The effects of a dual orexin receptor antagonist on fear extinction memory and sleep in mice: Implications for exposure therapy

Efficacy and tolerability of pharmacological treatments for insomnia in adults: A systematic review and network meta-analysis

(2023) Jing-Li Yue et al.   SLEEP MEDICINE REVIEWS

Optimizing first line treatments for adults with OCD

(2022) V. Nezgovorova et al.   COMPREHENSIVE PSYCHIATRY

Alteration of fear behaviors in sleep-deprived adolescent rats: increased fear expression and delayed fear extinction

(2021) Taesub Jung et al.   Animal Cells and Systems

Manipulation of rapid eye movement sleep via orexin and GABAA receptor modulators differentially affects fear extinction in mice: effect of stable versus disrupted circadian rhythm

(2021) Jacob W Clark et al.   SLEEP

Blocking the orexin system following therapeutic exposure promoted between session habituation, but not PTSD symptom reduction

(2021) Ihori Kobayashi et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Investigating the role of the amygdala orexin receptor 1 in memory acquisition and extinction in a rat model of PTSD

(2020) Sudabeh Salehabadi et al.   BEHAVIOURAL BRAIN RESEARCH

Evolution of Orexin Neuropeptide System: Structure and Function

(2020) Shingo Soya et al.   Frontiers in Neuroscience

Differential behavioral, stress, and sleep responses in mice with different delays of fear extinction

(2019) Mayumi Machida et al.   SLEEP

Therapeutic strategies for social anxiety disorder: where are we now?

(2019) Antoine Pelissolo et al.   Expert Review of Neurotherapeutics

REM deprivation but not sleep fragmentation produces a sex-specific impairment in extinction

(2018) Amy Silvestri Hunter   PHYSIOLOGY & BEHAVIOR

Effects of post-exposure naps on exposure therapy for social anxiety

(2018) Edward F. Pace-Schott et al.   PSYCHIATRY RESEARCH

Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture

(2018) Yuki C. Saito et al.   Frontiers in Neuroscience

Brain prolactin is involved in stress-induced REM sleep rebound

(2017) Ricardo Borges Machado et al.   HORMONES AND BEHAVIOR

Facilitation of Contextual Fear Extinction by Orexin-1 Receptor Antagonism Is Associated with the Activation of Specific Amygdala Cell Subpopulations

(2017) África Flores et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The Efficacy of Exposure Therapy for Anxiety-Related Disorders and Its Underlying Mechanisms: The Case of OCD and PTSD

(2016) Edna B. Foa et al.   Annual Review of Clinical Psychology

REM Sleep Is Causal to Successful Consolidation of Dangerous and Safety Stimuli and Reduces Return of Fear after Extinction

(2016) M. M. Menz et al.   JOURNAL OF NEUROSCIENCE

Sleep supports cued fear extinction memory consolidation independent of circadian phase

(2016) Irene Melo et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Effects of suvorexant on sleep architecture and power spectral profile in patients with insomnia: analysis of pooled phase 3 data

(2016) Ellen Snyder et al.   SLEEP MEDICINE

REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP

(2015) Pascal Ravassard et al.   CEREBRAL CORTEX

The Hypocretin/Orexin System Mediates the Extinction of Fear Memories

(2014) África Flores et al.   NEUROPSYCHOPHARMACOLOGY

Ventromedial prefrontal cortex activity and rapid eye movement sleep are associated with subsequent fear expression in human subjects

(2014) V. I. Spoormaker et al.   EXPERIMENTAL BRAIN RESEARCH

Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice

(2014) Keishi Etori et al.   Frontiers in Neuroscience

Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia

(2013) Claudia Betschart et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fear Extinction Memory Consolidation Requires Potentiation of Pontine-Wave Activity during REM Sleep

(2013) S. Datta et al.   JOURNAL OF NEUROSCIENCE

Distinct effects of IPSU and suvorexant on mouse sleep architecture

(2013) Daniel Hoyer et al.   Frontiers in Neuroscience

Differential Roles of Orexin Receptors in the Regulation of Sleep/Wakefulness

(2013) Michihiro Mieda et al.   Frontiers in Endocrinology

REM Sleep Rebound as an Adaptive Response to Stressful Situations

(2012) Deborah Suchecki et al.   Frontiers in Neurology

Effects of rapid eye movement sleep deprivation on fear extinction recall and prediction error signaling

(2011) Victor I. Spoormaker et al.   HUMAN BRAIN MAPPING

Acute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice

(2011) T. Tsunematsu et al.   JOURNAL OF NEUROSCIENCE

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

(2010) Christopher D. Cox et al.   JOURNAL OF MEDICINAL CHEMISTRY

Circadian rhythms of basal orexin levels in the hypothalamus are not influenced by an impaired corticotropin-releasing hormone receptor type 1 system

(2009) Thomas Fenzl et al.   BEHAVIOURAL BRAIN RESEARCH

Altered Sleep Homeostasis after Restraint Stress in 5-HTT Knock-Out Male Mice: A Role for Hypocretins

(2009) A. Rachalski et al.   JOURNAL OF NEUROSCIENCE

Circadian and dark-pulse activation of orexin/hypocretin neurons

(2008) Oliver J Marston et al.   Molecular Brain

Stress-induced changes in sleep in rodents: Models and mechanisms

(2007) Aaron C. Pawlyk et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS