Weakening of interaction networks with aging in tip-link protein induces hearing loss

c.753A>G genome editing of a Cdh23 allele delays age-related hearing loss and degeneration of cochlear hair cells in C57BL/6J mice

(2020) Shumpei P. Yasuda et al.   HEARING RESEARCH

Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception

(2020) Deepanshu Choudhary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for hearing

(2019) Tobias F. Bartsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inter-Active Site Communication Mediated by the Dimer Interface β-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase

(2019) Paul J. Sapienza et al.   BIOCHEMISTRY

Broken force dispersal network in tip-links by the mutations at the Ca2+-binding residues induces hearing-loss

(2019) Jagadish P. Hazra et al.   BIOCHEMICAL JOURNAL

Structural basis of the strong cell‐cell junction formed by cadherin‐23

(2019) Gayathri S. Singaraju et al.   FEBS Journal

CONAN: A Tool to Decode Dynamical Information from Molecular Interaction Maps

(2018) Davide Mercadante et al.   BIOPHYSICAL JOURNAL

Evolution of chemokine receptors is driven by mutations in the sodium binding site

(2018) Bruck Taddese et al.   PLoS Computational Biology

Tonotopy in calcium homeostasis and vulnerability of cochlear hair cells

(2018) Robert Fettiplace et al.   HEARING RESEARCH

Modulation of allosteric coupling by mutations: from protein dynamics and packing to altered native ensembles and function

(2018) Athi N Naganathan   CURRENT OPINION IN STRUCTURAL BIOLOGY

Quantifying Allosteric Communication via Both Concerted Structural Changes and Conformational Disorder with CARDS

(2017) Sukrit Singh et al.   Journal of Chemical Theory and Computation

Protein Frustratometer 2: a tool to localize energetic frustration in protein molecules, now with electrostatics

(2016) R. Gonzalo Parra et al.   NUCLEIC ACIDS RESEARCH

Characterization of Disease-Associated Mutations in Human Transmembrane Proteins

(2016) János Molnár et al.   PLoS One

Sound localization in the alligator

(2015) Hilary S. Bierman et al.   HEARING RESEARCH

On Human Disease-Causing Amino Acid Variants: Statistical Study of Sequence and Structural Patterns

(2015) Marharyta Petukh et al.   HUMAN MUTATION

High prevalence of CDH23 mutations in patients with congenital high-frequency sporadic or recessively inherited hearing loss

(2015) Kunio Mizutari et al.   Orphanet Journal of Rare Diseases

The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS

(2015) James M. Aramini et al.   STRUCTURE

Integrating protein structural dynamics and evolutionary analysis with Bio3D

(2014) Lars Skjærven et al.   BMC BIOINFORMATICS

PyInteraph: A Framework for the Analysis of Interaction Networks in Structural Ensembles of Proteins

(2014) Matteo Tiberti et al.   Journal of Chemical Information and Modeling

Audiogram of the chicken (Gallus gallus domesticus) from 2 Hz to 9 kHz

(2014) Evan M. Hill et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY

Correlated motions are a fundamental property of β-sheets

(2014) R. Bryn Fenwick et al.   Nature Communications

Comparing a simple theoretical model for protein folding with all-atom molecular dynamics simulations

(2013) E. R. Henry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

xPyder: A PyMOL Plugin To Analyze Coupled Residues and Their Networks in Protein Structures.

(2012) Marco Pasi et al.   Journal of Chemical Information and Modeling

Predictions from an Ising-like Statistical Mechanical Model on the Dynamic and Thermodynamic Effects of Protein Surface Electrostatics

(2012) Athi N. Naganathan   Journal of Chemical Theory and Computation

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction

(2012) Marcos Sotomayor et al.   NATURE

Relationship Between Age of Hearing-Loss Onset, Hearing-Loss Duration, and Speech Recognition in Individuals with Severe-to-Profound High-Frequency Hearing Loss

(2011) Fabien Seldran et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs

(2010) F Han et al.   PHARMACOGENOMICS JOURNAL

Entropic mechanism of large fluctuation in allosteric transition

(2010) Kazuhito Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sop-GPU: Accelerating biomolecular simulations in the centisecond timescale using graphics processors

(2010) A. Zhmurov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS