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Cell Biology
Hongyan Wang, Jie Ai, Abdullah Shopit, Mengyue Niu, Nisar Ahmed, Tsehaye Tesfaldet, Zhongyuan Tang, Xiaodong Li, Yazeed Jamalat, Peng Chu, Jinyong Peng, Xiaodong Ma, Eskandar Qaed, Guozhu Han, Weisheng Zhang, Jun Wang, Zeyao Tang
Summary: PCr protects pancreatic beta-cells from diabetes-induced mitochondrial damage by regulating multiple signaling pathways like AKT/IRS-1/GSK-3 beta and STAT3/Cyp-D, inhibiting apoptosis and restoring mitochondrial function.
CELL BIOLOGY AND TOXICOLOGY
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Cell Biology
Lu Jin, Wei Zhang, Ming-Yu Yao, Ye Tian, Bo-xin Xue, Wei Tao
Summary: GNE-493 is a novel PI3K/mTOR dual inhibitor that effectively inhibits the growth and migration of prostate cancer cells through Akt-mTOR-dependent and -independent mechanisms.
CELL DEATH DISCOVERY
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Cardiac & Cardiovascular Systems
Antje Schauer, Peggy Barthel, Volker Adams, Axel Linke, David M. Poitz, Christof Weinbrenner
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JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
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Pharmacology & Pharmacy
Xia Jiang, Ye Lin, Mengting Zhao, Youhong Li, Renzhi Pei, Ying Lu, Lei Jiang
Summary: Acute myeloid leukemia (AML) is a highly heterogeneous and rapidly progressive hematopoietic neoplasm. Platycodin D (PD), extracted from traditional Chinese medicine, has shown therapeutic potential against a broad range of cancers. This study found that PD reduced the viability of AML cell lines through apoptosis induction, cell cycle arrest, and inhibition of specific signaling pathways. Combination therapy with PD and a BCL2 inhibitor showed enhanced cytotoxic effects, and the anti-leukemic activity of PD was validated using primary samples from AML patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
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Plant Sciences
Chengjian Li, Ying Wang, Chenxi Wu, Jin Zhou, Yanqing Zhou, Yang Jiao, Yamei Li, Liang Zhao
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Pharmacology & Pharmacy
Nuray Uremis, Yusuf Turkoz, Muhammed Mehdi Uremis, Yilmaz Cigremis, Emine Salva
Summary: In this study, the anticarcinogenic effects of sorafenib-cucurbitacin D and sorafenib-cucurbitacin I combination on HepG2 cell line were investigated. The results showed that the combination of cucurbitacin D and I with sorafenib had a synergistic effect, inhibiting cell proliferation, migration, and angiogenesis.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
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Cell Biology
Muhammad Imran, Joon Seong Park, In Kyoung Lim
CELLULAR SIGNALLING
(2015)
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Cell Biology
Yun Yeong Lee, Hong Seok Kim, In Kyoung Lim
CELLULAR SIGNALLING
(2015)
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Cell Biology
Ok Ran Choi, Min Sook Ryu, In Kyoung Lim
CELLULAR SIGNALLING
(2016)
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Oncology
Santhoshkumar Sundaramoorthy, Preethi Devanand, Min Sook Ryu, Kye Yong Song, Dong Young Noh, In Kyoung Lim
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2018)
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Oncology
Yong Won Choi, In Kyoung Lim
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Oncology
Young Hwa Kim, Myoung Ho Choi, Jang-Hee Kim, In Kyoung Lim, Tae Jun Park
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Cell Biology
Santhoshkumar Sundaramoorthy, Min Sook Ryu, In Kyoung Lim
CELL COMMUNICATION AND SIGNALING
(2013)
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Cell Biology
Muhammad Imran, In Kyoung Lim
CELLULAR SIGNALLING
(2013)
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Cell Biology
Linh Nguyen Quy, Yong Won Choi, Yeong Hwa Kim, Yong-Joon Chwae, Tae Jun Park, In Kyoung Lim
CELLULAR SIGNALLING
(2013)
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Oncology
Min Sook Ryu, Min-Yeong Woo, Daeho Kwon, Allen E. Hong, Kye Yong Song, Sun Park, In Kyoung Lim
EXPERIMENTAL CELL RESEARCH
(2014)
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Biochemistry & Molecular Biology
Preethi Devanand, Sun Il Kim, Yong Won Choi, Seung Soo Sheen, Hyunee Yim, Min Sook Ryu, Se Joong Kim, Wun-Jae Kim, In Kyoung Lim
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Biochemistry & Molecular Biology
Yuna Kim, Jewon Ryu, Min Sook Ryu, Sunny Lim, Ki Ok Han, In Kyoung Lim, Ki Hoon Han
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Oncology
Eung-Gook Kim, Hiroyuki Seimiya, Junho Chung, Joeerg Hoheisel, In Kyoung Lim, Hirota Fujiki, Sang Chul Park
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2013)
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Cell Biology
Jae-Il Park, Sun-Gyun Kim, Min Woo Baek, Tae Jun Park, In Kyoung Lim, Young-Woo Seo, Sang-Young Chun
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2013)
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Medicine, General & Internal
Woon Ki Paik, Sangduk Kim, In Kyoung Lim
YONSEI MEDICAL JOURNAL
(2014)
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Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
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Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)