Article
Medicine, Research & Experimental
Xingyu Du, Xueyuan Zhang, Jing Dong, Naiyi Zou, Dong Guo, Weinan Yao, Xiaobin Wang, Shuguang Li, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: High expression of plasma exosomal HMGB1 is associated with an adverse radiotherapy response in ESCC patients. IR-induced exosomal HMGB1 enhances the radioresistance of ESCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Wenwen Dong, Bei Luo, Chang Qiu, Xu Jiang, Bo Shen, Li Zhang, Weiguo Liu, Wenbin Zhang
Summary: The study demonstrates that TRIM3 may attenuate cell apoptosis in Parkinson's disease by activating the PI3K/AKT signaling pathway, thereby improving cell viability in PD.
Article
Medicine, Research & Experimental
Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu, Xuegong Fan
Summary: This study found that VCP is significantly increased in HCC tissues and is associated with advanced TNM stages and poorer prognosis. VCP overexpression promotes HCC cell proliferation, migration, and invasion via PI3K/AKT/mTOR pathway activation. Additionally, VCP interacts with HMGB1 and enhances its protein stability, contributing to HCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Environmental Sciences
Ming-Ming Zhang, Li-Yan An, Wen-Xiang Hu, Zhong-Yang Li, Yu-Yun Qiang, Bao-Yu Zhao, Tie-Suo Han, Chen-Chen Wu
Summary: This study investigated the effects of endotoxin exposure on the reproductive performance of humans and animals during pregnancy and delivery. The results showed that gland cells secreted glycosaminoglycan particles into the uterine cavity to increase the thickness of the mucus layer and protect the uterus. This process was found to be regulated by the PI3K/AKT signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Medicine, Research & Experimental
Ayman E. El-Sahar, Nadine Bekhit, Noha M. Eissa, Rania M. Abdelsalam, Reham M. Essam
Summary: The study investigated the effects of Vildagliptin on testosterone-induced BPH in rats and its mechanisms. Results showed that Vildagliptin significantly reduced prostate weight, prostate index, PSA levels, 5 alpha-reductase activity, and DHT levels. It also inhibited inflammation-related signaling pathways and improved oxidative stress markers. Vildagliptin could be a potential preventive approach for BPH.
Article
Biochemistry & Molecular Biology
Xueyuan Zhang, Naiyi Zou, Wenzhao Deng, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: This study found that down-regulation of HMGB1 can promote the radiosensitivity of esophageal cancer cells through regulating the PI3K/Akt/ATM pathway, leading to improved prognosis for patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Fisheries
Chang Ding, Xu Shi, Yalin Guan, Xiaojing Li
Summary: Exposure to DON can cause neutrophil death by activating CYP450s/ROS signal, inhibiting the RI3K/AKT pathway, inducing apoptosis and necroptosis, in a dose-dependent manner. These findings offer new insights into the toxicological effects of mycotoxins.
Article
Cell Biology
OEzge Boyacioglu, Elif Bilgic, Cem Varan, Erem Bilensoy, Emirhan Nemutlu, Duygu Sevim, Cetin Kocaefe, Petek Korkusuz
Summary: Therapeutic agents for NSCLC have limited efficacy and may cause serious adverse effects. Cannabinoid ligands, particularly ACPA, have shown promise in inhibiting proliferation and inducing apoptosis in NSCLC cells. Activation of pro-apoptotic pathways and inhibition of key metabolic processes by ACPA suggest its potential as a novel therapy for NSCLC.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Wenjuan Wang, Fanyan Zheng, Aihua Zhang
Summary: Sub-chronic arsenic exposure triggers inflammatory response and collagen fiber deposition in rat lung tissue, potentially through activation of the pro-inflammatory-related HMGB1/RAGE pathway and initiation of the PI3K/AKT and TGF-beta 1/SMAD pathways.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Fisheries
Xuan lihui, Guo Jinming, Guan Yalin, Wang Hemeng, Wu Hao, Chang Ying
Summary: Profenofos (PFF) as an environmental pollutant can induce oxidative stress in hepatocytes, inhibit AKT phosphorylation, and activate mitochondrial apoptosis. Albicanol can significantly reduce the effects of PFF on grass carp hepatocytes by regulating the ROS/PTEN/PI3K/AKT pathway.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Environmental Sciences
Xiaoru Chang, Xiujuan Wang, Jiangyan Li, Mengting Shang, Shuyan Niu, Wenli Zhang, Yunjing Li, Zuoyi Sun, Junying Gan, Wenhua Li, Meng Tang, Yuying Xue
Summary: This study found that AgNPs can induce cytotoxicity in HT22 cells through autophagy and apoptosis pathways mediated by the PI3K/AKT/mTOR signaling pathway. These results provide experimental evidence and explanation for the potential neurotoxicity triggered by AgNPs in vitro.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Oncology
Chunhui Nie, Bei Wang, Baoquan Wang, Ning Lv, Rui Yu, Enfan Zhang
Summary: The study revealed that protopine inhibits liver carcinoma cell viability by triggering apoptosis and suppressing the PI3K/Akt signaling pathway. In vivo experiments showed that protopine effectively repressed tumor growth without noticeable toxicity, indicating its potential as a therapeutic agent for liver carcinoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Thomas Gabriel Mhone, Ming-Cheng Chen, Chia-Hua Kuo, Tzu-Ching Shih, Chung-Min Yeh, Tso-Fu Wang, Ray-Jade Chen, Yu-Chun Chang, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study aimed to explore a tumor suppressive compound that can enhance the efficacy of Gefitinib treatment in lung cancer. Through in vitro and in vivo experiments, it was found that the combination of Daidzein and Gefitinib synergistically induced apoptosis and cell cycle arrest, effectively inhibiting lung cancer growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xin Chen, Qian Lin Song, Jia Yu Wang, Rui Ji, Ming Liang Cao, Duan Ying Guo, Yan Zhang, Jing Yang
Summary: This study demonstrates the involvement of FK506-binding protein 5 (FKBP5) in recurrent spontaneous abortion (RSA), suggesting its potential as a diagnostic and therapeutic target. FKBP5 upregulation at the placental interface contributes to the pathogenesis of RSA by impairing trophoblast function and promoting M1-type macrophage polarization. FKBP5 inhibits trophoblast IL-6 secretion and suppresses trophoblast function through the PI3K/AKT signaling pathway. Moreover, FKBP5 promotes M1 macrophage polarization in decidual macrophages via the ROS/NF-kappa B signaling pathway. FKBP5 inhibitors improve embryo resorption rate in a mouse model of miscarriage, emphasizing the importance of FKBP5 in maintaining pregnancy and trophoblast-macrophage crosstalk at the maternal-fetal interface.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Oncology
Liuyan Chen, Jilin Qing, Yangyang Xiao, Xiaomei Huang, Yanlin Chi, Zhizhong Chen
Summary: The study revealed that TIM-1 overexpression promoted cell migration and invasion, inhibited apoptosis in cervical cancer, and modulated the PI3K/AKT/p53 and PI3K/AKT/mTOR signaling pathways. It may serve as a candidate diagnostic biomarker for this disease.
Article
Virology
Yasmin Hisham, Yaqoub Ashhab, Sang-Hyun Hwang, Dong-Eun Kim
Summary: An in silico workflow pipeline was established to identify B-cell- and T-cell-stimulating antigens of SARS-CoV-2 viral proteins. Thirteen potential epitopes were selected as subunit vaccine candidates through a reverse vaccinology approach, despite mutational amino acid substitutions.
Review
Chemistry, Multidisciplinary
Kim-Hung Huynh, Eunil Hahm, Mi Suk Noh, Jong-Hwan Lee, Xuan-Hung Pham, Sang Hun Lee, Jaehi Kim, Won-Yeop Rho, Hyejin Chang, Dong Min Kim, Ahruem Baek, Dong-Eun Kim, Dae Hong Jeong, Seung-min Park, Bong-Hyun Jun
Summary: Magnetic plasmonic particles (MPPs) serve as an advanced SERS detection platform with synergistic effects of magnetic and plasmonic properties, offering functions such as separation, drug delivery, and therapeutic applications. Literature explores the structure and multifunctionality of MPPs, enabling novel applications in various biological fields.
Article
Biochemistry & Molecular Biology
Sumin Son, Ahruem Baek, Jong Hun Lee, Dong-Eun Kim
Summary: The study found that intermediate cytofilament keratin 8 (KRT8) interacts with the cytolinker plectin (PLEC) to facilitate autophagosome-lysosome fusion. Inhibition or disruption of this interaction attenuates the fusion process.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Analytical
Hyojin Lee, Hyobeen Lee, Sang-Hyun Hwang, Woong Jeong, Dong-Eun Kim
Summary: This study developed a new method for sensitive detection of SARS-CoV-2 viral RNA without thermal cycling. By using tandem isothermal gene amplification technology, this method can detect very low concentrations of viral RNA within 1 hour, and it has high sensitivity and accuracy for COVID-19 diagnosis.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biotechnology & Applied Microbiology
Sungje Bock, Yun-Sik Choi, Minhee Kim, Yewon Yun, Xuan-Hung Pham, Jaehi Kim, Bomi Seong, Wooyeon Kim, Ahla Jo, Kyeong-Min Ham, Sung Gun Lee, Sang Hun Lee, Homan Kang, Hak Soo Choi, Dae Hong Jeong, Hyejin Chang, Dong-Eun Kim, Bong-Hyun Jun
Summary: This paper reports a method to synthesize near-infrared (NIR) SERS nanoprobes SiO2@Au@Au NPs and achieve control over the nanogaps by adjusting the size of gold nanoparticles, resulting in effective SERS hotspots. SiO2@Au@Au NPs showed detectable in vivo SERS signals in animal tissue specimens and exhibited distinct SERS signals for different Raman label compounds injected into nude mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Minhee Kim, Jong Sam Lee, Wooyeon Kim, Jong Hun Lee, Bong-Hyun Jun, Keun-Sik Kim, Dong-Eun Kim
Summary: Cancer cells have immune evasion mechanisms that resist the immune cells by reprogramming the tumor microenvironment. This study designed a new drug delivery system, targeting breast cancer cells with multiple drugs, to reactivate the antitumor immune response and reverse the immunosuppressive tumor microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Boran Yoon, Yewon Yun, Kyung Bo Kim, Dong-Eun Kim
Summary: Excessive release of inflammatory cytokines can lead to chronic inflammation and inflammatory bowel disease. This study found that the immunoproteasome inhibitor YU102 can attenuate the assembly of NLRP3 inflammasome, inhibit the inflammatory cascade in intestinal epithelial cells, and suppress TNFα-induced epithelial-mesenchymal transition and increased cellular permeability.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kyeong-Min Ham, Minhee Kim, Sungje Bock, Jaehi Kim, Wooyeon Kim, Heung Su Jung, Jaehyun An, Hobeom Song, Jung-Won Kim, Hyung-Mo Kim, Won-Yeop Rho, Sang Hun Lee, Seung-Min Park, Dong-Eun Kim, Bong-Hyun Jun
Summary: A Cd-free quantum dot nanoprobe for bioimaging was fabricated by embedding multiple indium phosphide/zinc sulfide quantum dots onto silica templates and coating them with a silica shell. The resulting nanoparticles exhibited excellent optical properties and hydrophilicity, and showed prominent fluorescence signals in tumors, demonstrating their potential for bioimaging applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Jamin Ku, Khushbu Chauhan, Sang-Hyun Hwang, Yong-Joo Jeong, Dong-Eun Kim
Summary: Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification method that allows the simple, quick, and low-cost detection of various viral genes. However, LAMP assays are susceptible to generating non-specific amplicons. In this study, it was found that poly(ethylene glycol)-engrafted nanosized graphene oxide (PEG-nGO) can significantly enhance the specificity of LAMP by adsorbing surplus ssDNA primers, reducing non-specific annealing. The inclusion of PEG-nGO greatly improves the specificity and sensitivity of the LAMP assay, facilitating the detection of HCV-positive clinical samples with superior precision compared to RT-qPCR.
Article
Cell Biology
Byung-Kwon Jung, Yujin Park, Boran Yoon, Jin-Sil Bae, Seung-Woo Han, Ji-Eun Heo, Dong-Eun Kim, Kwon-Yul Ryu
Summary: LCN2 is a secretory protein produced by activated microglia and reactive astrocytes under neuroinflammatory stress conditions, leading to neuronal apoptosis. This study demonstrates that LCN2 secretion can be reduced by proteasome inhibition and autophagic flux activation in reactive astrocytes stimulated with lipopolysaccharide. The results suggest that modulating LCN2 production and secretion may offer a new therapeutic approach for neuroinflammatory diseases.
Review
Biochemistry & Molecular Biology
Jaehi Kim, Min-Sup Shin, Jonghyun Shin, Hyung-Mo Kim, Xuan-Hung Pham, Seung-min Park, Dong-Eun Kim, Young Jun Kim, Bong-Hyun Jun
Summary: Rapid, accurate, and convenient diagnosis is crucial for effective disease management, and lateral flow immunoassay (LFIA) with optical nanoparticles (NPs) has emerged as a major diagnostic tool. Researchers have developed various types of optical NPs with modified optical properties to serve as probes for LFIA. This review focuses on the literature about LFIA with optical NPs for specific target detection in diagnostics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Khushbu Chauhan, Dong-Min Kim, Eunbin Cho, Dong-Eun Kim
Summary: Quantitative real-time polymerase chain reaction (qPCR) is an important technique in medical and biotechnological applications. The addition of poly(ethylene glycol)-engrafted nanosized graphene oxide (PEG-nGO) can significantly improve the efficiency and specificity of qPCR. The use of PEG-nGO and DNA binding dye EvaGreen enhances the specificity and sensitivity of DNA amplification in the qPCR setup.
Article
Biochemistry & Molecular Biology
Eunbin Cho, Jayoung Namgung, Jong Sam Lee, Jinmin Jang, Bong-Hyun Jun, Dong-Eun Kim
Summary: Researchers have developed a simple method using mesoporous silica particles as RNA adsorbents to remove double-stranded RNA (dsRNA) impurities from synthesized RNA. Among various polyamines tested, spermidine showed superior capability of RNA binding to the silica matrix. By adjusting the EDTA concentration, at least 80% of the dsRNA can be removed from the mesoporous silica-adsorbed RNA. Compared to cellulose-based methods, using mesoporous silica particles with spermidine and EDTA for binding and elution, respectively, demonstrated more effective removal of dsRNA contaminants from synthesized RNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Kangwuk Kyung, Jamin Ku, Eunbin Cho, Junhyung Ryu, Jin Woo, Woong Jung, Dong-Eun Kim
Summary: We developed a fluorometric method for the accurate detection of single-nucleotide mutations in SARS-CoV-2 RNA using RNA sequence-dependent DNA ligation and tandem isothermal gene amplification methods. This method allows for high sensitivity identification of SARS-CoV-2 variants.
BIOENGINEERING-BASEL
(2023)
Review
Chemistry, Physical
Khushbu Chauhan, Jin Woo, Woong Jung, Dong-Eun Kim
Summary: This article reviews the recent advancements of PEGylated GO in gene/drug delivery and nucleic acid amplification techniques, highlighting its significant value in the field of biomedicine.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
