Hepatocyte growth factor activator inhibitor type 2 (HAI-2) modulates hepcidin expression by inhibiting the cell surface protease matriptase-2
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Title
Hepatocyte growth factor activator inhibitor type 2 (HAI-2) modulates hepcidin expression by inhibiting the cell surface protease matriptase-2
Authors
Keywords
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Journal
BIOCHEMICAL JOURNAL
Volume 450, Issue 3, Pages 583-593
Publisher
Portland Press Ltd.
Online
2013-01-10
DOI
10.1042/bj20121518
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Related references
Note: Only part of the references are listed.- Hepatocyte Growth Factor Activation Inhibitors – Therapeutic Potential in Cancer
- (2012) Christian Parr et al. Anti-Cancer Agents in Medicinal Chemistry
- Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region
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- Regulation of TMPRSS6 by BMP6 and iron in human cells and mice
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- Essential Role of Endocytosis of the Type II Transmembrane Serine Protease TMPRSS6 in Regulating Its Functionality
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- Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface
- (2010) Marit Stirnberg et al. BIOCHEMICAL JOURNAL
- Mechanisms of Macromolecular Protease Inhibitors
- (2010) Christopher J. Farady et al. CHEMBIOCHEM
- Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors
- (2010) Samira Lakhal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Matriptase-2- and Proprotein Convertase-cleaved Forms of Hemojuvelin Have Different Roles in the Down-regulation of Hepcidin Expression
- (2010) Julia E. Maxson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transport via the Transcytotic Pathway Makes Prostasin Available as a Substrate for Matriptase
- (2010) Stine Friis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of the First Low-Molecular-Weight Inhibitors of Matriptase-2
- (2010) Mihiret Tekeste Sisay et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mutations in SPINT2 Cause a Syndromic Form of Congenital Sodium Diarrhea
- (2009) Peter Heinz-Erian et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition
- (2009) Jehng-Kang Wang et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Requirement of the activity of hepatocyte growth factor activator inhibitor type 1 for the extracellular appearance of a transmembrane serine protease matriptase in monkey kidney COS-1 cells
- (2009) Yuka Miyake et al. CYTOTECHNOLOGY
- Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1
- (2008) I-Chu Tseng et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis
- (2008) A. R. Folgueras et al. BLOOD
- The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin
- (2008) Laura Silvestri et al. Cell Metabolism
- Potent Inhibition and Global Co-localization Implicate the Transmembrane Kunitz-type Serine Protease Inhibitor Hepatocyte Growth Factor Activator Inhibitor-2 in the Regulation of Epithelial Matriptase Activity
- (2008) Roman Szabo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
- (2008) Karin E Finberg et al. NATURE GENETICS
- The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
- (2008) X. Du et al. SCIENCE
- Zymogen activation, inhibition, and ectodomain shedding of matriptase
- (2007) Chen-Yong Lin Frontiers in Bioscience-Landmark
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