Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNF  in glioblastoma

PKC signaling in glioblastoma

(2013) Anália do Carmo et al.   CANCER BIOLOGY & THERAPY

EGFR Phosphorylates Tumor-Derived EGFRvIII Driving STAT3/5 and Progression in Glioblastoma

(2013) Qi-Wen Fan et al.   CANCER CELL

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Competing molecular interactions of aPKC isoforms regulate neuronal polarity

(2013) S. S. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

Unknown

(2012) Salvatore Coniglio et al.   MOLECULAR MEDICINE

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

(2011) S. I. Grivennikov et al.   ANNALS OF THE RHEUMATIC DISEASES

Immune microenvironments in solid tumors: new targets for therapy

(2011) S. L. Shiao et al.   GENES & DEVELOPMENT

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR

(2011) Trever G. Bivona et al.   NATURE

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme

(2011) H J Jun et al.   ONCOGENE

Cancer-related inflammation: Common themes and therapeutic opportunities

(2011) Frances R. Balkwill et al.   SEMINARS IN CANCER BIOLOGY

Understanding Glioblastoma Tumor Biology: The Potential to Improve Current Diagnosis and Treatments

(2011) Santosh Kesari   SEMINARS IN ONCOLOGY

Recurrent Glioblastoma: A Fresh Look at Current Therapies and Emerging Novel Approaches

(2011) Mark R. Gilbert   SEMINARS IN ONCOLOGY

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

NF-κB and STAT3 signaling in glioma: targets for future therapies

(2010) George P Atkinson et al.   Expert Review of Neurotherapeutics

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Microglia/macrophages promote glioma progression

(2010) Haiyan Zhai et al.   GLIA

NFKBIADeletion in Glioblastomas

(2010) Markus Bredel et al.   NEW ENGLAND JOURNAL OF MEDICINE

NF-κB addiction and its role in cancer: ‘one size does not fit all’

(2010) M M Chaturvedi et al.   ONCOGENE

Oncogenic Activation of NF- B

(2010) L. M. Staudt   Cold Spring Harbor Perspectives in Biology

Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex

(2009) J Moscat et al.   CELL DEATH AND DIFFERENTIATION

Inflammation and oncogenesis: a vicious connection

(2009) Sergei I Grivennikov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice

(2009) Leying Zhang et al.   GLIA

Atypical protein kinase C activity is required for extracellular matrix degradation and invasion by Src-transformed cells

(2009) Elena M. Rodriguez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Flow cytometry and in vitro analysis of human glioma–associated macrophages

(2009) Ian F. Parney et al.   JOURNAL OF NEUROSURGERY

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

(2009) D. S. Markovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-ζ inhibitor

(2008) John I. Trujillo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NF-κB and cancer—identifying targets and mechanisms

(2008) Willscott E Naugler et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE