Article
Multidisciplinary Sciences
J. S. Park, J. D. Almer, K. C. James, L. J. Natanson, S. R. Stock
Summary: Members of subclass Elasmobranchii possess bioapatite mineralization in their cartilage skeletons, which has similar crystallography to bone but exhibits some differences. The mineral phase in shark centra has larger nanocrystallite sizes and is associated with less microstrain compared to bone.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Cell Biology
Mitsusada Iwasa, Shuichi Takeda, Akihiro Narita, Yuichiro Maeda, Toshiro Oda
Summary: The assembly of actin is regulated by ATP hydrolysis, which leads to conformational changes and rearrangement of water molecules at the active site. Mutations in certain residues affect the polymerization rate and ATP hydrolysis. The crystal structures of mutant actins provide insights into the role of specific residues in ATPase activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Abris Adam Bendes, Petri Kursula, Inari Kursula
Summary: Apicomplexan parasites rely on the glideosome for motility and host cell invasion; actin filament capping proteins (CPs) play a crucial role in regulating actin dynamics; this study presents the crystal structure of CP from the malaria parasite and reveals differences compared to canonical heterodimers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Polymer Science
Apisit Banpean, Hideaki Takagi, Nobutaka Shimizu, Noriyuki Igarashi, Shinichi Sakurai
Summary: The study focused on the confined crystallization of PEG in PLLA spherulite in a PLLA/PEG blend specimen using SAXS/WAXS measurements. The results showed suppression of PEG lamellae growth in the thickness direction due to space confinement by preformed PLLA lamellae, while also observing more regular stacking in the blend specimen.
Review
Chemistry, Analytical
Seema Thakral, Kyungtae Kim
Summary: Small-angle scattering (SAS) is a versatile analytical technique that provides detailed structural information at the nanometer scale. It has diverse applications in pharmaceutical material characterization, including identification of liquid-crystalline mesophase of drugs, study of excipient microstructure influence, and optimization of solid dispersions and protein-based therapeutics formulations.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Physical
Kun Qian, Randall E. Winans, Tao Li
Summary: Understanding the nanostructures of liquid electrolytes is crucial for enhancing electrochemical energy storage capacities, but the solvation structures and molecular dynamics in electrolytes are difficult to probe. Small-angle X-ray scattering (SAXS) offers unique insights into molecular clusters and ion pairs in electrolytes, with excellent time-resolution for studying molecular dynamics. This review focuses on the microscopic understanding of liquid electrolytes by SAXS and highlights the unique capabilities of X-ray scattering for nanostructure characterization.
ADVANCED ENERGY MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Hiroshi Imamura, Shinya Honda
Summary: Antibody aggregation and acid denaturation followed by neutralization of pH contribute to the high cost of therapeutic monoclonal antibody production. Understanding the structural details of acid-denatured antibodies is crucial for antibody engineering. Research has shown that acid-denatured monoclonal antibodies become smaller globules at pH 2 compared to their native structure at pH 7. Small-angle X-ray scattering data indicate conformational changes that can lead to aggregation. The distortion of the Fc region and longer inter-domain correlations are found to initiate acid denaturation and aggregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Enyi Chi, Haiying Huang, Fajun Zhang, Tianbai He
Summary: Crystalline block copolymers have been utilized to create plate-like colloidal systems with controlled size and shape. The structure in solution and the face-to-face spacing were characterized using small- and ultrasmall-angle X-ray scattering techniques, revealing the importance of lateral attraction between polar crystalline blocks for the formation of the nematic phase.
Article
Chemistry, Applied
Thomas Konegger, Christina Drechsel, Herwig Peterlik
Summary: In this study, in-situ small angle X-ray scattering (SAXS) was used to monitor the structural evolution of polymer-derived ceramic materials during the pyrolytic conversion process, focusing on the emergence, transformation, and collapse of transient microporosity. Results showed that the in-situ experiments were in good agreement with conventionally obtained ex-situ data, indicating the significant potential of this method for gaining fundamental insights into the conversion of polymer-derived ceramics.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Polymer Science
Sascha A. Wilhelm, Michail Maricanov, Volker Brandt, Frank Katzenberg, Joerg C. Tiller
Summary: Amphiphilic polymer conetworks (APCNs) combine two incompatible properties within one material by featuring two interconnected independently swelling nanophases. Two novel APCN families have been synthesized using hydrophilic and hydrophobic polymers, respectively, and have demonstrated the ability to swell in orthogonal solvents without changing their nanostructure.
Article
Chemistry, Physical
Qi Han, Kate M. Smith, Connie Darmanin, Timothy M. Ryan, Calum J. Drummond, Tamar L. Greaves
Summary: This study investigates the conformational changes of lysozyme in the presence of ionic liquids using a combination of spectroscopic techniques, small angle X-ray scattering, and X-ray crystallography. The results show that the secondary structure of lysozyme remains stable while the tertiary structure, particularly the loop regions, are sensitive to the concentration and type of ionic liquids.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Medicine, Research & Experimental
Yiwen Li, Jianqiao Zhang, Panqi Song, Xiaran Miao, Guangfeng Liu, Chunming Yang, Xiaohui Wei, Na Li, Fenggang Bian
Summary: This study used SAXS to investigate the structure of PEGylated liposomal doxorubicin (PLD) and compared the suitability of different models. The results showed that spherical-shell and flat-slab models with Gaussian electron density distribution were able to effectively reveal the structural features of the liposomal membrane, while models with uniform electron density distribution performed poorly. This study highlights the applicability of SAXS in liposomal drugs.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Daria Wojciechowska, Michal Taube, Karolina Rucinska, Joanna Maksim, Maciej Kozak
Summary: This study characterized the oligomeric states of human cystatin C in different pH conditions, revealing the ability to form tetramers at low pH and dissociate into dimers at neutral pH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Jana Smilauerova, Petr Harcuba, Jitka Straska, Josef Strasky, Milos Janecek, Jiri Pospisil, Jan Ilavsky, Vaclav Holy
Summary: The shapes and orientations of lamellae in single crystals of metastable beta-Ti alloy were investigated using synchrotron small-angle x-ray scattering. The results provide information on the kinetics of the beta-alpha transformation and the thermodynamic equilibrium of the final alpha-beta composite.
MATERIALS CHARACTERIZATION
(2023)
Article
Chemistry, Physical
Kohei Yamanoi, Satoshi Shibuta, Atsushi Shiro, Masao Noumi, Melvin John F. Empizo, Marilou Cadatal-Raduban, Nobuhiko Sarukura, Keiko Nishikawa, Takeshi Morita
Summary: Fluoropolymers have diverse applications in various industries. Neat fluoropolymers and fluorinated copolymers were synthesized using suspension polymerization method, with an increase in structural disorder observed at a slower rate with higher VdF content in the copolymer. The copolymer with the highest VdF content showed similar crystallinity before and after the stimulus, indicating good thermal stability and microvoid tolerance.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Article
Biochemistry & Molecular Biology
Ashish K. Solanki, Pankaj Srivastava, Bushra Rahman, Joshua H. Lipschutz, Deepak Nihalani, Ehtesham Arif
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Ashish K. Solanki, Altaf A. Kondkar, Joseph Fogerty, Yanhui Su, Seok-Hyung Kim, Joshua H. Lipschutz, Deepak Nihalani, Brian D. Perkins, Glenn P. Lobo
Article
Multidisciplinary Sciences
Navdeep Kaur, Amin Sagar, Pankaj Sharma, Ashish, Pratap Kumar Pati
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Surbhi Garg, Amin Sagar, Gayathri S. Singaraju, Rahul Dani, Naimat K. Bari, Athi N. Naganathan, Sabyasachi Rakshit
Summary: Research has shown that age-related hearing loss is associated with the S47P mutation in the cadherin-23 protein, leading to decreased stability and loss of correlated motions. These changes not only result in significantly slower folding in the mutant, but also affect the complex unfolding mechanism.
BIOCHEMICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Sumita Karan, Ankita Behl, Amin Sagar, Arkita Bandyopadhyay, Ajay K. Saxena
Summary: The study purified the Mycobacterium tuberculosis HddA enzyme, analyzed its structural and functional characteristics, and investigated the impact of various factors on its stability and activity. The results provide valuable insights into the structure and activity of MtbHddA, which could potentially be targeted for therapeutic development against tuberculosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Tanuja Joshi, Surbhi Garg, Alejandro Estana, Juan Cortes, Pau Bernado, Sayan Das, Anjana R. Kammath, Amin Sagar, Sabyasachi Rakshit
Summary: In polyproteins, the type of linker plays a significant role in the stability of domains. A linker rich in glycine can decrease domain stability, while interdomain interactions in glycine-rich linkers do not interfere with the stability of polyproteins. Flexible linkers are preferred for maintaining the independence of domains in a polyprotein.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ashish K. Solanki, Ehtesham Arif, Pankaj Srivastava, Christopher M. Furchtl, Bushra Rahman, Pei Wen, Avinash Singh, Lawrence B. Holzman, Wayne R. Fitzgibbon, Milos N. Budisavljevic, Glenn P. Lobo, Sang-Ho Kwon, Zhe Han, Matthew J. Lazzara, Joshua H. Lipschutz, Deepak Nihalani
Summary: NEPHRIN and NEPH1 act as receptor proteins for hepatocyte growth factor (HGF), undergo phosphorylation independently of other receptors, and are dephosphorylated by SH2 domain-containing protein tyrosine phosphatase-2. High affinity interactions between NEPHRIN/NEPH1 and HGF were observed, with HGF-induced phosphorylation playing a central role in podocyte repair.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Laura Del Amo-Maestro, Amin Sagar, Petr Pompach, Theodoros Goulas, Carsten Scavenius, Diego S. Ferrero, Mariana Castrillo-Briceno, Marta Taules, Jan J. Enghild, Pau Bernado, F. Xavier Gomis-Ruth
Summary: This study characterized the complex formed by AD13-MDTCS with a vWF peptide, revealing tight binding and conformational changes. By integrating experimental and computational methods, insights into the interaction mechanism and structural patterns were provided.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Ashish K. Solanki, Manas R. Biswal, Stephen Walterhouse, Rene Martin, Altaf A. Kondkar, Hans-Joachim Knolker, Bushra Rahman, Ehtesham Arif, Shahid Husain, Sandra R. Montezuma, Deepak Nihalani, Glenn Prazere Lobo
Summary: The unconventional myosin MYO1C plays a crucial role in rhodopsin localization to photoreceptor outer segments and is essential for normal visual function. Loss of MYO1C in mice leads to rhodopsin mislocalization, impaired photoreceptor function, and progressively shorter outer segments, indicating its significance in retinal cell physiology.
Article
Chemistry, Analytical
Guillermo Iruela, Alejandro Fernandez, Amin Sagar, Francisco Javier Carvajal, Pau Bernado, Miquel Pons
Summary: In signaling proteins, intrinsically disordered regions are regulatory elements sensitive to environmental effects, ligand binding, and post-translational modifications. We have designed a biosensor for the N-terminal regulatory element of c-Src kinase and used it for drug screening.
Review
Genetics & Heredity
Rakesh Radhakrishnan, Venkateshwara R. Dronamraju, Matthias Leung, Andrew Gruesen, Ashish K. Solanki, Stephen Walterhouse, Heidi Roehrich, Grace Song, Rafael da Costa Monsanto, Sebahattin Cureoglu, Rene Martin, Altaf A. Kondkar, Frederik J. van Kuijk, Sandra R. Montezuma, Hans-Joachim Knoelker, Robert B. Hufnagel, Glenn P. Lobo
Summary: This article discusses the mechanisms of protein transport within photoreceptor cells, and introduces a novel role for an unconventional motor protein, MYO1C, in driving the transport of the visual chromophore Rhodopsin to the outer segments.
OPHTHALMIC GENETICS
(2022)
Article
Biotechnology & Applied Microbiology
Paula M. Corsini, Sunjun Wang, Saima Rehman, Katherine Fenn, Amin Sagar, Slobodan Sirovica, Leanne Cleaver, Charlotte J. C. Edwards-Gayle, Giulia Mastroianni, Ben Dorgan, Lee M. Sewell, Steven Lynham, Dinu Iuga, W. Trent Franks, James Jarvis, Guy H. Carpenter, Michael A. Curtis, Pau Bernado, Vidya C. Darbari, James A. Garnett
Summary: This study investigates the role of SslE protein in biofilm formation in Escherichia coli. The findings reveal that SslE has a unique and dynamic structure and can form aggregates with amyloid-like properties under acidic conditions. Additionally, SslE interacts with DNA and co-localizes with extracellular DNA in biofilms, suggesting its importance in biofilm maturation in various E. coli strains.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Chemistry, Multidisciplinary
Franck Bertorelle, K. David Wegner, Martina Peric Bakulic, Hussein Fakhouri, Clothilde Comby-Zerbino, Amin Sagar, Pau Bernado, Ute Resch-Genger, Vlasta Bonacic-Koutecky, Xavier Le Guevel, Rodolphe Antoine
Summary: Atomically precise gold nanoclusters with molecule-like properties and outstanding photoluminescence (PL) are highly attractive for selective biomolecule labeling in biological mechanism investigations. In this study, a simple method to incorporate a preformed Au-25 nanocluster into bovine serum albumin (BSA) protein was reported. The combination of small-angle X-ray scattering and molecular modeling successfully localized a single Au-25 within the protein to a cysteine residue on the gold nanocluster surface. Attaching Au-25 to BSA significantly modified the PL properties, resulting in enhancement and a redshift in the second near-infrared window. This research paves the way for the design of selective sensitive probes using a ligand-based strategy for optical detection of biomolecules in a cellular environment by live imaging.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Nicolas S. Gonzalez-Foutel, Juliana Glavina, Wade M. Borcherds, Matias Safranchik, Susana Barrera-Vilarmau, Amin Sagar, Alejandro Estana, Amelie Barozet, Nicolas A. Garrone, Gregorio Fernandez-Ballester, Clara Blanes-Mira, Ignacio E. Sanchez, Gonzalo De Prat-Gay, Juan Cortes, Pau Bernado, Rohit Pappu, Alex S. Holehouse, Gary W. Daughdrill, Lucia B. Chemes
Summary: This study identifies the molecular mechanism of functional selection in disordered proteins and highlights the importance of conformational buffering and motif-linker coevolution for functional encoding.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2022)
Article
Biology
Cheerneni S. S. Srinivas, Gayathri S. S. Singaraju, Veerpal Kaur, Sayan Das, Sanat K. Ghosh, Amin Sagar, Anuj Kumar, Tripta Bhatia, Sabyasachi Rakshit
Summary: Cis and trans interactions among cadherins play a role in securing multicellularity. In this study, researchers found that weak hydrophobic interactions can drive the lateral clustering of cadherin-23 on a membrane. This clustering accelerates cell-cell adhesion and strengthens cell junctions.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
