Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition, and Implication of CDH23 in Schizophrenia

c.753A>G genome editing of a Cdh23 allele delays age-related hearing loss and degeneration of cochlear hair cells in C57BL/6J mice

(2020) Shumpei P. Yasuda et al.   HEARING RESEARCH

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Emerging phenotyping strategies will advance our understanding of psychiatric genetics

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Evidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia

(2020) Kayoko Esaki et al.   SCHIZOPHRENIA BULLETIN

Prefecture-level population structure of the Japanese based on SNP genotypes of 11,069 individuals

(2020) Yusuke Watanabe et al.   JOURNAL OF HUMAN GENETICS

Evaluation of the role of fatty acid-binding protein 7 in controlling schizophrenia-relevant phenotypes using newly established knockout mice

(2019) Chie Shimamoto-Mitsuyama et al.   SCHIZOPHRENIA RESEARCH

Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis

(2019) Stephan C. Collins et al.   Nature Communications

Investigation of betaine as a novel psychotherapeutic for schizophrenia

(2019) Tetsuo Ohnishi et al.   EBioMedicine

Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology

(2019) Masayuki Ide et al.   EMBO Molecular Medicine

Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study

(2019) Tiffany A. Greenwood et al.   JAMA Psychiatry

Psychiatric genetics and the structure of psychopathology

(2018) Jordan W. Smoller et al.   MOLECULAR PSYCHIATRY

Digital gene atlas of neonate common marmoset brain

(2018) Tomomi Shimogori et al.   NEUROSCIENCE RESEARCH

Sensorimotor gating deficits in schizophrenia: Advancing our understanding of the phenotype, its neural circuitry and genetic substrates

(2018) Neal R. Swerdlow et al.   SCHIZOPHRENIA RESEARCH

Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction

(2017) Baptiste Libé-Philippot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficient prepulse inhibition in schizophrenia in a multi-site cohort: Internal replication and extension

(2017) Neal R. Swerdlow et al.   SCHIZOPHRENIA RESEARCH

Beyond Cell–Cell Adhesion: Sensational Cadherins for Hearing and Balance

(2017) Avinash Jaiganesh et al.   Cold Spring Harbor Perspectives in Biology

Genetic tests in major psychiatric disorders—integrating molecular medicine with clinical psychiatry—why is it so difficult?

(2017) U Demkow et al.   Translational Psychiatry

Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains

(2017) Kenneth R. Johnson et al.   Scientific Reports

The Relationship of Common Risk Variants and Polygenic Risk for Schizophrenia to Sensorimotor Gating

(2016) Panos Roussos et al.   BIOLOGICAL PSYCHIATRY

Heterozygous mutation ofUsh1g/Sansin mice causes early-onset progressive hearing loss, which is recovered by reconstituting the strain-specific mutation inCdh23

(2016) Yuki Miyasaka et al.   HUMAN MOLECULAR GENETICS

Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next

(2016) Neal R Swerdlow et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair

(2016) Joffrey Mianné et al.   Genome Medicine

Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins

(2016) Qi Zhang et al.   Molecular Brain

Analysis of induced pluripotent stem cells carrying 22q11.2 deletion

(2016) M Toyoshima et al.   Translational Psychiatry

Genomic resources for wild populations of the house mouse, Mus musculus and its close relative Mus spretus

(2016) Bettina Harr et al.   Scientific Data

Factor structure and heritability of endophenotypes in schizophrenia: Findings from the Consortium on the Genetics of Schizophrenia (COGS-1)

(2015) Larry J. Seidman et al.   SCHIZOPHRENIA RESEARCH

MIPgen: optimized modeling and design of molecular inversion probes for targeted resequencing

(2014) Evan A. Boyle et al.   BIOINFORMATICS

Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies

(2014) Chie Shimamoto et al.   HUMAN MOLECULAR GENETICS

Rat subthalamic nucleus and zona incerta share extensively overlapped representations of cortical functional territories

(2014) Takako Kita et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Deficient prepulse inhibition in schizophrenia detected by the multi-site COGS

(2014) Neal R. Swerdlow et al.   SCHIZOPHRENIA RESEARCH

Sorting out a promiscuous superfamily: towards cadherin connectomics

(2014) Marcos Sotomayor et al.   TRENDS IN CELL BIOLOGY

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Compound Heterozygosity of the Functionally Null Cdh23v-ngt and Hypomorphic Cdh23ahl Alleles Leads to Early-onset Progressive Hearing Loss in Mice

(2013) Yuki Miyasaka et al.   EXPERIMENTAL ANIMALS

The anatomy of the caudal zona incerta in rodents and primates

(2013) Charles Watson et al.   JOURNAL OF ANATOMY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Deep brain stimulation of the subthalamic nucleus in the 6-hydroxydopamine rat model of Parkinson's disease: Effects on sensorimotor gating

(2012) Christoph Lindemann et al.   BEHAVIOURAL BRAIN RESEARCH

Comparative Anatomy of Marmoset and Mouse Cortex from Genomic Expression

(2012) H. Mashiko et al.   JOURNAL OF NEUROSCIENCE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Cadherins in Brain Morphogenesis and Wiring

(2012) Shinji Hirano et al.   PHYSIOLOGICAL REVIEWS

Subthalamic nucleus stimulation for Parkinson disease with severe medication-induced hallucinations or delusions

(2011) Atsushi Umemura et al.   JOURNAL OF NEUROSURGERY

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

(2010) Thomas Insel et al.   AMERICAN JOURNAL OF PSYCHIATRY

Japanese Population Structure, Based on SNP Genotypes from 7003 Individuals Compared to Other Ethnic Groups: Effects on Population-Based Association Studies

(2008) Yumi Yamaguchi-Kabata et al.   AMERICAN JOURNAL OF HUMAN GENETICS