Article
Neurosciences
Hojjatollah Alaei, Mozhgan Ghobadi Pour
Summary: The VTA plays a key role in processing psychological dependency, opioid reinforcement, and opiate-related associative reward. The study found that 150 mu A VTA electrical stimulation could suppress 5 mg/kg morphine-induced CPP. Additionally, intra-VTA administration of Lidocaine significantly decreased the acquisition phase of 5 mg/kg morphine-induced CPP, which was reversed in the reinstatement test. These findings are important for understanding mesolimbic nervous system connections and may lead to new ways to reduce the rewarding effects of morphine.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Lisha Deng, Zheng Chu, Baijia Li, Peng Liu, Gang Lei, Liu Yang, Leile Zhang, Shaofu Li, Yiming Wang, Yonghui Dang
Summary: The study found that injection of BDNF-adeno-associated viral vector in the VTA attenuated morphine-induced CPP with synergistic changes in BDNF/TrkB/CREB concentrations in the VTA and NAc in the CPP acquisition and recurrence phases, but the attenuation was lower in the extinction phase with different changes in molecules downstream of BDNF.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Xuhong Li, Yuqian Zheng, Xiaoxuan Zhao, Ruisi Cui, Xinwang Li
Summary: Opioid use disorder results from functional defects in the brain reward loop. RMTg M3 receptors and dopamine D1 receptors play important roles in regulating opioid reward. Activation of RMTg M3 receptors can counteract the rewarding effects of morphine, and dopamine activity in VTA and NAcS may be involved.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
J. Daniel Obray, Christina A. Small, Emily K. Baldwin, Eun Young Jang, Jin Gyeom Lee, Chae Ha Yang, Jordan T. Yorgason, Scott C. Steffensen
Summary: This study found that peripherally administered dopamine can enhance dopamine levels in the nucleus accumbens and modulate related behaviors. Dopamine subtype-2 receptors are involved in this process and can influence dopamine neuron activity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Grazyna Jerzemowska, Karolina Plucinska, Aleksandra Piwka, Magdalena Podlacha, Jolanta Orzel-Gryglewska
Summary: In this study, the researchers investigated the role of opioid receptors (OR) in the pedunculopontine tegmental nucleus (PPN) in regulating motivated behaviors. They found that activation and blocking of OR in the PPN affected behavioral and neuronal activity, modulating the reward system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Zachary A. Grieb, Joseph S. Lonstein
Summary: The interaction between oxytocin and central dopamine and serotonin systems is crucial for behavioral adaptations during the postpartum period. Oxytocin-dopamine interaction regulates maternal motivation and active caregiving behaviors, while oxytocin-serotonin interaction influences other aspects such as nursing, aggression, anxiety-like behavior, and stress coping strategy.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Darrell Eacret, Crystal Lemchi, Jasmine I. Caulfield, Sonia A. Cavigelli, Sigrid C. Veasey, Julie A. Blendy
Summary: This study investigates the influence of chronic short sleep on opioid reward using a mouse model. The results show that recovery sleep after chronic sleep disruption lessens voluntary opioid intake, but does not affect conditioned reward associated with morphine.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychology, Biological
Chayaporn Reakkamnuan, Dania Cheaha, Nifareeda Samerphob, Nusaib Sa-ih, Ekkasit Kumarnsit
Summary: This study aimed to investigate the neural adaptive mechanisms associated with the formation of morphine conditioned place preference. The findings suggested that NAc LFP signaling and neural connectivities between the NAc and HC may play a role in morphine CPP.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Clinical Neurology
Claudia Calpe-Lopez, Ani Gasparyan, Francisco Navarrete, Jorge Manzanares, Jose Minarro, Maria A. Aguilar
Summary: The study found that CBD may reduce reinstatement of seeking cocaine in mice, and CBD itself does not induce reinstatement but can block the reinstating effects of cocaine priming and social defeat. Furthermore, cocaine priming increased the gene expression of DAT in the ventral tegmental area, which was completely reversed by CBD.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Zahra Mansouri Arani, Nasrin Heidariyeh, Gholamreza Ghavipanjeh, Majid Lotfinia, Hamid Reza Banafshe
Summary: The present study aimed to investigate the effect of risperidone, an atypical antipsychotic drug, on morphine-induced conditioned place preference (CPP) and D2 dopamine receptor gene expression in the rat hippocampus. The results showed that a low dose of risperidone (1 mg/kg) reversed morphine-induced CPP and decreased the expression of D2 dopamine receptor in the hippocampus. Therefore, risperidone may be considered a potential adjunct therapy for morphine dependence.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
E. Liu, Kunkun Pang, Min Liu, Xu Tan, Zhaofang Hang, Shouhong Mu, Weikai Han, Qingwei Yue, Stefano Comai, Jinhao Sun
Summary: The brain circuit between the ventral tegmental area (VTA) and nucleus accumbens lateral shell (NAcLat) plays a crucial role in methamphetamine addiction. By isolating and profiling dopamine (DA) neurons in the VTA-NAcLat circuit of MA-treated mice, researchers discovered that downregulation of KCNQ genes, encoding Kv7 channel proteins, was associated with addiction. Activation of Kv7.2/3 and Kv7.4 channels attenuated MA-induced addiction behaviors by reducing neuronal excitability and dopamine release.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Xiaolin Kou, Jiayun Xian, Zhenquan Huang, Yan Tao, Yuhui Lin, Cheng Qin, Haiyin Wu, Lei Chang, Chunxia Luo, Dongya Zhu
Summary: Drug abuse is a significant societal challenge with high relapse rates. Environmental cues play a crucial role in drug abuse preference memory. Extinction therapy has been developed to inhibit the motivational effects of drug cues and prevent the reinstatement of morphine abuse. However, this therapy alone only results in unstable inhibitory memory.
Article
Plant Sciences
Guiyun Wu, Xiaoying Xu, Fang Ye, Haihua Shu
Summary: The study found that processed Aconiti tuber (PAT) shortens the extinction of morphine-induced CPP when administered before CPP formation, but extends the extinction when administered after CPP acquisition. PAT has no effect on the reinstatement of CPP. The dynorphin concentration in the nucleus accumbens increases with PAT administration.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Xue-Fei Hou, Ya-Bo Zhao, Yue-Xiong Yang, Jing Zhu, Li-Su Zhu, Lin Xu, Qi-Xin Zhou
Summary: In this study, a simple and effective experimental model was designed to investigate the generalization memory of morphine reward. By replacing the conditioning CPP box, it was found that mice still showed a clear preference for generalized information. The establishment of this study provides a new tool for studying generalization memory in substance use disorders.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Laszlo Peczely, Tamas Ollmann, Kristof Laszlo, Laszlo Lenard, Anthony A. Grace
Summary: Quinpirole dose dependently regulates VTA dopaminergic activity and influences motivation and motor behavior in rats at the level of the ventral pallidum.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Farzaneh Nazari-Serenjeh, Ronak Azizbeigi, Mina Rashvand, Somaye Mesgar, Haleh Amirteymori, Abbas Haghparast
Summary: Due to the relapsing properties of psychostimulants like methamphetamine, there is currently no established pharmacotherapy for methamphetamine addiction. The orexinergic system shows promise as a target for treating psychostimulant use disorders and relapse. However, no previous research has investigated the role of orexin receptors in the dentate gyrus region of the hippocampus in the extinction and reinstatement of methamphetamine-seeking behavior. This study implanted guide cannulae into the brains of rats and conducted conditioned place preference procedures. The results indicated distinct roles for the OX1 and OX2 receptors in the dentate gyrus region, suggesting that the orexinergic system in this region could be a potential therapeutic target for psychostimulant use disorders.
Article
Biochemistry & Molecular Biology
Haleh Amirteymori, Ali Veisi, Hossein Khaleghzadeh-Ahangar, Roghayeh Mozafari, Abbas Haghparast
Summary: The aim of this study was to investigate the role of orexin-2 (OX2) receptors in the extinction and reinstatement of methamphetamine (METH)-induced conditioned place preference (CPP) in the CA1 region of the hippocampus. The results showed that blocking the OX2 receptors in the CA1 region reduced the extinction latency and suppressed the reinstatement of METH-seeking behavior. This suggests that blocking OX2 receptors in this area could be a potential therapeutic approach for treating METH use disorder.
Article
Clinical Neurology
Haleh Amirteymori, Saeideh Karimi-Haghighi, Mahboobeh Mirmohammadi, Maryam Majidinezhad, Elahe Khosrowabadi, Abbas Haghparast
Summary: This study investigates the role of the hypocretin/orexin system in treating psychostimulant addiction. The findings suggest that modulation of this system has therapeutic potential in the extinction and reinstatement of Meth-induced conditioned place preference.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Kobra Askari, Shahrbanoo Oryan, Akram Eidi, Jalal Zaringhalam, Abbas Haghparast
Summary: Exposure to stressful stimuli induces physiological and behavioral responses, affects pain perception, and alters gene expression. This study investigated the modulatory role of the ventral tegmental area (VTA) orexinergic system and ERK signaling in stress-induced analgesia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Mojdeh Fattahi, Kiarash Eskandari, Esmail Riahi, Reza Khosrowabadi, Abbas Haghparast
Summary: The study aimed to investigate the potential efficacy of deep brain stimulation (DBS) in treating methamphetamine-conditioned place preference (CPP) in rats. The findings showed that both high-frequency stimulation (HFS) and low-frequency stimulation (LFS) significantly decreased methamphetamine place preference during the conditioning period. Only HFS could accelerate the extinction of reward-context associations and reduce methamphetamine-induced reinstatement of seeking behaviors during the extinction experiment.
Article
Medicine, Research & Experimental
Kiarash Eskandari, Mojdeh Fattahi, Esmail Riahi, Reza Khosrowabadi, Abbas Haghparast
Summary: Methamphetamine (METH) addiction is a major public health issue that is difficult to cure with standard therapies. Deep Brain Stimulation (DBS) has shown promise in treating addiction by modulating neural activity. This study investigated the therapeutic effects of high- or low-frequency stimulation of the nucleus accumbens shell (NAcSh) on the extinction and reinstatement of METH-conditioned place preference (CPP). The results demonstrated that both high- and low-frequency stimulation reduced the extinction period of METH-induced CPP and prevented reinstatement of drug-seeking behavior.
Article
Endocrinology & Metabolism
Seyed Mohammadmisagh Moteshakereh, Mohammad Nikoohemmat, Danial Farmani, Elahe Khosrowabadi, Sakineh Salehi, Abbas Haghparast
Summary: Stress-induced analgesia (SIA) refers to the phenomenon where stress suppresses the sense of pain. This study aimed to investigate the role of orexin receptors in the nucleus accumbens (NAc) in the antinociceptive responses induced by forced swim stress (FSS). The results showed that microinjection of orexin receptor antagonists attenuated the FSS-induced antinociception in both phases of the formalin test, with the OX2 receptor antagonist being more potent.
Article
Endocrinology & Metabolism
Sajad Mazaheri, Morteza Zendehdel, Abbas Haghparast
Summary: The study investigated the role of orexin receptors in the ventral tegmental area (VTA) in stress-induced morphine sensitization. The results showed that concurrent exposure to stress and morphine can induce morphine sensitization, and administration of orexin receptor antagonists can block this effect. This study provides new insights into the role of orexin signaling in the VTA in the potentiation of morphine sensitization induced by stress and morphine co-administration.
Article
Behavioral Sciences
Shaghayegh Modaberi, Haleh Amirteymori, Somaye Mesgar, Kiarash Eskandari, Abbas Haghparast
Summary: This study examined the role of orexins and orexin receptors in the dentate gyrus (DG) region of the hippocampus in methamphetamine-induced conditioned place preference (CPP). The results showed that orexin receptors play a more critical role in the conditioning phase than in the expression phase.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Review
Neurosciences
Mojdeh Fattahi, Shaghayegh Modaberi, Kiarash Eskandari, Abbas Haghparast
Summary: This study examines the role of local field potentials in the context of reward and addiction. It found that drug-seeking behavior in animal models is accompanied by changes in neural oscillatory activity and connectivity among key brain areas. Future studies should focus on understanding the altered oscillatory activity patterns and developing clinical strategies, such as neuromodulation approaches, to treat addiction and prevent relapse in abstinent patients.
Article
Neurosciences
Shole Jamali, Mohsen Parto Dezfouli, AmirAli Kalbasi, Mohammad Reza Daliri, Abbas Haghparast
Summary: Despite the overlapping neural circuits, drug and natural rewards elicit different behavioral and neurochemical responses. The study found that the patterns of theta activity in the hippocampal CA1 region were different between drug and natural rewards. Comparing the activity in the CA1 region, it was observed that the maximum theta power occurred before entering the unrewarded compartment for drug rewards, while it occurred after entering the rewarded compartment for natural rewards. In conclusion, drug and natural rewards could modulate the theta dynamic in the hippocampal CA1 region differently.
Article
Behavioral Sciences
Ferdos Zamanirad, Mojdeh Fattahi, Haleh Amirteymori, Zahra Mousavi, Abbas Haghparast
Summary: Targeting the orexin system, particularly in the ventral tegmental area (VTA), has been shown to be a promising approach for treating drug addiction. Modulating the orexin system in the VTA can facilitate the extinction process of drug-related memories and prevent their relapse.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Somaye Mesgar, Kiarash Eskandari, Habib Karimian-Sani-Varjovi, Paria Salemi-Mokri-Boukani, Abbas Haghparast
Summary: The present study aimed to investigate the role of D1-like dopamine receptors (D1Rs) in SCN neural oscillations during the 24-h light-dark cycle using local field potential (LFP) recording. The results showed that the D1Rs agonist administration in the morning dramatically altered these intrinsic oscillations, decreasing delta and theta relative power, and promoting most of the higher frequency bands and LZC index. Some of these effects were reversed at night after the SKF-38393 injection.
NEUROCHEMICAL RESEARCH
(2023)
Article
Behavioral Sciences
Amir Haghparast, Mitra Yousefpour, Mina Rashvand, Laya Ghahari, Bita Rohani, Abbas Haghparast
Summary: Chemical stimulation of the LH induces analgesia by forming neural circuitries, and this study aims to detect the role of dopamine receptors within the DG in the antinociceptive responses. The results show that intra-DG administration of dopamine receptor antagonists attenuated the antinociceptive responses induced by intra-LH injection of carbachol during the orofacial formalin test. These findings suggest that chemical stimulation of the LH modulates orofacial pain, possibly through activation of the DG dopaminergic neurons.
BEHAVIOURAL PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)