Investigating EGFR-VEGF-mediated apoptotic effect of cucurbitacin D and I combination with sorafenib via Ras/Raf/MEK/ERK and PI3K/Akt signaling pathways
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Investigating EGFR-VEGF-mediated apoptotic effect of cucurbitacin D and I combination with sorafenib via Ras/Raf/MEK/ERK and PI3K/Akt signaling pathways
Authors
Keywords
-
Journal
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-11-02
DOI
10.1007/s00210-023-02811-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cucurbitacin E shows synergistic effect with sorafenib by inducing apoptosis in hepatocellular carcinoma cells and regulates Jak/Stat3, ERK/MAPK, PI3K/Akt/mTOR signaling pathways
- (2023) Muhammed Mehdi Üremiş et al. STEROIDS
- Cucurbitacins and the Immune System: Update in Research on Anti-inflammatory, Antioxidant, and Immunomodulatory Mechanisms
- (2022) Geovana F. Guedes Silvestre et al. CURRENT MEDICINAL CHEMISTRY
- Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents
- (2022) Sheema Hashem et al. BIOMEDICINE & PHARMACOTHERAPY
- Cucurbitacin D inhibits the proliferation of HepG2 cells and induces apoptosis by modulating JAK/STAT3, PI3K/Akt/mTOR and MAPK signaling pathways
- (2022) Muhammed Mehdi Üremiş et al. CURRENT CANCER DRUG TARGETS
- Cucurbitacin I exhibits anticancer efficacy through induction of apoptosis and modulation of JAK / STAT3 , MAPK / ERK , and AKT / mTOR signaling pathways in HepG2 cell line
- (2022) Nuray Üremiş et al. JOURNAL OF FOOD BIOCHEMISTRY
- Pharmacokinetics and Biological Activity of Cucurbitacins
- (2022) Eugenia Elisa Delgado-Tiburcio et al. Pharmaceuticals
- Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms
- (2022) Carla Varela et al. Journal of Translational Medicine
- Updated Insights on EGFR Signaling Pathways in Glioma
- (2021) Alexandru Oprita et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress
- (2021) Eyup Altinoz et al. DRUG AND CHEMICAL TOXICOLOGY
- Strategies to overcome drug resistance using SHP2 inhibitors
- (2021) Meng Liu et al. Acta Pharmaceutica Sinica B
- Emerging treatment modalities for systemic therapy in hepatocellular carcinoma
- (2021) Xin Qing et al. Biomarker Research
- Antiproliferative evaluation of some 2‐(2‐Styrylcyclopent‐3‐enyl) benzo[d]thiazoles: DFT and molecular docking study
- (2020) Mustafa Ceylan et al. CHEMISTRY & BIODIVERSITY
- Molecular Signaling Pathways and Therapeutic Targets in Hepatocellular Carcinoma
- (2020) Manali Dimri et al. Cancers
- Cucurbitacin D Overcomes Gefitinib Resistance by Blocking EGF Binding to EGFR and Inducing Cell Death in NSCLCs
- (2020) Se Hyang Hong et al. Frontiers in Oncology
- Novel systemic therapy for hepatocellular carcinoma
- (2020) Yawen Dong et al. Hepatology International
- Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis
- (2020) Ruli Li et al. Molecular Medicine Reports
- Cucurbitacin D Induces G2/M Phase Arrest and Apoptosis via the ROS/p38 Pathway in Capan-1 Pancreatic Cancer Cell Line
- (2020) Myeong-Sun Kim et al. Evidence-based Complementary and Alternative Medicine
- Relevance of EGFR Between Serum VEGF and MMP-9 in Primary Hepatocellular Carcinoma Patients with Transarterial Chemoembolization
- (2020) Shengya Cao et al. OncoTargets and Therapy
- Cucurbitacins: Bioactivities and synergistic effect with small-molecule drugs
- (2020) Siyuan Jing et al. Journal of Functional Foods
- Cucurbitacin E Induces Autophagy-Involved Apoptosis in Intestinal Epithelial Cells
- (2020) Huapei Song et al. Frontiers in Physiology
- Sorafenib and CuB exert synergistic antitumor effects against hepatocellular carcinoma cells via inhibition of STAT3 phosphorylation
- (2020) Xiaoli Wang et al. FEBS Open Bio
- Cucurbitacin mediated regulation of deregulated oncogenic signaling cascades and non-coding RNAs in different cancers: Spotlight on JAK/STAT, Wnt/β-catenin, mTOR, TRAIL-mediated pathways
- (2020) Xiukun Lin et al. SEMINARS IN CANCER BIOLOGY
- Nanotubular TiO2 regulates macrophage M2 polarization and increases macrophage secretion of VEGF to accelerate endothelialization via the ERK1/2 and PI3K/AKT pathways
- (2019) Wei-Chang Xu et al. International Journal of Nanomedicine
- Hepatocellular Carcinoma: Molecular Mechanisms and Targeted Therapies
- (2019) Alqahtani et al. Medicina-Lithuania
- Natural product derived privileged scaffolds in drug discovery
- (2019) Emma K Davison et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1–Parkin pathway and modulate cellular drug response
- (2017) Conggang Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The protective role of G protein-coupled estrogen receptor 1 (GPER-1) on methotrexate-induced nephrotoxicity in human renal epithelium cells
- (2016) Akif Hakan Kurt et al. RENAL FAILURE
- Hepatocellular carcinoma
- (2016) Josep M. Llovet et al. Nature Reviews Disease Primers
- Novel combination of sorafenib and biochanin-A synergistically enhances the anti-proliferative and pro-apoptotic effects on hepatocellular carcinoma cells
- (2016) Mohieldin M. Youssef et al. Scientific Reports
- Ras activation revisited: role of GEF and GAP systems
- (2015) Anne Hennig et al. BIOLOGICAL CHEMISTRY
- Global cancer statistics, 2012
- (2015) Lindsey A. Torre et al. CA-A CANCER JOURNAL FOR CLINICIANS
- The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications
- (2015) Bénédicte Delire et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer
- (2015) JUNMIN SONG et al. ONCOLOGY REPORTS
- Silencing Alpha-Fetoprotein Inhibits VEGF and MMP-2/9 Production in Human Hepatocellular Carcinoma Cell
- (2014) Wenbo Meng et al. PLoS One
- Clinical Trials in Hepatocellular Carcinoma: An Update
- (2013) Ying-Chun Shen et al. Liver Cancer
- Cucurbitacin D induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial and ovarian cancer cells
- (2012) Terukazu Ishii et al. TUMOR BIOLOGY
- Global cancer statistics
- (2011) Ahmedin Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
- PKI-587 and Sorafenib Targeting PI3K/AKT/mTOR and Ras/Raf/MAPK Pathways Synergistically Inhibit HCC Cell Proliferation
- (2011) Roberto Gedaly et al. JOURNAL OF SURGICAL RESEARCH
- Targeting renal cell carcinoma with NVP-BEZ235, a dual PI3K/mTOR inhibitor, in combination with sorafenib
- (2011) Didier Roulin et al. Molecular Cancer
- Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
- (2010) T.-C. Chou CANCER RESEARCH
- Angiogenesis: From Chronic Liver Inflammation to Hepatocellular Carcinoma
- (2010) Paloma Sanz-Cameno et al. Journal of Oncology
- Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562
- (2009) Kin Tak Chan et al. CANCER LETTERS
- Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
- (2008) Ann-Lii Cheng et al. LANCET ONCOLOGY
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now