Article
Biochemistry & Molecular Biology
Qinqin Xu, Xiaoling Zhang, Tao Li, Shiying Shao
Summary: This study found that exenatide can restore the Th17/Treg balance in obese diabetic mice by regulating the FoxO1 pathway, thereby improving the progression of diabetes and protecting pancreatic beta-cell function.
MOLECULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Usman Sabir, Hafiz Muhammad Irfan, Alamgeer, Ihtisham Umer, Zahid Rasul Niazi, Hafiz Muhammad Mazhar Asjad
Summary: Literature evidence suggests that natural compounds have the potential to improve obesity-associated non-alcoholic fatty liver disease (NAFLD) by targeting the forkhead box O1 (FOXO1) transcription factor. Certain phytochemicals, such as polyphenols, flavonoids, alkaloids, terpenoids, and anthocyanins, can modulate FOXO1 and its associated signaling pathways, making them potential therapeutic agents for NAFLD and related complications.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Xiaojun Zhang, Lusheng Jiang, Huimin Liu
Summary: Forkhead box protein O1 (FoXO1) is a transcription factor involved in regulating various physiological processes, with dysfunction linked to the pathophysiology of multiple diseases. Different post-translational modifications can dynamically regulate FoXO1 activity and target gene transcription.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Weiguo Wang, Xinjie Jiang, Fei Xia, Xudong Chen, Guojun Li, Lizhuan Liu, Qiang Xu, Min Zhu, Cheng Chen
Summary: The study found that HYOU1 is highly expressed in BCa tissues and cells, and is associated with histological grade and pathologic stage of bladder cancer. HYOU1 promotes cell proliferation, migration, and invasion, while inhibiting apoptosis, thus playing a crucial role in BCa progression. Furthermore, the study revealed the involvement of the HYOU1/PI3K-AKT/FOXO1 negative feedback loop in BCa cell functions.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Fei Li, Weiwei Xie, Yunze Fang, Kunfeng Xie, Wendong Liu, Lina Hou, Wanlong Tan
Summary: HnRNP-F promotes the proliferation of BC cells through the PI3K/AKT pathway and is regulated by phosphorylation of FOXO1.
Article
Dentistry, Oral Surgery & Medicine
Hui Deng, Yixuan Gong, Yuan Chen, Guigui Zhang, Hui Chen, Tianfan Cheng, Lijian Jin, Yi Wang
Summary: Porphyromonas gingivalis lipopolysaccharide affects the angiogenic capacity of endothelial progenitor cells (EPCs) through the Akt/FoxO1 signaling pathway. This finding may provide insights into the clinical association between periodontitis and aberrant angiogenesis in atherosclerotic plaque rupture.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chao Chen, Yu'e Liu, Hongxiang Wang, Xu Zhang, Yufeng Shi, Juxiang Chen
Summary: We investigated the role of FOXO1 and miR-506 in the progression and drug resistance of GBM. Through in vitro and in vivo experiments, we found that the FOXO1-miR-506 axis suppresses GBM cell invasion and migration and promotes chemosensitivity to TMZ, mediated by autophagy. We also discovered a negative feedback loop of FOXO1/miR-506/ETS1/FOXO1 in regulating invasiveness and chemosensitivity in GBM.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Cell Biology
Yixuan Jiang, Wenqiong Luo, Feng Zhou, Ping Gong, Yi Xiong
Summary: This study found that FOXO1 plays an important regulatory role in bone formation, and autophagy may be one of its underlying mechanisms.
Review
Pharmacology & Pharmacy
Yan Wang, Weichun He
Summary: A significant proportion of diabetes patients will develop kidney disease, with Diabetic Kidney Disease (DKD) being a major complication and leading cause of end-stage kidney disease worldwide. FoxO1 transcription factor plays a crucial role in the pathogenesis of DKD and may be a potential clinical target for prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kate L. Weeks, Yow Keat Tham, Suzan G. Yildiz, Yonali Alexander, Daniel G. Donner, Helen Kiriazis, Claudia A. Harmawan, Amy Hsu, Bianca C. Bernardo, Aya Matsumoto, Ronald A. DePinho, E. Dale Abel, Elizabeth A. Woodcock, Julie R. McMullen
Summary: This study found that the transcription factor FoxO1 is a critical mediator of exercise-induced cardiac hypertrophy, which has important implications when considering FoxO1 as a target for treating the diseased heart. Given that exercise-induced hypertrophy is protective, this finding is significant in the context of treating heart disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ioannis D. Kyriazis, Matthew Hoffman, Lea Gaignebet, Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D. Bannister, Melpo Christofidou-Solomidou, Shin-Ichi Oka, Junichi Sadoshima, Walter J. Koch, Ira J. Goldberg, Vincent W. Yang, Agnieszka B. Bialkowska, Georgios Kararigas, Konstantinos Drosatos
Summary: The study revealed that diabetic cardiomyopathy (DbCM) is associated with increased cardiac expression of KLF5, which is regulated by FOXO1. KLF5 induces DbCM by promoting oxidative stress through NOX4 and ceramide accumulation in the heart. Inhibiting KLF5 could alleviate superoxide formation and improve cardiac function in diabetic mice.
CIRCULATION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Liangfeng Jiang, Pinger Li, Shengjun Chen
Summary: AT-I enhances cisplatin sensitivity in renal cell carcinoma cells through activation of the FOXO1-ATG5 pathway-mediated excessive autophagy.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Orthopedics
I. Kurakazu, Y. Akasaki, H. Tsushima, T. Sueishi, M. Toya, M. Kuwahara, T. Uchida, M. K. Lotz, Y. Nakashima
Summary: FOXO1, a key regulator of autophagy, is promoted by TGF-β1 to protect chondrocytes against oxidative stress. Reduced ALK5 expression with aging may lead to decreased FOXO1 expression.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Medicine, Research & Experimental
Tao Geng, Zesheng Xu, Jingxian Xing, Yonggang Yuan, Juan Liu
Summary: Accumulating evidence suggests that lncRNA SNHG16 plays a role in myocardial ischemia/reperfusion (I/R) injury. Inhibition of SNHG16 alleviates cardiomyocyte apoptosis induced by hypoxia/reoxygenation (H/R) and myocardial I/R injury. SNHG16 interacts with miR-183, which targets forkhead box O1 (FoxO1). The SNHG16/miR-183/FOXO1 axis exacerbates myocardial cell apoptosis in myocardial I/R injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Endocrinology & Metabolism
Xiaoou Li, Jie Jin, Xuefeng Long, Ruiwen Weng, Wenqian Xiong, Jiaxin Liang, Junjun Liu, Jingwen Sun, Xueqin Cai, Ling Zhang, Yi Liu
Summary: The study found that the expression of m6A and METTL3 varied in different groups of women, including normal fertile women and those with endometriosis-related infertility. The research suggests that METTL3-regulated m6A plays a role in affecting cellular decidualization and embryo implantation.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)