YB-1: oncoprotein, prognostic marker and therapeutic target?

Gene Silencing by Gold Nanoshell-Mediated Delivery and Laser-Triggered Release of Antisense Oligonucleotide and siRNA

(2012) Ryan Huschka et al.   ACS Nano

Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

(2012) Edita Aksamitiene et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Association of Nuclear YB-1 Localization With Lung Resistance-related Protein and Epidermal Growth Factor Receptor Expression in Lung Cancer

(2012) Akira Hyogotani et al.   Clinical Lung Cancer

MAPK and PI3K/AKT mediated YB-1 activation promotes melanoma cell proliferation which is counteracted by an autoregulatory loop

(2012) Tobias Sinnberg et al.   EXPERIMENTAL DERMATOLOGY

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches

(2012) Antonella De Luca et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition

(2012) A Astanehe et al.   ONCOGENE

Regulation and function of the RSK family of protein kinases

(2011) Yves Romeo et al.   BIOCHEMICAL JOURNAL

YB-1 Bridges Neural Stem Cells and Brain Tumor-Initiating Cells via Its Roles in Differentiation and Cell Growth

(2011) A. Fotovati et al.   CANCER RESEARCH

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Fas death receptor signalling: roles of Bid and XIAP

(2011) T Kaufmann et al.   CELL DEATH AND DIFFERENTIATION

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

Newly identified aspects of tumor suppression by RB

(2011) P. Viatour et al.   Disease Models & Mechanisms

Role of cold shock Y-box protein-1 in inflammation, atherosclerosis and organ transplant rejection

(2011) Ute Raffetseder et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cold shock Y-box protein-1 participates in signaling circuits with auto-regulatory activities

(2011) Sabine Brandt et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma

(2011) Huiling Shen et al.   EXPERIMENTAL HEMATOLOGY

p53 suppresses lung resistance-related protein expression through Y-box binding protein 1 in the MCF-7 breast tumor cell line

(2011) Baolei Tian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metabolic regulation by p53

(2011) Oliver D. K. Maddocks et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

YB-1, the E2F Pathway, and Regulation of Tumor Cell Growth

(2011) Annette Lasham et al.   JNCI-Journal of the National Cancer Institute

DNA Damage Signals through Differentially Modified E2F1 Molecules To Induce Apoptosis

(2011) J. Carnevale et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

E2F transcription factor-1 regulates oxidative metabolism

(2011) Emilie Blanchet et al.   NATURE CELL BIOLOGY

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification

(2011) A H Davies et al.   ONCOGENE

Prognostic Association of YB-1 Expression in Breast Cancers: A Matter of Antibody

(2011) Adele G. Woolley et al.   PLoS One

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pRB, a tumor suppressor with a stabilizing presence

(2011) Amity L. Manning et al.   TRENDS IN CELL BIOLOGY

YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis

(2010) David H. Lovett et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Twist1 and Y-box-binding protein-1 promote malignant potential in bladder cancer cells

(2010) Masaki Shiota et al.   BJU INTERNATIONAL

Y-Box Binding Protein-1 Induces the Expression ofCD44andCD49fLeading to Enhanced Self-Renewal, Mammosphere Growth, and Drug Resistance

(2010) Karen To et al.   CANCER RESEARCH

Vessel abnormalization: another hallmark of cancer?Molecular mechanisms and therapeutic implications

(2010) Katrien De Bock et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Translating DNA damage into cancer cell death—A roadmap for E2F1 apoptotic signalling and opportunities for new drug combinations to overcome chemoresistance

(2010) David Engelmann et al.   DRUG RESISTANCE UPDATES

Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells

(2010) Yuji Basaki et al.   EUROPEAN JOURNAL OF CANCER

The promise and challenges of targeting RSK for the treatment of cancer

(2010) Anna L Stratford et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Targeting RSK2 in human malignancies

(2010) Sumin Kang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

(2010) Audrey Carriere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pathophysiology of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor-β in Normal and Malignant Mammary Epithelial Cells

(2010) Molly A. Taylor et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The expression of activated Y-box binding protein-1 serine 102 mediates trastuzumab resistance in breast cancer cells by increasing CD44+ cells

(2010) J Dhillon et al.   ONCOGENE

DUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small-cell lung cancer

(2010) V Moncho-Amor et al.   ONCOGENE

Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1

(2010) J Kalra et al.   ONCOGENE

Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1

(2010) L C Cobbold et al.   ONCOGENE

Identification of Y-Box Binding Protein 1 As a Core Regulator of MEK/ERK Pathway-Dependent Gene Signatures in Colorectal Cancer Cells

(2010) Karsten Jürchott et al.   PLoS Genetics

Molecular interactions in cancer cell metastasis

(2009) Susan A. Brooks et al.   ACTA HISTOCHEMICA

Nuclear detection of Y-boxprotein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer

(2009) Edgar Dahl et al.   BMC CANCER

Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition

(2009) Valentina Evdokimova et al.   CANCER CELL

Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways

(2009) A. J. Schetter et al.   CARCINOGENESIS

YB-1 Acts as a Ligand for Notch-3 Receptors and Modulates Receptor Activation

(2009) Thomas Rauen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase

(2009) Y. Gao et al.   MOLECULAR CANCER THERAPEUTICS

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing

(2009) S B Cohen et al.   ONCOGENE

The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1

(2009) A Astanehe et al.   ONCOGENE

Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells

(2009) M R Finkbeiner et al.   ONCOGENE

The angiogenic switch in carcinogenesis

(2009) Vanessa Baeriswyl et al.   SEMINARS IN CANCER BIOLOGY

Caspase activation cascades in apoptosis

(2008) Susan E. Logue et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

An E2F1-Dependent Gene Expression Program that Determines the Balance between Proliferation and Cell Death

(2008) Timothy C. Hallstrom et al.   CANCER CELL

The inflammatory chemokines CCL2 and CCL5 in breast cancer

(2008) Gali Soria et al.   CANCER LETTERS

Targeting YB-1 in HER-2 Overexpressing Breast Cancer Cells Induces Apoptosis via the mTOR/STAT3 Pathway and Suppresses Tumor Growth in Mice

(2008) Cathy Lee et al.   CANCER RESEARCH

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

(2008) T. T. Onder et al.   CANCER RESEARCH

Expression of membrane type 1 matrix metalloproteinase (MMP-14) in epithelial ovarian cancer: High level expression in clear cell carcinoma

(2008) Brian P. Adley et al.   GYNECOLOGIC ONCOLOGY

Isolation and Characterization of a Novel H1.2 Complex That Acts as a Repressor of p53-mediated Transcription

(2008) Kyunghwan Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory Role of Human AP-Endonuclease (APE1/Ref-1) in YB-1-Mediated Activation of the Multidrug Resistance Gene MDR1

(2008) R. Chattopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

(2008) A Jeanes et al.   ONCOGENE

CD44v4 Is a Major E-Selectin Ligand that Mediates Breast Cancer Cell Transendothelial Migration

(2008) Ke Zen et al.   PLoS One

The Y-box binding protein YB-1 is associated with progressive disease and mediates survival and drug resistance in multiple myeloma

(2007) M. Chatterjee et al.   BLOOD

Y-box protein-1 controls transforming growth factor-β1 translation in proximal tubular cells

(2007) D.J. Fraser et al.   KIDNEY INTERNATIONAL