Selective PDE5A inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin II-induced heart failure in vivo

Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP)

(2012) Christian Kuhn et al.   BASIC RESEARCH IN CARDIOLOGY

Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts

(2012) Saisudha Koka et al.   BASIC RESEARCH IN CARDIOLOGY

S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling

(2012) H. Christian Volz et al.   BASIC RESEARCH IN CARDIOLOGY

Chronic Inhibition of cGMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy

(2012) Elisa Giannetta et al.   CIRCULATION

Long-Term Effects of Sildenafil in a Rat Model of Chronic Mitral Regurgitation

(2012) Kyung-Hee Kim et al.   CIRCULATION

Mechanical load-dependent cardiac ER stress in vitro and in vivo: Effects of preload and afterload

(2012) Karl Toischer et al.   FEBS LETTERS

Role of Heart Rate Reduction in the Prevention of Experimental Heart Failure

(2012) Peter Moritz Becher et al.   HYPERTENSION

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

(2011) Clint L. Miller et al.   BASIC RESEARCH IN CARDIOLOGY

Deficiency in TIMP-3 increases cardiac rupture and mortality post-myocardial infarction via EGFR signaling: beneficial effects of cetuximab

(2011) Lamis Hammoud et al.   BASIC RESEARCH IN CARDIOLOGY

Reduced Degradation of the Chemokine MCP-3 by Matrix Metalloproteinase-2 Exacerbates Myocardial Inflammation in Experimental Viral Cardiomyopathy

(2011) Dirk Westermann et al.   CIRCULATION

Sildenafil Preserves Lung Endothelial Function and Prevents Pulmonary Vascular Remodeling in a Rat Model of Diastolic Heart Failure

(2011) Jun Yin et al.   Circulation-Heart Failure

Cardiac Uses of Phosphodiesterase-5 Inhibitors

(2011) Bryan G. Schwartz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Novel therapeutic targets for the treatment of heart failure

(2011) Juan Tamargo et al.   NATURE REVIEWS DRUG DISCOVERY

PDE5A suppression of acute β-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation

(2010) Dong I. Lee et al.   BASIC RESEARCH IN CARDIOLOGY

Differential Cardiac Remodeling in Preload Versus Afterload

(2010) Karl Toischer et al.   CIRCULATION

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

Transcriptional and posttranscriptional regulators of biglycan in cardiac fibroblasts

(2009) Karen Tiede et al.   BASIC RESEARCH IN CARDIOLOGY

Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure

(2009) Dirk Westermann et al.   BASIC RESEARCH IN CARDIOLOGY

Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy

(2009) D. Westermann et al.   DIABETES

Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

(2009) Stephane Heymans et al.   EUROPEAN JOURNAL OF HEART FAILURE

Aliskiren Enhances the Protective Effects of Valsartan Against Cardiovascular and Renal Injury in Endothelial Nitric Oxide Synthase–Deficient Mice

(2009) Eiichiro Yamamoto et al.   HYPERTENSION

Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-Existing Advanced Hypertrophy Caused by Pressure Overload

(2009) Takahiro Nagayama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Potential novel pharmacological therapies for myocardial remodelling

(2008) U. Landmesser et al.   CARDIOVASCULAR RESEARCH

Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction

(2008) D. Westermann et al.   CIRCULATION

Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice

(2008) Alexander Riad et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure

(2008) Cathrine Husberg et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tackling heart failure in the twenty-first century

(2008) James O. Mudd et al.   NATURE