Article
Cell Biology
Kerryanne Crawford, Peter L. Oliver, Thomas Agnew, Benjamin H. M. Hunn, Ivan Ahel
Summary: The study revealed that ADPr-mono-hydrolases MACROD1 and MACROD2 play important roles in behaviors associated with mitochondrial and neuropsychiatric disorders. Loss of MACROD1 led to a female-specific motor-coordination defect, while disruption of MACROD2 was linked to age-related hyperactivity and a bradykinesia-like gait.
Article
Multidisciplinary Sciences
Lien D. Nguyen, Luca G. Nolte, Winston J. T. Tan, Denise Giuvelis, Joseph Santos-Sacchi, Edward Bilsky, Barbara E. Ehrlich
Summary: NCS1 plays a modulatory role in sensory perceptions and cognition, particularly in male mice, with little impact on affective and cognitive behaviors. Loss of NCS1 in the peripheral nervous system may be of clinical interest, especially in terms of potential pharmacological targeting. Further studies on conditional KO models will help elucidate the physiological significance of NCS1.
SCIENTIFIC REPORTS
(2021)
Article
Biology
David R. Painter, Jeffrey J. Kim, Angela Renton, Jason B. Mattingley
Summary: The study demonstrates that real-time coordination between co-actors is crucial in joint actions and can enhance accuracy for the lower performing co-actor. Through neural recordings and eye tracking, researchers found that joint control affects cognitive processing across multiple stages and involves increases in both behavioral and neural coupling.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tudor Groza, Federico Lopez Gomez, Hamed Haseli Mashhadi, Violeta Munoz-Fuentes, Osman Gunes, Robert Wilson, Pilar Cacheiro, Anthony Frost, Piia Keskivali-Bond, Bora Vardal, Aaron McCoy, Tsz Kwan Cheng, Luis Santos, Sara Wells, Damian Smedley, Ann-Marie Mallon, Helen Parkinson
Summary: The International Mouse Phenotyping Consortium (IMPC) website provides a curated and analyzed platform for knockout mouse phenotyping data, which is valuable for molecular diagnosis and gene function research in rare diseases. The data and materials have been widely used in over 4,600 publications, indicating their significance.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Behavioral Sciences
Dalia N. Maron, Steven J. Bowe, Megan Spencer-Smith, Olivia J. Mellahn, Kelsey Perrykkad, Mark A. Bellgrove, Beth P. Johnson
Summary: Research has shown that individuals with ADHD exhibit oculomotor disturbances, particularly in saccade inhibition, memorizing visual target locations, and initiating antisaccades. Investigating oculomotor abnormalities in ADHD may provide insight into top-down cognitive control processes and motor control.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Pratheeban Nambyiah, Andre E. X. Brown
Summary: Exposure to anaesthetics during early development can lead to persistent behavioral variations, with higher concentrations and combinations of isoflurane and ketamine causing more features to change persistently. Morphine and dexmedetomidine do not appear to cause behavioral impairment, while lithium can rescue the neurotoxic phenotype produced by isoflurane. These findings suggest that C. elegans may be a suitable model for phenotypic screens for drugs that mitigate neurobehavioral impairment, with implications for potential high-throughput platforms in this field.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Lucia Camacho-Barcia, Ignacio Lucas, Romina Miranda-Olivos, Susana Jimenez-Murcia, Fernando Fernandez-Aranda
Summary: Individual differences in obesity are not only explained by metabolic and medical complications, but also by alterations in eating behaviour and psychological processes. The heterogeneity of psychological evidence associated with obesity has made it challenging to determine whether psycho-behavioural phenotypes can enhance treatment outcomes. This narrative review summarizes studies on psycho-behavioural phenotypes associated with obesity, identifying three psychological constructs: reward dependence, cognitive control, and mood and emotion. These findings highlight the complexity of psycho-behavioural features in obesity and emphasize the need to consider them in order to improve treatment outcomes.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Neurosciences
Veronica Brito, Enrica Montalban, Anna Sancho-Balsells, Anika Pupak, Francesca Flotta, Merce Masana, Silvia Gines, Jordi Alberch, Claire Martin, Jean-Antoine Girault, Albert Giralt
Summary: Motor skills learning is associated with cerebral and cerebellar cortices, basal ganglia nuclei, and now also found to involve the hippocampus. Transcriptional changes and reduced activity of pyramidal neurons in the CA1 region of the hippocampus are observed in mice trained in the accelerating rotarod. A subpopulation of Egr1-expressing pyramidal neurons in CA1 is activated during short-term and long-term training in the rotarod task. Manipulations of Egr1 or these neuronal ensembles affect motor learning performance, showing the importance of the hippocampus in controlling motor skill learning.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Plant Sciences
Bilqis Abiola Lawal, Yusuf Oloruntoyin Ayipo, Abisola Oyindamola Adekunle, Mohammed Otuofu Amali, Umar Muhammad Badeggi, Waleed A. Alananzeh, Mohd Nizam Mordi
Summary: This study found that the methanolic extract of Datura metel has potential therapeutic effects for Parkinson's disease, improving motor coordination and reducing muscle rigidity. The mechanism of action may be through multi-target inhibition of several key targets.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Neurosciences
Kelly F. Paton, Sheein Hong, Andrew Biggerstaff, Bronwyn M. Kivell
Summary: This study investigates the behavioral deficits associated with cuprizone-induced demyelination in male and female mice. The results show sex differences in motor coordination and anxiety-like behaviors, providing a better understanding of the behavioral aspects of cuprizone-induced demyelination.
Article
Anesthesiology
Jo Nijs, Astrid Lahousse, Cesar Fontaine-de-las-Penas, Pascal Madeleine, Christel Fontaine, Tomohiko Nishigami, Christine Desmedt, Marian Vanhoeij, Kenza Mostaqim, Antonio I. Cuesta-Vargas, Eleni Kapreli, Paraskevi Bilika, Andrea Polli, Laurence Leysen, Omer Elma, Eva Roose, Emma Rheel, Sevilay Tumkaya Yilmaz, Liesbet De Baets, Eva Huyamans, Ali Turk, Ismail Saracoglu
Summary: Pain after cancer is often underestimated and undertreated. Precision medicine offers a way to classify patients into different subgroups based on their individual characteristics and tailor treatment accordingly. The application of precision medicine to post-cancer pain is an emerging issue, particularly in identifying and treating nociplastic pain. The 2021 IASP clinical criteria provide a framework for classifying and treating nociplastic pain in cancer patients, and the CANPPHE Network aims to implement and improve this approach through a diagnostic manual and case illustrations.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Behavioral Sciences
Haiwang Ji, Xiang Jin, Qing Zhang, Yuan Zhou, Chan Zhu, Yan Yang, Zongxiang Tang, Guang Yu, Changming Wang
Summary: This study investigates the motor impairment in cancer induced bone pain (CIBP) and finds that tumor growth and pain severely impair motor coordination and balance. Different treatment methods also have an impact on pain and motor behavior, providing new clues for investigating the mechanisms of CIBP.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Shijie Liu, Si-Tong Chen, Yujun Cai
Summary: This study aimed to investigate the relationship between executive functions and gross motor skills in Chinese children aged 9-10 years, as well as gender differences. The results showed a weak association between gross motor coordination and certain aspects of executive functions, and gender influenced this relationship. Girls with better motor coordination skills had shorter reaction times, highlighting the relationship between gross motor coordination and complex cognitive processes.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Raphael Hamel, Jean-Francois Lepage, Pierre-Michel Bernier
Summary: Anterograde interference occurs when two opposite or identical tasks are learned in close temporal succession, suggesting that interference is not solely due to competing memories. The degree of overlap between neural networks involved in learning the tasks influences the level of interference, indicating that overlapping neural networks are required for interference to occur. The study suggests that learning-specific neural networks should be maximally dissociated to minimize interference from previous learning sessions.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Clinical Neurology
Licia Grazzi, Paul Rizzoli
Summary: The study suggests that lifestyle changes during a COVID-19 lockdown in the Netherlands led to improvement in migraine symptoms, highlighting the potential impact of behavioral interventions alongside traditional pharmaceutical treatments.
NATURE REVIEWS NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tiziana Adage, Francesca del Bene, Francesco Fiorentini, Robert P. Doornbos, Christina Zankl, Michael R. Bartley, Andreas J. Kungl
Article
Pharmacology & Pharmacy
Tiziana Adage, Viktoria Konya, Corinna Weber, Elisabeth Strutzmann, Thomas Fuchs, Christina Zankl, Tanja Gerlza, Dalibor Jeremic, Akos Heinemann, Andreas J. Kungl
EUROPEAN JOURNAL OF PHARMACOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Martha Gschwandtner, Martin U. Trinker, Bianca Hecher, Tiziana Adage, Simi Ali, Andreas J. Kungl
Article
Biochemistry & Molecular Biology
Oliver J. McElvaney, Niamh O'Reilly, Michelle White, Noreen Lacey, Kerstin Pohl, Tanja Gerlza, David A. Bergin, Hilary Kerr, Cormac McCarthy, M. Emmet O'Brien, Tiziana Adage, Andreas J. Kungl, Emer P. Reeves, Noel G. McElvaney
MOLECULAR IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Tanja Gerlza, Sophie Winkler, Aid Atlic, Christina Zankl, Viktoria Konya, Nikola Kitic, Elisabeth Strutzmann, Kerstin Knebl, Tiziana Adage, Akos Heinemann, Roland Weis, Andreas J. Kungl
PROTEIN ENGINEERING DESIGN & SELECTION
(2015)
Article
Neurosciences
Martha Gschwandtner, Anna Maria Piccinini, Tanja Gerlza, Tiziana Adage, Andreas J. Kungl
NEUROSCIENCE LETTERS
(2016)
Article
Oncology
Marko Roblek, Elisabeth Strutzmann, Christina Zankl, Tiziana Adage, Mathias Heikenwalder, Aid Atlic, Roland Weis, Andreas Kungl, Lubor Borsig
Article
Biochemistry & Molecular Biology
Angelika Falsone, Veronica Wabitsch, Elena Geretti, Heide Potzinger, Tanja Gerlza, James Robinson, Tiziana Adage, Mauro M. Teixeira, Andreas J. Kungl
BIOSCIENCE REPORTS
(2013)
Article
Pharmacology & Pharmacy
Tiziana Adage, Anna-Maria Piccinini, Angelika Falsone, Martin Trinker, James Robinson, Bernd Gesslbauer, Andreas J. Kungl
BRITISH JOURNAL OF PHARMACOLOGY
(2012)
Review
Biochemical Research Methods
Bernd Gesslbauer, Martina Theuer, Daniela Schweiger, Tiziana Adage, Andreas J. Kungl
EXPERT REVIEW OF PROTEOMICS
(2013)
Article
Clinical Neurology
Simon H. Bayerl, Adnan Ghori, Melina Nieminen-Kelhae, Tiziana Adage, Joerg Breitenbach, Peter Vajkoczy, Vincent Prinz
JOURNAL OF NEUROSURGERY
(2020)
Article
Biochemistry & Molecular Biology
T. Gerlza, C. Trojacher, D. Jeremic, E. Krieger, T. Adage, A. Kungl
Review
Biochemistry & Molecular Biology
Alexandra Pum, Maria Ennemoser, Tiziana Adage, Andreas J. Kungl
Summary: The presence and involvement of specific chemokines are crucial for the development and progression of COVID-19, leading to severe respiratory distress syndrome and pneumonia with fatal consequences. Cytokine storm and the resulting cytokine release syndrome are pathophysiological hallmarks in severe cases of COVID-19 infections, where chemokines and other cytokines are highly upregulated and cause harmful effects. There are therapeutics in clinical development targeting these factors to potentially treat COVID-19 infections.
Article
Hematology
Tanja Gerlza, Christina Trojacher, Nikola Kitic, Tiziana Adage, Andreas J. Kungl
Summary: Heparan sulfate proteoglycans (HSPGs) are widely distributed in human tissues, playing important roles in cell-cell communication. They are of therapeutic interest in cancer, inflammation, and infectious diseases. Current medical approaches aim to antagonize HSPG function in pathology.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Martha Gschwandtner, Elisabeth Strutzmann, Mauro M. Teixeira, Hans J. Anders, Maria Diedrichs-Moehring, Tanja Geriza, Gerhild Wildner, Remo C. Russo, Tiziana Adage, Andreas J. Kungl
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
