Article
Cell Biology
Sreepadaarchana Munjuluri, Dru A. Wilkerson, Gagandeep Sooch, Xingjuan Chen, Fletcher A. White, Alexander G. Obukhov
Summary: This review discusses the effects of capsaicin on vascular function, indicating that excessive consumption of capsaicin may lead to vasoconstriction and myocardial infarction, while emphasizing the role of inflammation in sensitizing the vascular channels to capsaicin activation.
Article
Neurosciences
Al Mahdy Hamieh, David Babin, Evelyne Sable, Anne Marie Hernier, Vincent Castagne
Summary: The study aimed to further characterize behavioral changes in a neonatal PCP and post-weaning social isolation dual-hit rat model and evaluate the effects of chronic clozapine treatment on signs related to schizophrenia. The results showed persistent deficits in locomotor activity and social recognition in the PCP-SI rats, which were ameliorated by chronic clozapine treatment, confirming the predictive validity of this animal model.
PSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Tina Blazevic, Cosmin I. Ciotu, Markus Gold-Binder, Elke H. Heiss, Michael J. M. Fischer, Verena M. Dirsch
Summary: Capsaicin, an active compound of chili peppers, can inhibit platelet-derived growth factor-induced proliferation in primary rat vascular smooth muscle cells (VSMCs), possibly through a role of TRPV1. However, commercially available antibodies were ineffective in detecting TRPV1 expression. Moreover, TRPV1 agonists did not increase intracellular calcium levels in VSMCs. RT-qPCR results showed low TRPV1 expression in VSMCs, suggesting the absence of canonical TRPV1 channel activity.
Article
Pharmacology & Pharmacy
Chenfei Wang, Wei Huang, Jia Lu, Hongzhuan Chen, Zhihua Yu
Summary: Autophagy plays a crucial role in regulating the ageing process and neurodegeneration. Dysfunction of autophagy is implicated in Alzheimer's disease pathogenesis. The activation of TRPV1 using capsaicin induces autophagy, which could potentially be a therapeutic target for Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jia Lu, Wei Zhou, Fangfang Dou, Chenfei Wang, Zhihua Yu
Summary: Microglia energy metabolism is suppressed during chronic A beta-tolerant processes, but pharmacological activation of TRPV1 can rescue microglial dysfunction and restore immune responses, leading to reduced amyloid pathology and reversed memory deficits in AD mice. This study suggests that TRPV1 is an important target for regulating metabolic reprogramming in microglial functions for AD treatment.
Article
Psychiatry
Yangsik Kim, Young Woo Noh, Kyungdeok Kim, Eunjoon Kim
Summary: The lack of IRSp53 results in decreased PPI, and the hyperactive ACC-MDT pathway suppresses PPI.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Yangsik Kim, Esther Yang, Hyun Kim
Summary: The study found that deletion of IRSp53 in mice leads to a decrease in prepulse inhibition (PPI), indicating that dysfunction of various modulatory neurons may result in PPI impairment. This suggests that PPI could be broadly affected by changes in various types of modulatory neurons.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Hisayoshi Kubota, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Masaya Hasegawa, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri
Summary: Phencyclidine (PCP) causes mental symptoms similar to schizophrenia by inhibiting the glutamatergic system. Deficiency of kynurenine 3-monooxygenase (KMO) may be associated with exacerbation of PCP-induced symptoms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Food Science & Technology
Qunran Xiang, Weiling Guo, Xin Tang, Shumao Cui, Feng Zhang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Bingyong Mao, Wei Chen
Summary: Long-term and high levels of capsaicin ingestion may cause gastrointestinal discomfort and affect gastrointestinal digestion, with a more pronounced impact on specific gastrointestinal disorders. Capsaicin can regulate visceral pain and immune response through mechanisms involving the TRPV1 receptor and neuropeptides, impacting oxidative stress and tissue permeability of the gastrointestinal tract. Probiotics have the potential to alleviate capsaicin-induced gastrointestinal discomfort based on their effects on gastrointestinal disorders and their correlation with TRPV1.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kaihua Zhang, David Julius, Yifan Cheng
Summary: This study utilized cryo-EM to visualize conformational transitions of TRPV1, revealing the dynamic transitions of its selectivity filter in response to algogenic agents. The findings also demonstrate a general framework for understanding how TRP channels function as polymodal signal integrators.
Article
Food Science & Technology
Qunran Xiang, Xin Tang, Shumao Cui, Qiuxiang Zhang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Bingyong Mao, Wei Chen
Summary: This study investigated the effects of different doses of capsaicin on gastrointestinal health in mice. The results showed that high doses (60 and 80 mg/kg) of capsaicin caused intestinal inflammation and increased levels of serum neuropeptides. The levels of short-chain fatty acids in the cecum also significantly increased. These changes may be related to alterations in gut microbiota.
Review
Biochemistry & Molecular Biology
Nuray Erin, Arpad Szallasi
Summary: Both sensory neurons and immune cells express TRPV1, which can induce neurogenic inflammation and modify tumor growth and metastasis. TRPV1 is also found in various immune cells, and the effects of TRPV1 agonists and antagonists depend on the cell type(s) activated and/or inhibited. A comprehensive understanding of TRPV1 activity on immune cells and nerve endings is necessary to predict the outcome of therapies targeting TRPV1 channels. This review focuses on the neuro-immune modulation of cancer growth and metastasis caused by TRPV1 activation and discusses the potential use of TRPV1 modulators in cancer therapy.
Article
Biochemistry & Molecular Biology
Lei Liu, Yuhua Tian
Summary: The presence of TRPV1 ion channels in brain regions other than the hypothalamus has been debated. By injecting capsaicin directly into the lateral ventricle of rats and recording EEGs, we found that capsaicin perturbed brain electrical activity during sleep, suggesting TRPV1 expression in specific brain regions dominant during this stage.
Article
Chemistry, Multidisciplinary
Jing-xian Sun, Ke-ying Zhu, Yu-meng Wang, Dan-jie Wang, Mi-zhen Zhang, Heela Sarlus, Irene Benito-Cuesta, Xiao-qiang Zhao, Zao-feng Zou, Qing-yang Zhong, Yi Feng, Shuai Wu, Yan-qing Wang, Robert A. Harris, Jun Wang
Summary: The role of TRPV1 in demyelinating diseases has been investigated, and it has been found to be an important regulator in the context of demyelination. TRPV1 deficiency exacerbates motor dysfunction and demyelination, while TRPV1 agonist CAP improves behavioral performance and facilitates remyelination. The activation of TRPV1 enhances microglial function and promotes myelin debris clearance.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Psychiatry
Shabeesh Balan, Tetsuo Ohnishi, Akiko Watanabe, Hisako Ohba, Yoshimi Iwayama, Manabu Toyoshima, Tomonori Hara, Yasuko Hisano, Yuki Miyasaka, Tomoko Toyota, Chie Shimamoto-Mitsuyama, Motoko Maekawa, Shusuke Numata, Tetsuro Ohmori, Tomomi Shimogori, Yoshiaki Kikkawa, Takeshi Hayashi, Takeo Yoshikawa
Summary: The study reanalyzed previously identified quantitative trait loci for prepulse inhibition (PPI) and identified a PPI-regulating Cdh23 variant, as well as a possible contribution of CDH23 to schizophrenia susceptibility.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
David W. Greening, Michael Notaras, Maoshan Chen, Rong Xu, Joel D. Smith, Lesley Cheng, Richard J. Simpson, Andrew F. Hill, Maarten van den Buuse
Summary: Studies have shown that chronic Meth abuse can lead to psychotic episodes resembling schizophrenia, with Brain-derived neurotrophic factor (BDNF) playing a crucial role in this process. Research on transgenic mice revealed that BDNF genetic variation significantly influences the long-term brain changes induced by Meth, indicating that drug-induced psychosis may be modulated at the molecular level by a single genetic locus.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Laura K. Milton, Paul N. Mirabella, Erika Greaves, David C. Spanswick, Maarten van den Buuse, Brian J. Oldfield, Claire J. Foldi
Summary: This study investigated the neurobiological link between pathological weight loss and cognitive flexibility, showing that modulation of activity within the mPFC-AcbSh pathway can prevent weight loss in ABA and improve cognitive flexibility. This finding highlights the relationship between disrupted prefrontal function and cognitive rigidity in AN patients, providing insight into the executive control of feeding behavior and potential new treatment strategies.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Immunology
Jay P. Nakamura, Brendan Gillespie, Andrew Gibbons, Emily J. Jaehne, Xin Du, Aaron Chan, Anna Schroeder, Maarten van den Buuse, Suresh Sundram, Rachel A. Hill
Summary: Research using a mouse MIA model has shown that targeting a specific developmental window of parvalbumin interneurons can enhance spatial working memory performance, independent of anxiety or novelty seeking behavior.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Maarten van den Buuse, Paul Halley, Gerard F. Hoyne
Summary: The hypomorphic allele of hnRNPLL gene affects immune system and brain function, and the mice model for psychiatric illnesses exhibit behaviors related to depression, impaired spatial memory, and reduced avoidance learning.
NEUROSCIENCE LETTERS
(2021)
Article
Behavioral Sciences
Natasha L. Hogan, Emily J. Jaehne, Sharon Bak, Elvan Djouma, Maarten van den Buuse
Summary: Impulsivity may be a potential predictor of addiction risk, while the BDNFVal66Met polymorphism may sex-specifically alter aspects of impulsive behavior and addiction propensity.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Stephanie C. Tran, Emily J. Jaehne, Laura E. Dye, Joanne Wong, Jana S. Bakas, Jemma G. Gasperoni, Matthew W. Hale, Maarten van den Buuse, Sebastian Dworkin, Sylvia V. H. Grommen, Bert De Groef
Summary: Plag1 gene deficiency in mice has mild effects on behavior, with no significant differences in circadian activity levels, locomotion, object recognition, spatial memory, or sociability compared to wild-type mice. However, tests suggest that Plag1 KO mice may have a hearing impairment, indicating a potential role in auditory processes.
Article
Neurosciences
Michelle Corrone, Aleshia Nanev, Isabella Amato, Rowena Bicknell, Daniel William Taylor Wundersitz, Maarten van den Buuse, Bradley James Wright
Summary: This study investigated the impact of the val66met gene on decision making and attention, revealing that carriers of the Val/met genotype performed better in these aspects. They also exhibited higher levels of perceived chronic stress and increased sympathetic activity.
Article
Behavioral Sciences
Emily J. Jaehne, Elaine Mei San Chong, Alyssa Sbisa, Brendan Gillespie, Rachel Hill, Andrea Gogos, Maarten van den Buuse
Summary: The study suggests that in offspring of maternal immune activation (MIA), the TrkB agonist 7,8-DHF can reverse PPI deficits caused by dopaminergic stimulation, possibly through the increased expression of BDNF in the frontal cortex. Targeting BDNF signaling may have therapeutic potential for treating certain symptoms of schizophrenia.
BEHAVIOURAL PHARMACOLOGY
(2021)
Article
Psychiatry
Andrea Gogos, Jeehae Sun, Madhara Udawela, Andrew Gibbons, Maarten van den Buuse, Elizabeth Scarr, Brian Dean
Summary: The study found alterations in RAPGEF1 expression in the BA 8 of subjects with schizophrenia, but no differences in BA 8 and 44. Suicide completers had higher RAPGEF1 levels compared to non-suicide schizophrenia subjects in BA 8. Further investigation into the function of RAPGEF1 may provide insights into the pathophysiology of schizophrenia.
PSYCHIATRY RESEARCH
(2021)
Article
Neurosciences
Mauricio Sepulveda, Elizabeth E. Manning, Andrea Gogos, Matthew Hale, Maarten van den Buuse
Summary: This study evaluated the long-term effects of chronic METH treatment on the serotonin system in the brain using various techniques. The results indicated that METH treatment can lead to long-term or selective effects on brain serotonin systems. METH pretreatment may affect 5-HT1A receptor binding and reduce DRN cell counts selectively in BDNF HET mice.
Article
Biology
Carla L. Pietrucci, Laura K. Milton, Erika Greaves, Aneta Stefanidis, Maarten van den Buuse, Brian J. Oldfield, Claire J. Foldi
Summary: Genetic animal models are a valuable tool for understanding human pathologies, with the choice of model being crucial for uncovering specific effects. Contrary to previous findings in mice, the BDNF Val66Met polymorphism does not appear to influence susceptibility to weight loss or energy balance in a rat model of anorexia nervosa. These discrepancies highlight the importance of considering species-specific differences in research on animal models of human diseases.
Article
Developmental Biology
Emily J. Jaehne, Jessica N. Kent, Nikki Lam, Lina Schonfeld, Jereme G. Spiers, Veronica Begni, Federico De Rosa, Marco A. Riva, Maarten van den Buuse
Summary: Exercise has been shown to be beneficial in reducing symptoms of affective disorders and increasing BDNF expression. This study found that rats that had access to running wheels during adolescence exhibited higher levels of anxiety and depression-like behaviors in adulthood, regardless of their BDNF Val66Met genotype.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Neurosciences
Matthew R. Hudson, Joshua Foreman, Gil Rind, Elizabeth E. Manning, Nigel C. Jones, Maarten van den Buuse
Summary: Chronic METH treatment does not affect the regulation of high-frequency neuronal oscillations in the brain, despite causing behavioral sensitization.
Article
Biology
Emily J. Jaehne, Elizabeth McInerney, Ronan Sharma, Shannyn G. Genders, Elvan Djouma, Maarten van den Buuse
Summary: The Val66Met gene variant reduces the release of BDNF in the brain, leading to decreased preference and seeking for alcohol. Using a rat model, researchers found that rats with the Met/Met genotype had lower motivation to seek alcohol and a decreased propensity to relapse. This suggests a possible protective effect of the Met/Met genotype against alcohol use disorder, particularly in females.
Article
Biochemistry & Molecular Biology
Samuel Hogarth, Emily J. Jaehne, Xiangjun Xu, Quenten Schwarz, Maarten van den Buuse
Summary: The aim of this study was to investigate the role of BDNF and dopamine D3 receptors in the effects of chronic methamphetamine on prepulse inhibition (PPI), an endophenotype of psychosis. The results showed that chronic methamphetamine disrupted PPI regulation in male mice with BDNF haploinsufficiency, regardless of D3 receptor knockout. However, there were no effects of BDNF heterozygosity or D3 knockout on PPI regulation in female mice. These findings suggest a significant involvement of BDNF in the long-term effects of methamphetamine on PPI, particularly in male mice.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
