Secreted Frizzled-related Protein 5 Diminishes Cardiac Inflammation and Protects the Heart from Ischemia/Reperfusion Injury

Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet

(2016) Rea P. Anunciado-Koza et al.   BIOCHIMIE

Mest and Sfrp5 are biomarkers for healthy adipose tissue

(2016) Magdalena Jura et al.   BIOCHIMIE

Cell-cell interaction in the heart via Wnt/ -catenin pathway after cardiac injury

(2014) A. Deb   CARDIOVASCULAR RESEARCH

Noncanonical Wnt Signaling Promotes Obesity-Induced Adipose Tissue Inflammation and Metabolic Dysfunction Independent of Adipose Tissue Expansion

(2014) José J. Fuster et al.   DIABETES

Anti-inflammatory therapies for cardiovascular disease

(2014) P. M. Ridker et al.   EUROPEAN HEART JOURNAL

Dapper-1 is essential for Wnt5a induced cardiomyocyte hypertrophy by regulating the Wnt/PCP pathway

(2014) Marco Hagenmueller et al.   FEBS LETTERS

Wnt5a-Rac1-NF- B Homeostatic Circuitry Sustains Innate Immune Functions in Macrophages

(2014) D. Naskar et al.   JOURNAL OF IMMUNOLOGY

SFRP5 acts as a mature adipocyte marker but not as a regulator in adipogenesis

(2014) Rui Wang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease

(2014) Ryosuke Kikuchi et al.   NATURE MEDICINE

Balanced duo of anti-inflammatory SFRP5 and proinflammatory WNT5A in children

(2014) Anna Prats-Puig et al.   PEDIATRIC RESEARCH

Identification of Adipokine Clusters Related to Parameters of Fat Mass, Insulin Sensitivity and Inflammation

(2014) Gesine Flehmig et al.   PLoS One

C1q/Tumor Necrosis Factor-Related Protein-9, a Novel Adipocyte-Derived Cytokine, Attenuates Adverse Remodeling in the Ischemic Mouse Heart via Protein Kinase A Activation

(2013) Y. Sun et al.   CIRCULATION

Adipokines: A link between obesity and cardiovascular disease

(2013) Kazuto Nakamura et al.   Journal of Cardiology

Immune Cell Modulation of Cardiac Remodeling

(2012) Richard M. Mortensen   CIRCULATION

Cardiovascular and Metabolic Regulation by the Adiponectin/C1q/Tumor Necrosis Factor–Related Protein Family of Proteins

(2012) Noriyuki Ouchi et al.   CIRCULATION

Regulation of the Inflammatory Response in Cardiac Repair

(2012) Nikolaos G. Frangogiannis   CIRCULATION RESEARCH

Wnt5a activates THP-1 monocytic cells via a β-catenin-independent pathway involving JNK and NF-κB activation

(2012) Jungtae Kim et al.   CYTOKINE

CTRP9 Protein Protects against Myocardial Injury following Ischemia-Reperfusion through AMP-activated Protein Kinase (AMPK)-dependent Mechanism

(2012) Takahiro Kambara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating Sfrp5 Is a Signature of Obesity-Related Metabolic Disorders and Is Regulated by Glucose and Liraglutide in Humans

(2012) Wenjing Hu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential

(2012) Kristin Dawson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pro-Inflammatory wnt5a and Anti-Inflammatory sFRP5 Are Differentially Regulated by Nutritional Factors in Obese Human Subjects

(2012) Dominik M. Schulte et al.   PLoS One

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Alternative Wnt Pathways and Receptors

(2012) R. van Amerongen   Cold Spring Harbor Perspectives in Biology

The Wnt/Frizzled pathway as a therapeutic target for cardiac hypertrophy: where do we stand?

(2011) P. ter Horst et al.   Acta Physiologica

Secreted Frizzled-Related Protein-1 Improves Postinfarction Scar Formation Through a Modulation of Inflammatory Response

(2011) Laurent Barandon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blocking of Frizzled Signaling With a Homologous Peptide Fragment of Wnt3a/Wnt5a Reduces Infarct Expansion and Prevents the Development of Heart Failure After Myocardial Infarction

(2011) Hilde Laeremans et al.   CIRCULATION

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production

(2011) Martina Rauner et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Monocytes: Protagonists of Infarct Inflammation and Repair After Myocardial Infarction

(2010) Matthias Nahrendorf et al.   CIRCULATION

The Multiple Phases and Faces of Wnt Signaling During Cardiac Differentiation and Development

(2010) Susanne Gessert et al.   CIRCULATION RESEARCH

An Updated Overview on Wnt Signaling Pathways

(2010) Tata Purushothama Rao et al.   CIRCULATION RESEARCH

WNT Signaling in Adult Cardiac Hypertrophy and Remodeling

(2010) Martin W. Bergmann   CIRCULATION RESEARCH

Wnt Signaling Is Critical for Maladaptive Cardiac Hypertrophy and Accelerates Myocardial Remodeling

(2010) Pratima Malekar et al.   HYPERTENSION

sFRP2 Suppression of Bone Morphogenic Protein (BMP) and Wnt Signaling Mediates Mesenchymal Stem Cell (MSC) Self-renewal Promoting Engraftment and Myocardial Repair

(2010) Maria P. Alfaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction

(2010) W. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity

(2010) N. Ouchi et al.   SCIENCE

The Wnt pathway: A macrophage effector molecule that triggers inflammation

(2009) Claudia P. Pereira et al.   Current Atherosclerosis Reports

Wnt5A/CaMKII Signaling Contributes to the Inflammatory Response of Macrophages and Is a Target for the Antiinflammatory Action of Activated Protein C and Interleukin-10

(2008) Claudia Pereira et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin

(2008) G. William Wong et al.   FASEB JOURNAL

Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling

(2008) Y. Li et al.   GENES & DEVELOPMENT

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/β-catenin and the planar cell polarity pathways during early trunk formation in mouse

(2008) Wataru Satoh et al.   GENESIS

Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

(2008) P. Bovolenta et al.   JOURNAL OF CELL SCIENCE