Article
Biochemistry & Molecular Biology
Linlin Zhang, Lu Chen, Dayong Tao, Fuchang Yu, Meng Qi, Shiwen Xu
Summary: Glyphosate can cause tissue damage such as liver and kidney in mammals. Tannin has anti-inflammatory, antibacterial and anti-inflammatory properties. However, the effect of glyphosate on the growth of L8824 cell line and the effect of tannin on antagonism of glyphosate through the ROS/PTEN/PI3K/AKT axis are unclear.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haoyu Zhang, Kexin Sun, Meichen Gao, Shiwen Xu
Summary: In this study, we found that zinc can antagonize the damaging effects of lead on testis cells through the ROS/PTEN/PI3K/AKT pathway, thus alleviating oxidative stress and apoptosis. These findings are important for understanding the toxic effects of lead and the protective role of zinc.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Toxicology
Mengmeng Gong, Zhiqiang Li, Xingxu Zhang, Baoxin Liu, Jiachen Luo, Xiaoming Qin, Yidong Wei
Summary: This study investigated the role of the PTEN/PI3K/AKT pathway in serum deprivation-induced cytotoxicity in H9c2 cells, finding that PTEN knockdown could reverse the related effects. The findings suggest that PTEN may play a crucial role in regulating cell apoptosis, ROS production, DNA damage, and cell proliferation under serum deficiency conditions.
TOXICOLOGY IN VITRO
(2021)
Article
Cell Biology
Wenwen Dong, Bei Luo, Chang Qiu, Xu Jiang, Bo Shen, Li Zhang, Weiguo Liu, Wenbin Zhang
Summary: The study demonstrates that TRIM3 may attenuate cell apoptosis in Parkinson's disease by activating the PI3K/AKT signaling pathway, thereby improving cell viability in PD.
Article
Cell Biology
Yan Sun, Huan Zhang, Junpeng Meng, Feng Guo, Dianyun Ren, Heshui Wu, Xin Jin
Summary: This study demonstrates that aberrant PCSK9 upregulation promotes cell proliferation and sorafenib resistance in HCC by inducing AKT activation. Additionally, competitive inhibition of PCSK9 palmitoylation enhances the antitumor effects of sorafenib in HCC.
Article
Environmental Sciences
Yiming Zhang, Zhaoyi Liu, Jing Lan, Jinliang Wang, Zhiqiang Shen, Guangliang Shi, Shu Li
Summary: Cadmium accumulation in pigs can induce apoptosis in thymus cells and activate oxidative stress pathways, leading to oxidative damage to immune tissues. Additionally, exposure to cadmium can affect antioxidant indices and alter the levels of related genes in the PTEN/PI3K/AKT pathway, ultimately impacting cell survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Caiying Zhang, Tianjin Lin, Gaohui Nie, Ruiming Hu, Shaoxing Pi, Zejing Wei, Chang Wang, Chenghong Xing, Guoliang Hu
Summary: The study revealed that the combination of Mo and Cd synergistically induces oxidative stress and triggers pyroptosis via the ROS/PTEN/PI3K/AKT axis in duck renal tubular epithelial cells.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Shengchen Wang, Hao Wu, Xu Shi, Yue Wang, Shiwen Xu
Summary: The production of plastics worldwide has played a crucial role in advancing modern society, but the increasing accumulation of plastics waste in oceans, soils, and other areas has become a major environmental and animal health concern. Our understanding of the toxicological effects of plastics, particularly microplastics (MPs), is still limited. This study revealed a hepatotoxicity phenomenon dominated by polystyrene (PS) MPs in mouse models and cellular assays. It was found that the level of liver cell injury caused by PS-MPs was negatively correlated with the size of the particles, with small-sized particles inducing necroptosis and large-sized particles inducing apoptosis. Inhibition of autophagy alleviated PS-MPs-induced cell death and altered the form of death injury to some extent. This study opens up new avenues for investigating the biological and toxicological effects of MPs, and provides valuable insights for preventing and mitigating the health hazards associated with MPs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Oncology
Xi Yu, Shenglan Li, Mingrui Pang, Yang Du, Tao Xu, Tao Bai, Kang Yang, Juncheng Hu, Shaoming Zhu, Lei Wang, Xiuheng Liu
Summary: This study revealed that downregulation of TSPAN7 in bladder cancer is associated with tumor progression and poor prognosis, and demonstrated the inhibitory effects of TSPAN7 on cancer cell proliferation and migration through multiple experiments. TSPAN7 inhibits bladder cancer cell growth by activating Bax, cleaved caspase-3, and PTEN pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Hongmin Lu, Kai Yin, Heng Su, Dongxu Wang, Yue Zhang, Lulu Hou, Jun Bo Li, Yu Wang, Mingwei Xing
Summary: This study found that polystyrene microplastics (PS-MPs) can cause lung injury in broiler chickens, leading to oxidative stress through inhibition of the PTEN/PI3K/AKT pathway and induction of autophagy and cell apoptosis. These results are of great significance to the toxicological study of PS-MPs and the protection of the ecosystem.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Hao Zhang, Huajun Sheng, Zhen Guo, Yu Xing, Qian Liu, Ziling Cai, Zihao Shen, Qingqian Xia, Shujuan Zhu
Summary: According to the study, AQP8 plays a significant role in the proliferation and growth of gliomas. Overexpression of AQP8 promotes cell proliferation, invasion, and migration, inhibits apoptosis, and affects the ROS/PTEN/AKT signaling pathway. Therefore, AQP8 may serve as a potential therapeutic target in gliomas.
Article
Environmental Sciences
Huijie Chen, Yue Zhang, Mengmeng Zou, Xiaowei Sun, Xiaodan Huang, Shiwen Xu
Summary: By targeting PTEN, naringenin can inhibit oxidative stress caused by dibutyl phthalate and activate the PI3K/AKT signaling pathway, thereby inhibiting cell apoptosis caused by the mitochondrial pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Chunhui Nie, Bei Wang, Baoquan Wang, Ning Lv, Rui Yu, Enfan Zhang
Summary: The study revealed that protopine inhibits liver carcinoma cell viability by triggering apoptosis and suppressing the PI3K/Akt signaling pathway. In vivo experiments showed that protopine effectively repressed tumor growth without noticeable toxicity, indicating its potential as a therapeutic agent for liver carcinoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang, Yibo Mei, Jinlai Zhou, Minghai Ma, Jianbin Ma, Yue Chong, Xinyang Wang, Peng Guo, Dalin He, Jin Zeng
Summary: The study found that the novel 450-nm laser-mediated DVDMS-based photodynamic therapy (PDT) can inhibit and induce apoptosis in gastric cancer cells by producing excessive reactive oxygen species (ROS). Additionally, PDT also promoted apoptosis in gastric cancer cells through the autophagy pathway. Furthermore, the study identified the involvement of the ROS/PI3K/Akt/mTOR pathway in the regulation of PDT-induced autophagy.
Article
Cell Biology
Yulin Zhao, Aimin Li
Summary: Emerging studies have shown that miR-19b-3p is downregulated in IVDD patients and can suppress HNPC apoptosis and promote proliferation by regulating the PTEN/PI3K/Akt/mTOR pathway.
Article
Fisheries
Xuan Lihui, Qiu Xiaojie, Yu Hao, Chu Jialiang, Guo Jinming, Chang Ying
Summary: The organophosphorus pesticide profenofos (PFF) induces genotoxicity in fish hepatocytes, while the sesquiterpenoid Albicanol can reduce oxidative stress and the activation of the p53 signaling pathway in this process.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Chemistry, Analytical
Lihui Xuan, Liang Xiao, Ruixue Huang
Summary: This review provides a comprehensive overview of the genotoxic effects of microplastics on human health and the current research trends in the field. It emphasizes the need for scientists to further contribute through extensive academic investigation, global cooperation, and the development of novel control methods.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
Article
Environmental Sciences
Lihui Xuan, Jinming Guo, Dexin Xia, Lu Li, Daining Wang, Ying Chang
Summary: This study found that profenofos (PFF) as an environmental pollutant can harm human health through the food chain. Albicanol, a sesquiterpene compound, has been shown to antagonize the toxicity caused by PFF exposure. However, the mechanism of PFF toxicity and the role of Albicanol in regulating immune function, apoptosis, and necroptosis have not been reported. The study revealed that PFF exposure led to mitochondrial damage, increased expression of innate immunity-related factors, and activated TNF/NF-kappa B pathway, while Albicanol countered these effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)