Article
Biochemistry & Molecular Biology
Xu Cheng, Yixuan Huang, Yingmeng Liu, Jinfeng Dou, Ning Zhao, Jingtao Li, Bing Shi
Summary: Branchiomeric head muscle and somitic limb muscle present distinct regenerative characteristics, with the fibrosis mechanism in head muscle still elusive. FAPs play a persistent role in head muscle regeneration, possibly contributing to fibrosis due to their prolonged presence in the early regeneration stages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Lutian Yao, Elisia D. Tichy, Leilei Zhong, Sarthak Mohanty, Luqiang Wang, Emily Ai, Shuying Yang, Foteini Mourkioti, Ling Qin
Summary: Gli1+ FAPs play a crucial role in skeletal muscle repair by relying on Hh signaling to promote the growth of regenerating myofibers. These cells demonstrate superior clonogenicity and reduced adipogenic differentiation ability, enhancing myogenesis and reducing adipogenesis after injury.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Biology
Gillian Fitzgerald, Guillermo Turiel, Tatiane Gorski, Ines Soro-Arnaiz, Jing Zhang, Nicola C. Casartelli, Evi Masschelein, Nicola A. Maffiuletti, Reto Sutter, Michael Leunig, Jean Farup, Katrien De Bock
Summary: In this study, the heterogeneity of FAP cells in patients with fatty infiltration was characterized using single-nuclei and single-cell RNA sequencing. An MME+ FAP subpopulation with high adipogenic potential was identified, which showed resistance to WNT activators. It was also found that many MME+ FAP cells undergo apoptosis during muscle regeneration and differentiate into adipocytes under pathological conditions.
COMMUNICATIONS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Giulio Giuliani, Marco Rosina, Alessio Reggio
Summary: Fibro/adipogenic progenitor cells (FAPs) play a critical role in modulating muscle regeneration, supporting MuSCs in maintaining tissue homeostasis, but disruption of niche cues can lead to their differentiation into harmful adipocytes and fibroblasts. Efforts are focused on understanding the molecular circuits governing their behavior and utilizing single-cell technologies to study FAP transitional states in muscle regeneration and myopathies.
Article
Multidisciplinary Sciences
Cansu Ozdemir, Duygu Akcay, Digdem Yoyen-Ermis, Ekim Zihni Taskiran, Rana Soylu-Kucharz, Guenes Esendagli, Yusuf Cetin Kocaefe
Summary: Chronic skeletal muscle degeneration is characterized by fiber atrophy accompanied by deposition of extracellular matrix (ECM) components and fatty infiltration. Excessive accumulation of ECM leads to fibrosis via the contribution of fibro-adipogenic precursors (FAPs). Fibrosis also accompanies disuse atrophy and sarcopenia without significant inflammation.
Review
Cell Biology
Taryn Loomis, Lucas R. Smith
Summary: This review summarizes the role of fibro-adipogenic progenitors (FAPs) in muscle fibrosis, including their activation, heterogeneity, and contribution to muscle fibrotic degeneration, and discusses current research on potential therapeutic avenues targeting FAPs.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Allah Nawaz, Muhammad Bilal, Shiho Fujisaka, Tomonobu Kado, Muhammad Rahil Aslam, Saeed Ahmed, Keisuke Okabe, Yoshiko Igarashi, Yoshiyuki Watanabe, Takahide Kuwano, Koichi Tsuneyama, Ayumi Nishimura, Yasuhiro Nishida, Seiji Yamamoto, Masakiyo Sasahara, Johji Imura, Hisashi Mori, Martin M. Matzuk, Fujimi Kudo, Ichiro Manabe, Akiyoshi Uezumi, Takashi Nakagawa, Yumiko Oishi, Kazuyuki Tobe
Summary: This study reveals that CD206+ macrophages inhibit the secretion of follistatin by FAPs, impeding muscle regeneration. Activated FAPs secrete follistatin to boost the recovery process.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Huan Li, Jinfu Lin, Liang Wang, Ruojie He, Jing Li, Menglong Chen, Weixi Zhang, Cheng Zhang
Summary: The overexpression of IL4 in ADSC promotes myogenesis and alters the interaction between ADSC and FAPs, leading to improved motor function and molecular improvements in dystrophic mice. Administering IL4-ADSC-derived myoblasts results in better muscle function and reduced muscle fibrosis, adipocyte infiltration, and macrophage infiltration compared to control-ADSC-derived myoblasts.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Taryn Loomis, Lin-Ya Hu, Ross P. Wohlgemuth, Rosemary R. Chellakudam, Lucas R. Smith
Summary: This study demonstrates that fibrotic muscle stiffness can activate FAPs to become myofibroblasts through YAP signaling, driving the progression of muscle fibrosis. However, fibrotic collagen architecture actually inhibits myofibroblast activation through a YAP independent mechanism.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
John B. Lees-Shepard, Sean J. Stoessel, Julian T. Chandler, Keith Bouchard, Patricia Bento, Lorraine N. Apuzzo, Parvathi M. Devarakonda, Jeffrey W. Hunter, David J. Goldhamer
Summary: Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive and catastrophic heterotopic ossification (HO). This study found that a monoclonal blocking antibody, JAB0505, exacerbated injury-induced HO in FOP mouse models, raising concerns about its safety and efficacy for treating FOP patients.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Developmental Biology
Brittany C. Collins, Gabrielle Kardon
Summary: Vertebrate skeletal muscle is composed of multinucleate myofibers surrounded by muscle connective tissue, and can robustly regenerate following injury through satellite cells. Satellite cells and FAPs are heterogeneous cell populations, with current understanding focusing on gene expression, anatomical location, age, and timing during the regenerative process.
Review
Multidisciplinary Sciences
Obiajulu Agha, Agustin Diaz, Michael Davies, Hubert T. Kim, Xuhui Liu, Brian T. Feeley
Summary: The high prevalence of rotator cuff tears presents challenges for patients and the healthcare system. Surgical repair often leads to high retear rates, with outcomes depending on the quality of injured rotator cuff muscles. Exploration of the pathophysiology of rotator cuff degeneration, particularly the role of fibro-adipogenic progenitors, is crucial for potential therapeutics and improved outcomes.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Thomas Molina, Paul Fabre, Nicolas A. Dumont
Summary: Skeletal muscle regeneration relies on the coordination between muscle stem cells and fibro-adipogenic progenitors (FAPs), with FAPs playing a crucial role by supporting myogenic activity and exhibiting cellular heterogeneity.
Article
Biochemistry & Molecular Biology
Felipe S. Gallardo, Adriana Cordova-Casanova, Alexia Bock-Pereda, Daniela L. Rebolledo, Andrea Ravasio, Juan Carlos Casar, Enrique Brandan
Summary: Loss of motoneuron innervation leads to fibrosis in skeletal muscle, which is attributed to the activation and expansion of resident fibro/adipogenic progenitors (FAPs). Our study reveals FAPs as a novel cell population that activates the transcriptional coregulators YAP/TAZ in response to skeletal muscle denervation. Denervation induces YAP expression and transcriptional activity in FAPs, as shown by in vivo and in silico approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Wentao Chen, Wenjing You, Teresa G. Valencak, Tizhong Shan
Summary: This review summarizes the roles of fibro-adipogenic progenitors (FAPs) in maintaining skeletal muscle homeostasis and discusses the underlying mechanisms regulating FAPs behavior and fate. FAPs play supportive roles in coordinating the regulatory interplay between muscle stem cells and immune cells, but can also contribute to muscle pathology when the functional integrity of the network is compromised.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Dario R. Lemos, Farshad Babaeijandaghi, Marcela Low, Chih-Kai Chang, Sunny T. Lee, Daniela Fiore, Regan-Heng Zhang, Anuradha Natarajan, Sergei A. Nedospasov, Fabio M. V. Rossi
Article
Multidisciplinary Sciences
Kyle Peake, John Manning, Coral-Ann Lewis, Christine Barr, Fabio Rossi, Charles Krieger
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2015)
Editorial Material
Neurosciences
Fabio Rossi, Coral Lewis
NATURE NEUROSCIENCE
(2018)
Review
Clinical Neurology
Nathalie Cartier, Coral-Ann Lewis, Regan Zhang, Fabio M. V. Rossi
ACTA NEUROPATHOLOGICA
(2014)
Review
Developmental Biology
Marine Theret, Remi Mounier, Fabio Rossi
Article
Cell Biology
Osvaldo Contreras, Meilyn Cruz-Soca, Marine Theret, Hesham Soliman, Lin Wei Tung, Elena Groppa, Fabio M. Rossi, Enrique Brandan
JOURNAL OF CELL SCIENCE
(2019)
Article
Endocrinology & Metabolism
Christine Eisner, Michael Cummings, Gabrielle Johnston, Lin Wei Tung, Elena Groppa, Chihkai Chang, Fabio M. Rossi
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Cell Biology
Osvaldo Contreras, Hesham Soliman, Marine Theret, Fabio M. Rossi, Enrique Brandan
JOURNAL OF CELL SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Fabio Rossi, Martin Braun, Jonathan Brock, Janette Sen-Lum, Sonya Ellens, Elliot Lander, Douglas Stoddard, Carolyn Cross, Angelika Vance, Duncan Stewart, Bernard Thebaud, Judy Illes
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Cell Biology
Andreas Lindhorst, Nora Raulien, Peter Wieghofer, Jens Eilers, Fabio M. Rossi, Ingo Bechmann, Martin Gericke
Summary: Chronic low-grade inflammation in adipose tissue is linked to obesity and associated diseases, with adipocyte death triggering a unique degradation process that locally induces a metabolically activated ATM phenotype. This pro-inflammatory response in adipose tissue due to adipocyte death occurs even in lean animals under homeostatic conditions, highlighting the role of cell size in the inflammatory response.
CELL DEATH & DISEASE
(2021)
Review
Cell & Tissue Engineering
Hesham Soliman, Marine Theret, Wilder Scott, Lesley Hill, Tully Michael Underhill, Boris Hinz, Fabio M. Rossi
Summary: MSCs are essential for the development, maintenance, function, and regeneration of most tissues. They play a crucial role in responding to injury, promoting regeneration through secretion of trophic factors and ECM molecules, and contributing to fibrotic reparative processes. Through fate mapping and single cell omics, tissue-specific MSC identities and functions are being elucidated, providing unprecedented insights into the secret lives of tissue-resident MSCs.
Article
Oncology
Morten Ritso, Lin Wei Tung, Fabio M. Rossi
Summary: Healthy skeletal muscle relies on both skeletal muscle stem cells and tissue-resident stromal cells for repair and maintenance. Different subpopulations of stromal cells play distinct roles in the regenerative process, and dysregulation of communication among cell populations can lead to pathological changes and decline in muscle function. Restoring proper stromal cell function is crucial for therapeutic targeting and maintaining muscle homeostasis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Zoe White, Marine Theret, Nadia Milad, Lin Wei Tung, William Wei-Han Chen, Martin G. Sirois, Fabio Rossi, Pascal Bernatchez
Summary: Cholesterol exacerbates muscular dystrophy in rodent models, but specific inhibition of cholesterol absorption with ezetimibe can safely attenuate human MD severity and delay death.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biotechnology & Applied Microbiology
Genc Basha, Andrew G. Cottle, Thavaneetharajah Pretheeban, Karen YT. Chan, Dominik Witzigmann, Robert N. Young, Fabio MV. Rossi, Pieter R. Cullis
Summary: The study found that using siRNA to silence the suppressor gene GNAS can enhance the differentiation of osteoblasts and bone formation. The clinically validated LNP-siRNA delivery system can promote MSC differentiation into osteoblasts in animal models.
Article
Cell Biology
Farshad Babaeijandaghi, Ryan Cheng, Nasim Kajabadi, Hesham Soliman, Chih-Kai Chang, Josh Smandych, Lin Wei Tung, Reece Long, Amirhossein Ghassemi, Fabio M. Rossi
Summary: This study identified three populations of skeletal muscle-resident myelomonocytic cells, including macrophages positive for LYVE1 and TIM4, macrophages negative for TIM4, and dendritic cells positive for CD11C and MHCII. Lineage-tracing experiments showed that TIM4(-) macrophages were replenished from the blood, while TIM4(+) macrophages had local self-renewal capacity. The study revealed the unique function of self-renewing resident macrophages in clearing apoptotic cells after extensive acute injury, as well as their role in protecting muscle against injury in a mouse model of muscular dystrophy.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
