Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics

(2015) Angela Schoch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conserved P-loop anchor limits the structural dynamics that mediate nucleotide dissociation in EF-Tu

(2015) Evan Mercier et al.   Scientific Reports

Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions

(2015) Céline Monnet et al.   Frontiers in Immunology

pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling

(2014) M. Jack Borrok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

(2014) Vaheh Oganesyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life

(2014) Ranajoy Majumdar et al.   mAbs

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

(2014) Bing Li et al.   mAbs

Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry

(2014) Pernille Foged Jensen et al.   MOLECULAR & CELLULAR PROTEOMICS

Conformational dynamics in substrate-binding domains influences transport in the ABC importer GlnPQ

(2014) Giorgos Gouridis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein conformational dynamics dictate the binding affinity for a ligand

(2014) Moon-Hyeong Seo et al.   Nature Communications

Molecular origins of binding affinity: seeking the Archimedean point

(2013) Panagiotis L Kastritis et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

(2013) Tilman Schlothauer et al.   mAbs

Folding of a large protein at high structural resolution

(2013) B. T. Walters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry

(2013) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minimizing Back Exchange in the Hydrogen Exchange-Mass Spectrometry Experiment

(2012) Benjamin T. Walters et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Protein activity regulation by conformational entropy

(2012) Shiou-Ru Tzeng et al.   NATURE

Evidence for dynamics in proteins as a mechanism for ligand dissociation

(2012) Mary J Carroll et al.   Nature Chemical Biology

Protein hydrogen exchange: Testing current models

(2012) John J. Skinner et al.   PROTEIN SCIENCE

Protein dynamics viewed by hydrogen exchange

(2012) John J. Skinner et al.   PROTEIN SCIENCE

Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

(2011) W. Wang et al.   DRUG METABOLISM AND DISPOSITION

ExMS: Data Analysis for HX-MS Experiments

(2011) Zhong-Yuan Kan et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Many Overlapping Peptides for Protein Hydrogen Exchange Experiments by the Fragment Separation-Mass Spectrometry Method

(2011) Leland Mayne et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Expansion of time window for mass spectrometric measurement of amide hydrogen/deuterium exchange reactions

(2010) Stephen J. Coales et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Structural characterization of a human Fc fragment engineered for extended serum half-life

(2009) Vaheh Oganesyan et al.   MOLECULAR IMMUNOLOGY

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology