Article
Multidisciplinary Sciences
Qinjuan Wu, Xin Li, Menghong Long, Xianfeng Xie, Qing Liu
Summary: Histone Kla is found to play a crucial role in the tumorigenesis of hepatocellular carcinoma (HCC), and it can serve as an independent biomarker. NR6A1, OSBP2, and UNC119B are associated with prognosis, immunotherapy, and chemotherapy resistance in HCC. These findings provide potential novel therapeutic targets for HCC.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Juan Wang, Zeyuan Cao, Panpan Wang, Xiao Zhang, Jianxia Tang, Yifan He, Zhiqing Huang, Xueli Mao, Songtao Shi, Xiaoxing Kou
Summary: The study demonstrates that apoEVs can induce multiple myeloma cell apoptosis and inhibit tumor growth, suggesting a potential therapeutic use of apoEVs for MM treatment.
Article
Anatomy & Morphology
Zhengguang Wang, Yongfang Tan, Fei Xu
Summary: This study aimed to investigate the effects of zonisamide (ZNS) on a degenerative cervical myelopathy (DCM) rat model and explore the potential mechanisms. The results showed that ZNS promoted motor recovery, reversed histopathological injury and cell apoptosis in DCM rats. Additionally, ZNS attenuated DCM injury through the regulation of Fas and FasL signaling. Therefore, this study provided a new theoretical approach for subsequent academic and clinical research on DCM injury.
Article
Cell Biology
Qi Zhang, Xinqi Zhang, Weiguo Dong
Summary: TRAF7 overexpression in HCC promotes cell proliferation, invasion, migration, and inhibits apoptosis, while also driving P53 degradation, contributing to tumor progression. Targeting the TRAF7-P53 axis may provide new insights for HCC pathogenesis and novel strategies for prevention and treatment.
CELL DEATH DISCOVERY
(2021)
Article
Chemistry, Multidisciplinary
Jiranan Chotitumnavee, Yasunobu Yamashita, Yukari Takahashi, Yuri Takada, Tetsuya Iida, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki
Summary: A first-in-class proteolysis targeting chimera (PROTAC) was developed to selectively degrade HDAC8, without affecting other HDACs, and exhibited stronger growth inhibition in T-cell leukemia Jurkat cells compared to a conventional HDAC8 inhibitor.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kohta Takahashi, Kristiina Kanerva, Lauri Vanharanta, Leonardo Almeida-Souza, Daniel Lietha, Vesa M. Olkkonen, Elina Ikonen
Summary: The study reveals the mechanism by which ORP2 regulates lipid and protein trafficking in cells, controlling FAK activation and LDL-cholesterol plasma membrane delivery by facilitating cholesterol and PI(4,5)P-2 exchange between late and recycling endosomes.
Review
Pharmacology & Pharmacy
Vesa M. Olkkonen
Summary: Oxysterol-binding protein-related proteins (ORPs) are a family of intracellular lipid binding/transfer proteins involved in lipid transport within cells. They have the ability to bind phosphatidylinositol polyphosphates (PIPs). Dysregulation of certain ORP family members, such as ORP3, -4, -5, and -8, is implicated in cancer growth through their effects on signaling events, protein interactions, and cellular lipid transport. This review discusses the functional evidence of ORPs in cancer growth and explores the potential of targeting ORPs for anti-cancer therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Jian-Long Li, Jing-Fang Yang, Li-Ming Zhou, Meng Cai, Zhong-Qiao Huang, Xi-Li Liu, Xiao-Lei Zhu, Guang-Fu Yang
Summary: Oomycetes, particularly Phytophthora species, pose significant threats to global food security and natural ecosystems. This study used AlphaFold 2 to generate the OSBP model of Phytophthora capsici and investigated the binding mechanism of the fungicide OXA. Based on this, a series of OXA analogues were designed, and compound 2l showed comparable control efficiency to OXA. The findings suggest that 2l could serve as a lead compound for the development of new OSBP fungicides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Yuta Kono, Thomas Colley, Masako To, Andriana I. Papaioannou, Nicolas Mercado, Jonathan R. Baker, Yasuo To, Shinji Abe, Kosuke Haruki, Kazuhiro Ito, Peter J. Barnes
Summary: Cigarette smoke impairs cellular autophagy, leading to increased levels of galectin-8, which may be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Noor Mustafa, Jone Mitxelena, Arantza Infante, Olatz Zenarruzabeitia, Ainhoa Eriz, Ainhoa Iglesias-Ara, Ana M. Zubiaga
Summary: Disruption of E2f2 in mice leads to T-cell hyperactivation and disproportionate cell cycle entry. However, E2f2(-/-) mice do not develop lymphoproliferative condition. We find that E2f2 plays an anti-apoptotic role through the Fas pathway in vitro and in vivo. Knockout of E2f2 in TCR-stimulated T cells results in overexpression of proapoptotic genes, enhanced apoptosis, and activated p53 pathway. However, E2f2-Fas/FasL signaling is p53-independent. E2f2 is recruited to Fas and FasL gene promoters to repress their expression. E2f2(-/-) mice are prone to immune-mediated liver injury due to aberrant lymphoid Fas/FasL activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Su Hyun Lee, Won Jin Cho, Abdo J. Najy, Allen-Dexter Saliganan, Tri Pham, Joseph Rakowski, Brian Loughery, Chang Hoon Ji, Wael Sakr, Seongho Kim, Ikuko Kato, Weon Kuu Chung, Harold E. Kim, Yong Tae Kwon, Hyeong-Reh C. Kim
Summary: The study revealed that increased autophagic flux and defective apoptosis are associated with radioresistance in HPV(-) HNSCC, while HPV(+) HNSCC easily undergo apoptotic cell death upon radiation treatments without inducing autophagic flux. Activation of the p62-ZZ domain can sensitize radioresistant HPV(-) HNSCC cells to ionizing radiation by promoting p62 self-polymerization and sequestration of cargoes leading to apoptosis. Harnessing p62-dependent sequestration of ubiquitinated caspase-8 provides a novel therapeutic avenue in patients with radioresistant tumors.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Wei Wei, Sophie T. Yount, Zachary D. Allen, Katherine F. Bechdol, Weiming Xia, Huanbiao Mo, Angela M. Mabb
Summary: Synaptic dysfunction is a common feature of aging and neurological disorders, and dysregulation of AMPA receptors is an underlying mechanism. Tocotrienols, vitamin E molecules, have been shown to improve cognitive function and reduce amyloid secretion. The study found that 8-tocotrienol increased surface levels of GluA1, decreased phosphorylation of GluA1 at Serine 845, and enhanced AMPA receptor-mediated neurotransmission. These findings suggest that 8-tocotrienol may be beneficial in ameliorating synaptic dysfunction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Toxicology
Xue Fan, Yangping Zhu, Shuang Peng, Yingying Miao, Qian Lu, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
Summary: This study found that triptolide (TP) enhances the sensitivity of liver cells to the Fas/FasL pathway by inhibiting the expression of anti-apoptotic protein XIAP, leading to apoptosis of liver cells. This is of great significance for explaining the hepatotoxic mechanism of TP.
TOXICOLOGY LETTERS
(2023)
Article
Virology
Xiazhen Xu, Lu Zhang, Guiying Ye, Jiajian Shi, Yibin Peng, Fan Xin, Yi Lin, Qiong Wu, Xu Lin, Wannan Chen
Summary: The study reveals that the 2.2-kb HBV spliced variants encoded protein, HBDSP, promotes apoptosis in wt-p53 hepatocytes and induces the activation of p53-dependent apoptotic signaling pathway. Additionally, HBDSP increases the production of HBV progeny and viral antigens through the transactivation of the p53 promoter in an ETS1-, GATA2-, and YY1-dependent manner.
JOURNAL OF VIROLOGY
(2023)
Article
Cell Biology
Ling Ye, Yuan Shi, Huifeng Zhang, Chao Chen, Jingjing Niu, Jianxu Yang, Zhifeng Li, Huanzhang Shao, Bingyu Qin
Summary: Intra-abdominal infections are a common cause of sepsis in ICU, causing intestinal epithelial injury and leading to persistent inflammation and organ dysfunction. This study investigates the role of circFLNA in intestinal epithelial apoptosis during sepsis. The findings suggest that circFLNA promotes intestinal injury in abdominal sepsis through the Fas-mediated apoptosis pathway by sponging miR-766-3p, highlighting its potential as a therapeutic target for sepsis-induced intestinal injury.
INFLAMMATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Wenbin Zhong, Guoping Pan, Lin Wang, Shiqian Li, Jingsong Ou, Mengyang Xu, Jiwei Li, Biying Zhu, Xiuye Cao, Hongling Ma, Chaowen Li, Jun Xu, Vesa M. Olkkonen, Bart Staels, Daoguang Yan
CIRCULATION RESEARCH
(2016)
Article
Multidisciplinary Sciences
Wenbin Zhong, Qing Yi, Bing Xu, Shiqian Li, Tong Wang, Fupei Liu, Biying Zhu, Peter R. Hoffmann, Guangju Ji, Pingsheng Lei, Guoping Li, Jiwei Li, Jian Li, Vesa M. Olkkonen, Daoguang Yan
NATURE COMMUNICATIONS
(2016)
Article
Oncology
Ji-Wei Li, Yan-Lin Xiao, Chao-Feng Lai, Ning Lou, Hong-Ling Ma, Bi-Ying Zhu, Wen-Bin Zhong, Dao-Guang Yan
Article
Biochemistry & Molecular Biology
Biying Zhu, Xiuye Cao, Wenqiang Zhang, Guoping Pan, Qing Yi, Wenbin Zhong, Daoguang Yan
Article
Cell Biology
Wenbin Zhong, Mengyang Xu, Chanjuan Li, Biying Zhu, Xiuye Cao, Dan Li, Huanzhao Chen, Chunxiu Hu, Rong Li, Chengwei Luo, Guoping Pan, Wenqiang Zhang, Chaofeng Lai, Tong Wang, Xin Du, Hong Chen, Guowang Xu, Vesa M. Olkkonen, Pingsheng Lei, Jun Xu, Daoguang Yan
Article
Immunology
Mengyang Xu, Biying Zhu, Xiuye Cao, Shannai Li, Dan Li, Huihao Zhou, Vesa M. Olkkonen, Wenbin Zhong, Jun Xu, Daoguang Yan
JOURNAL OF IMMUNOLOGY
(2020)
Article
Chemistry, Medicinal
Mengyang Xu, Chao Zhao, Biying Zhu, Liangyue Wang, Huihao Zhou, Daoguang Yan, Qiong Gu, Jun Xu
Summary: The study introduces a new method for discovering potent Hsp90 inhibitors by assembling fragments, providing a novel approach for finding anti-nasopharyngeal carcinoma agents. Through chemotyping analysis and click chemistry, 15 anti-Hsp90 fragments were identified, 21 compounds were synthesized, and the more potent 4f inhibitor was discovered.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Biying Zhu, Wenbin Zhong, Xiuye Cao, Guoping Pan, Mengyang Xu, Jie Zheng, Huanzhao Chen, Xiaoqin Feng, Chengwei Luo, Chen Lu, Jie Xiao, Weize Lin, Chaofeng Lai, Mingchuan Li, Xin Du, Qing Yi, Daoguang Yan
Summary: miR-31-5p is reduced in leukemia stem cells (LSCs), and inhibiting miR-31-5p promotes the conversion of hematopoietic stem progenitor cells (HSPCs) to LSCs. Restoring miR-31-5p eliminates LSCs and inhibits acute myeloid leukemia (AML) progression.
SCIENCE TRANSLATIONAL MEDICINE
(2022)