Evidence for dynamics in proteins as a mechanism for ligand dissociation

Direct Detection of Structurally Resolved Dynamics in a Multiconformation Receptor−Ligand Complex

(2011) Mary J. Carroll et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Drug–target residence time: critical information for lead optimization

(2010) Hao Lu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Multi-Timescale Dynamics Study of FKBP12 Along the Rapamycin–mTOR Binding Coordinate

(2010) Paul J. Sapienza et al.   JOURNAL OF MOLECULAR BIOLOGY

Toward Flexibility−Activity Relationships by NMR Spectroscopy: Dynamics of Pin1 Ligands

(2010) Andrew T. Namanja et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamics connect substrate recognition to catalysis in protein kinase A

(2010) Larry R Masterson et al.   Nature Chemical Biology

Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands

(2010) D. D. Boehr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Dysfunction in Dihydrofolate Reductase Results from Antifolate Drug Binding: Modulation of Dynamics within a Structural State

(2009) Randall V. Mauldin et al.   STRUCTURE

Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

(2008) Peter J. Tummino et al.   BIOCHEMISTRY

Using relaxation dispersion NMR spectroscopy to determine structures of excited, invisible protein states

(2008) D. Flemming Hansen et al.   JOURNAL OF BIOMOLECULAR NMR

Probing Chemical Shifts of Invisible States of Proteins with Relaxation Dispersion NMR Spectroscopy: How Well Can We Do?

(2008) D. Flemming Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes

(2003) Michael J. Osborne et al.   PROTEIN SCIENCE