Loss of the Polarity Protein PAR3 Activates STAT3 Signaling via an Atypical Protein Kinase C (aPKC)/NF-κB/Interleukin-6 (IL-6) Axis in Mouse Mammary Cells

Host Cell Polarity Proteins Participate in Innate Immunity to Pseudomonas aeruginosa Infection

(2014) Cindy S. Tran et al.   Cell Host & Microbe

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNF  in glioblastoma

(2014) Y. Kusne et al.   Science Signaling

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

(2014) Koji Taniguchi et al.   SEMINARS IN IMMUNOLOGY

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids

(2013) Mark Linch et al.   CARCINOGENESIS

Prkcz null mice show normal learning and memory

(2013) Anna M. Lee et al.   NATURE

PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory

(2013) Lenora J. Volk et al.   NATURE

LKB1 Inhibits Breast Cancer Partially through Repressing the Hedgehog Signaling Pathway

(2013) Zhigang Zhuang et al.   PLoS One

Par-complex aPKC and Par3 cross-talk with innate immunity NF- B pathway in epithelial cells

(2013) R. Forteza et al.   Biology Open

Tumor Type-Dependent Function of the Par3 Polarity Protein in Skin Tumorigenesis

(2012) Sandra Iden et al.   CANCER CELL

Loss of the Par3 Polarity Protein Promotes Breast Tumorigenesis and Metastasis

(2012) Luke Martin McCaffrey et al.   CANCER CELL

Interleukin-6 signaling pathway in targeted therapy for cancer

(2012) Yuqi Guo et al.   CANCER TREATMENT REVIEWS

Loss of Par3 promotes breast cancer metastasis by compromising cell–cell cohesion

(2012) Bin Xue et al.   NATURE CELL BIOLOGY

Hugl1 and Hugl2 in Mammary Epithelial Cells: Polarity, Proliferation, and Differentiation

(2012) Atlantis Russ et al.   PLoS One

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

(2011) Manav Korpal et al.   NATURE MEDICINE

Loss of the 14-3-3σ Tumor Suppressor Is a Critical Event in ErbB2-Mediated Tumor Progression

(2011) Chen Ling et al.   Cancer Discovery

A Genome-Wide Screen for Microdeletions Reveals Disruption of Polarity Complex Genes in Diverse Human Cancers

(2010) S. M. Rothenberg et al.   CANCER RESEARCH

Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten

(2010) I. Barbieri et al.   CANCER RESEARCH

Par3 Controls Epithelial Spindle Orientation by aPKC-Mediated Phosphorylation of Apical Pins

(2010) Yi Hao et al.   CURRENT BIOLOGY

Oncogenic Ras Diverts a Host TNF Tumor Suppressor Activity into Tumor Promoter

(2010) Julia B. Cordero et al.   DEVELOPMENTAL CELL

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

(2010) S. Benhamouche et al.   GENES & DEVELOPMENT

Protein Kinase C Isoforms ζ and ι Mediate Collagenase Expression and Cartilage Destruction via STAT3- and ERK-dependent c-fosInduction

(2010) Gary J. Litherland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between Ras V12 and scribbled clones induces tumour growth and invasion

(2010) Ming Wu et al.   NATURE

High Expression of Atypical Protein Kinase C λ/ι in Gastric Cancer as a Prognostic Factor for Recurrence

(2009) Ryo Takagawa et al.   ANNALS OF SURGICAL ONCOLOGY

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

(2009) Gregory R Leong et al.   BMC BIOLOGY

The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis

(2009) L. M. McCaffrey et al.   GENES & DEVELOPMENT

Ikappa B kinaseβ/nuclear factor-κB activation controls the development of liver metastasis by way of interleukin-6 expression

(2009) Shin Maeda et al.   HEPATOLOGY

Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma

(2009) K Zen et al.   ONCOGENE

aPKC /  promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6

(2009) H. Ishiguro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atypical protein kinase C phosphorylates IKKαβ in transformed non-malignant and malignant prostate cell survival

(2008) Hla Y. Win et al.   CANCER LETTERS

The Polarity Protein Par6 Induces Cell Proliferation and Is Overexpressed in Breast Cancer

(2008) M. E. Nolan et al.   CANCER RESEARCH

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

(2008) Lixing Zhan et al.   CELL

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

(2008) Toula Bouras et al.   Cell Stem Cell

Protein Kinase C  Represses the Interleukin-6 Promoter and Impairs Tumorigenesis In Vivo

(2008) A. S. Galvez et al.   MOLECULAR AND CELLULAR BIOLOGY