz, Jan Hinrich Brasen, Ulrich Kunzendorf, Stefan Krautwald
Summary: Ferroptosis, a type of iron-dependent programmed cell death, plays a vital role in multiple diseases. However, there are no pharmacologic inhibitors of ferroptosis in clinical use. In this study, vitamin K1 was identified as an efficient inhibitor of ferroptosis, providing a new strategy for pharmacological control of this mode of cell death.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Engineering, Biomedical
Weimin Tang, Sudipta Panja, Chinmay M. Jogdeo, Siyuan Tang, Ling Ding, Ao Yu, Kirk W. Foster, Del L. Dsouza, Yashpal S. Chhonker, Heather Jensen-Smith, Hee-Seong Jang, Erika I. Boesen, Daryl J. Murry, Babu Padanilam, David Oupicky
Summary: This study demonstrates the synthesis of a novel siRNA carrier, C-CS, which shows potential for targeted delivery to injured kidneys. The C-CS/siRNA nanoparticles effectively accumulate and deliver therapeutic siRNAs to injured kidneys through CXCR4 binding, providing a new approach for AKI therapy.
Article
Cell Biology
Izumi Nagayama, Kaori Takayanagi, Hajime Hasegawa, Akito Maeshima
Summary: In this study, the expression and localization of follistatin in normal and ischemic rat kidneys were examined, and urinary follistatin levels were measured to assess its potential as a biomarker for acute kidney injury. The results showed that follistatin was mainly localized in the distal tubules of the cortex in normal kidneys, while it was also present in the distal tubules of both the cortex and outer medulla in ischemic kidneys. Urinary follistatin levels were significantly increased in ischemic rats and correlated with the duration of ischemia, the follistatin-positive area, and the acute tubular damage area.
Article
Biochemistry & Molecular Biology
Johanna Stoermer, Wilfried Gwinner, Katja Derlin, Stephan Immenschuh, Song Rong, Mi-Sun Jang, Nelli Shushakova, Hermann Haller, Faikah Gueler, Robert Greite
Summary: This study investigated the effects of diclofenac on the progression of AKI and long-term renal consequences in the setting of pre-existing subclinical AKI. The results showed that diclofenac aggravated renal injury in a dose and time-dependent manner and even a single dose can cause progression to chronic kidney disease.
Article
Immunology
Jiefu Zhu, Yafei Zhang, Lang Shi, Yao Xia, Hongchu Zha, Huimin Li, Zhixia Song
Summary: This study reveals the protective role of RP105 in ischemic and septic acute kidney injury (AKI). Overexpression of RP105 alleviated renal structural injuries and dysfunction caused by ischemic and septic AKI. RP105 suppressed inflammatory responses mediated by the TLR4 signaling pathway. These findings suggest that RP105 could be a potential target for preventing and treating ischemic and septic AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Lijuan Ma, Xueqi Liu, Mengya Zhang, Lang Zhou, Ling Jiang, Li Gao, Xian Wang, Yuebo Huang, Hanxu Zeng, Yonggui Wu
Summary: This article discusses the complicated pathophysiological mechanism of acute kidney injury (AKI) and the lack of effective drugs. It also introduces a newly discovered cell death mode called ferroptosis, which is involved in the progression of AKI. Paeoniflorin (PF), a traditional Chinese medicine, has protective effects on kidney diseases including AKI, but the mechanism of PF in attenuating AKI is unclear.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chih-Chao Yang, Pei-Hsun Sung, John Y. Chiang, Han-Tan Chai, Chih-Hung Chen, Yi-Ching Chu, Yi-Chen Li, Hon-Kan Yip
Summary: Combined tacrolimus and melatonin therapy was more effective than either single treatment in protecting the kidney from IR injury by suppressing inflammation and oxidative stress.
Article
Nanoscience & Nanotechnology
Chenguang Ding, Bo Wang, Jin Zheng, Mingzhen Zhang, Yang Li, Hsin-Hui Shen, Yingcong Guo, Bingxuan Zheng, Puxun Tian, Xiaoming Ding, Wujun Xue
Summary: Ischemia/reperfusion (I/R) injury leads to excessive oxidative events and destructive inflammatory responses, playing a key role in various pathological conditions. Ferroptosis, a type of iron-dependent nonapoptotic cell death, is associated with I/R injury diseases. Excessive production of inflammatory cytokines contributes to the development of acute kidney injury. In this study, neutrophil membrane-coated copper-based nanoparticles (N-Cu5.4O@DFO NPs) demonstrated excellent antioxidant and iron ion scavenging abilities, effectively reducing oxidative damage and inflammatory response in the kidney, presenting a potential therapeutic strategy for renal I/R injury. This work also promotes the development of nanoantioxidant agents for the treatment of other I/R injury diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Jiajia Li, Yupeng Jiang, Qin Dai, Yue Yu, Xin Lv, Yan Zhang, Xiaohua Liao, Liyun Ao, Gaoyun Hu, Jie Meng, Zhangzhe Peng, Lijian Tao, Yanyun Xie
Summary: In this study, the protective effect of Mefunidone on ischemia-reperfusion injury-induced acute kidney injury was investigated. The results showed that Mefunidone can protect the kidney by relieving kidney tubular injury, suppressing oxidative stress, and inhibiting cell apoptosis. Furthermore, Mefunidone reduced mitochondrial damage and protected mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Xishao Xie, Yunjing Zhang, Xinwan Su, Junni Wang, Xi Yao, Dou Lv, Qin Zhou, Jianhua Mao, Jianghua Chen, Fei Han, Yangyang Li, Weiqiang Lin
Summary: This study synthesized gallic acid-gallium polyvinyl pyrrolidone nanoparticles (GGP NPs) as a potential iron-scavenging agent and demonstrated their good biocompatibility and protective effects in inhibiting ferroptosis. Treatment with GGP NPs significantly ameliorated renal injury and mitochondrial damage, making them a potential candidate for AKI treatment.
Article
Pharmacology & Pharmacy
Zengying Liu, Chen Guan, Chenyu Li, Ningxin Zhang, Chengyu Yang, Lingyu Xu, Bin Zhou, Long Zhao, Hong Luan, Xiaofei Man, Yan Xu
Summary: This study found that tilianin has a protective effect on I/R-induced AKI through the ERK/EGR1/BCL2L1 pathway by using bioinformatics analysis. It provides new insights into the protective effect and underlying molecular mechanisms of tilianin on I/R-induced AKI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qian Chen, Fei Ding, Shuangye Zhang, Qian Li, Xiaoguo Liu, Haiyun Song, Xiaolei Zuo, Chunhai Fan, Shan Mou, Zhilei Ge
Summary: The development of a renal-accumulating DNA nanodevice in this study offers promising protection for acute kidney injury patients in different stages, with potential for providing durable and pathogenic treatment for kidney dysfunction based on the pathophysiological events caused by ischemia-reperfusion.
Article
Immunology
Zhenhan Li, Nadine Ludwig, Katharina Thomas, Sina Mersmann, Martin Lehmann, Dietmar Vestweber, Jean-Francois Pittet, Hernando Gomez, John A. Kellum, Jan Rossaint, Alexander Zarbock
Summary: This study investigated the role of neutrophils in kidney injury and function in two different murine models of acute kidney injury (AKI). The results showed that neutrophil migration into the kidney is involved in the pathogenesis of AKI induced by renal ischemia-reperfusion injury, while neutrophil recruitment is not related to the pathogenesis of AKI induced by sepsis. Furthermore, circulating inflammatory mediators seem to play a role in sepsis-induced AKI. These findings contribute to our understanding of the pathogenesis of AKI and may have implications for the development of preventive and therapeutic treatments for AKI patients.
FRONTIERS IN IMMUNOLOGY
(2022)