Inhibition ofNeisseria gonorrhoeaeType II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914

Bacillus anthracis GrlAV96ATopoisomerase IV, a Quinolone Resistance Mutation That Does Not Affect the Water-Metal Ion Bridge

(2014) Katie J. Aldred et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel High-Throughput Cell-Based Assay Aimed at Identifying Inhibitors of DNA Metabolism in Bacteria

(2014) Jun Fan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HighIn VitroActivity of the Novel Spiropyrimidinetrione AZD0914, a DNA Gyrase Inhibitor, against Multidrug-Resistant Neisseria gonorrhoeae Isolates Suggests a New Effective Option for Oral Treatment of Gonorrhea

(2014) Susanne Jacobsson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroAntibacterial Activity of AZD0914, a New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious Gram-Negative, and Atypical Bacteria

(2014) Michael D. Huband et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of the Novel DNA Gyrase Inhibitor AZD0914: Low Resistance Potential and Lack of Cross-Resistance in Neisseria gonorrhoeae

(2014) Richard A. Alm et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Quinolone Action and Resistance

(2014) Katie J. Aldred et al.   BIOCHEMISTRY

Characterization of Neisseria gonorrhoeaeisolates detected in Switzerland (1998–2012): emergence of multidrug-resistant clones less susceptible to cephalosporins

(2014) Andrea Endimiani et al.   BMC INFECTIOUS DISEASES

Novel compounds targeting bacterial DNA topoisomerase/DNA gyrase

(2014) David E Ehmann et al.   CURRENT OPINION IN PHARMACOLOGY

Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization

(2014) Gregory S. Basarab et al.   JOURNAL OF MEDICINAL CHEMISTRY

Overcoming Target-Mediated Quinolone Resistance in Topoisomerase IV by Introducing Metal-Ion-Independent Drug–Enzyme Interactions

(2013) Katie J. Aldred et al.   ACS Chemical Biology

A high-throughput fluorescence anisotropy-based assay for human topoisomerase II β-catalyzed ATP-dependent supercoiled DNA relaxation

(2013) Adam B. Shapiro et al.   ANALYTICAL BIOCHEMISTRY

A high-throughput-compatible, fluorescence anisotropy-based assay for ATP-dependent supercoiled DNA relaxation by human topoisomerase IIα

(2013) Adam B. Shapiro   BIOCHEMICAL PHARMACOLOGY

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

(2013) Katie J. Aldred et al.   NUCLEIC ACIDS RESEARCH

Isolation and Quantitation of Topoisomerase Complexes Accumulated on Escherichia coli Chromosomal DNA

(2012) Sandra Aedo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inducible SOS Response System of DNA Repair and Mutagenesis in Escherichia coli

(2012) Celina Janion   International Journal of Biological Sciences

Drug Interactions with Bacillus anthracis Topoisomerase IV: Biochemical Basis for Quinolone Action and Resistance

(2011) Katie J. Aldred et al.   BIOCHEMISTRY

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

(2010) Alexandre Wohlkonig et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Target specificity of the new fluoroquinolone besifloxacin in Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli

(2009) E. Cambau et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

(2009) Ivan Laponogov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY