Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells

Induction of autophagic cell death by a novel molecule Is increased by hypoxia

(2014) Marco Tafani et al.   Autophagy

Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3

(2014) Hiroshi Aoki et al.   Autophagy

Cardiac glycosides block cancer growth through HIF-1α- and NF-κB-mediated Plk1

(2013) Chuan-Ming Xie et al.   CARCINOGENESIS

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

(2013) Gabriel Leprivier et al.   CELL

1,4-dihydroxy-2-naphthoic Acid Induces Apoptosis in Human Keratinocyte: Potential Application for Psoriasis Treatment

(2013) Chong-Fai Mok et al.   Evidence-based Complementary and Alternative Medicine

CaMKI  Regulates AMP Kinase-Dependent, TORC-1-Independent Autophagy during Lipopolysaccharide-Induced Acute Lung Neutrophilic Inflammation

(2013) L. Guo et al.   JOURNAL OF IMMUNOLOGY

Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells

(2012) Yan Cheng et al.   Autophagy

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

(2012) Lin Li et al.   CELLULAR SIGNALLING

Foot-and-Mouth Disease Virus Induces Autophagosomes during Cell Entry via a Class III Phosphatidylinositol 3-Kinase-Independent Pathway

(2012) S. Berryman et al.   JOURNAL OF VIROLOGY

Therapeutic targets in cancer cell metabolism and autophagy

(2012) Heesun Cheong et al.   NATURE BIOTECHNOLOGY

Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer

(2012) Ibrahim Tekedereli et al.   PLoS One

eEF-2 kinase, another meddler in the “Yin and Yang” of Akt–mediated cell fate?

(2011) Yan Cheng et al.   Autophagy

eEF-2 Kinase Dictates Cross-Talk between Autophagy and Apoptosis Induced by Akt Inhibition, Thereby Modulating Cytotoxicity of Novel Akt Inhibitor MK-2206

(2011) Y. Cheng et al.   CANCER RESEARCH

Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation

(2011) Chuan-Ming Xie et al.   FREE RADICAL BIOLOGY AND MEDICINE

1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) Induces Phosphorylation of Eukaryotic Elongation Factor-2 (eEF2)

(2011) Zehan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage and autophagy

(2011) Humberto Rodriguez-Rocha et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

(2010) Marta M. Lipinski et al.   DEVELOPMENTAL CELL

Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio

(2010) Qingqing Liu et al.   FASEB JOURNAL

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation

(2010) Atsushi Nakano et al.   NATURE CELL BIOLOGY

Cytoprotective Effect of the Elongation Factor-2 Kinase-Mediated Autophagy in Breast Cancer Cells Subjected to Growth Factor Inhibition

(2010) Yan Cheng et al.   PLoS One

Modeling Oncogenic Signaling in Colon Tumors by Multidirectional Analyses of Microarray Data Directed for Maximization of Analytical Reliability

(2010) Magdalena Skrzypczak et al.   PLoS One

Astrocyte elevated gene-1 induces protective autophagy

(2010) S. K. Bhutia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses

(2009) Bénédicte F. Py et al.   Autophagy

Nutrient-dependent regulation of autophagy through the target of rapamycin pathway: Figure 1

(2009) Yu-Yun Chang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Silencing of Elongation Factor-2 Kinase Potentiates the Effect of 2-Deoxy-D-Glucose against Human Glioma Cells through Blunting of Autophagy

(2009) H. Wu et al.   CANCER RESEARCH

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

Cell-Specific Induction of Apoptosis by Rationally Designed Bivalent Aptamer-siRNA Transcripts Silencing Eukaryotic Elongation Factor 2

(2008) Ulrich Wullner et al.   CURRENT CANCER DRUG TARGETS

Autophagy–physiology and pathophysiology

(2008) Yasuo Uchiyama et al.   HISTOCHEMISTRY AND CELL BIOLOGY