Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration
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Title
Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration
Authors
Keywords
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Journal
Future Medicinal Chemistry
Volume 4, Issue 17, Pages 2153-2161
Publisher
Future Science, LTD
Online
2012-11-29
DOI
10.4155/fmc.12.169
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Note: Only part of the references are listed.- Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
- (2016) Orsolya M. Palacios et al. Aging-US
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- (2014) Nektarios Tavernarakis et al. Autophagy
- Rapamycin slows aging in mice
- (2012) John E. Wilkinson et al. AGING CELL
- Protein-oxidized phospholipid interactions in cellular signaling for cell death: From biophysics to clinical correlations
- (2012) Paavo K.J. Kinnunen et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)
- (2012) Anu Kauppinen et al. IMMUNOLOGY LETTERS
- Neovascular Age-Related Macular Degeneration
- (2012) Daniele Veritti et al. OPHTHALMOLOGICA
- Ranibizumab versus Bevacizumab to Treat Neovascular Age-related Macular Degeneration
- (2012) Usha Chakravarthy et al. OPHTHALMOLOGY
- The 5HT1a Receptor Agonist 8-Oh DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium
- (2012) Prajitha Thampi et al. PLoS One
- AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
- (2011) Ken Inoki et al. Annual Review of Pharmacology and Toxicology
- Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
- (2011) Dun-Sheng Yang et al. Autophagy
- AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure
- (2011) C. Beauloye et al. CARDIOVASCULAR RESEARCH
- Autophagy: Renovation of Cells and Tissues
- (2011) Noboru Mizushima et al. CELL
- p53 represses autophagy in a cell cycle-dependent fashion
- (2011) Ezgi Tasdemir et al. CELL CYCLE
- AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function
- (2011) D. G. Hardie GENES & DEVELOPMENT
- Interplay between histone deacetylases and autophagy - from cancer therapy to neurodegeneration
- (2011) Oliver Trüe et al. IMMUNOLOGY AND CELL BIOLOGY
- Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of theSirt3Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype
- (2011) Albert Giralt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme
- (2011) Chao Peng et al. MOLECULAR & CELLULAR PROTEOMICS
- The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
- (2011) Maria M. Mihaylova et al. NATURE CELL BIOLOGY
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Control of autophagy as a therapy for neurodegenerative disease
- (2011) Harry Harris et al. Nature Reviews Neurology
- Fighting neurodegeneration with rapamycin: mechanistic insights
- (2011) Jordi Bové et al. NATURE REVIEWS NEUROSCIENCE
- Sirtuins, Aging, and Medicine
- (2011) Leonard Guarente NEW ENGLAND JOURNAL OF MEDICINE
- Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration
- (2011) NEW ENGLAND JOURNAL OF MEDICINE
- The 1-year Results of CLEAR-IT 2, a Phase 2 Study of Vascular Endothelial Growth Factor Trap-Eye Dosed As-needed After 12-week Fixed Dosing
- (2011) Jeffrey S. Heier et al. OPHTHALMOLOGY
- CCR3 and Choroidal Neovascularization
- (2011) Yiwen Li et al. PLoS One
- Mature Peripheral RPE Cells Have an Intrinsic Capacity to Proliferate; A Potential Regulatory Mechanism for Age-Related Cell Loss
- (2011) Ioannis Kokkinopoulos et al. PLoS One
- 5′-Adenosine Monophosphate-Activated Protein Kinase–Mammalian Target of Rapamycin Axis As Therapeutic Target for Age-Related Macular Degeneration
- (2011) Juha M.T. Hyttinen et al. REJUVENATION RESEARCH
- Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
- (2011) J. Du et al. SCIENCE
- Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
- (2010) Richard C. Scarpulla BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Differential roles of AMPKα1 and AMPKα2 in regulating 4-HNE-induced RPE cell death and permeability
- (2010) Suofu Qin et al. EXPERIMENTAL EYE RESEARCH
- SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model
- (2010) Yu Wang et al. FEBS LETTERS
- DNA damage and repair in age-related macular degeneration
- (2010) Janusz Blasiak Frontiers in Bioscience-Landmark
- An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis
- (2010) Muriel Mari et al. JOURNAL OF CELL BIOLOGY
- mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice
- (2010) Chen Zhao et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2010) Tong SHI et al. Journal of Digestive Diseases
- Network organization of the human autophagy system
- (2010) Christian Behrends et al. NATURE
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- (2010) Zhifen Yang et al. NATURE CELL BIOLOGY
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- (2010) Xingxing Kong et al. PLoS One
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- (2010) Cian J. Lynch et al. PLoS One
- -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)
- (2010) J. S. Oakhill et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2010) D. F. Egan et al. SCIENCE
- Heat shock proteins as gatekeepers of proteolytic pathways—Implications for age-related macular degeneration (AMD)
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- (2008) John Paul SanGiovanni ARCHIVES OF OPHTHALMOLOGY
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- (2008) S Sarkar et al. CELL DEATH AND DIFFERENTIATION
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- (2008) Marcella Fulco et al. DEVELOPMENTAL CELL
- Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro
- (2008) A. Stahl et al. FEBS LETTERS
- α2 but Not α1 AMP-activated Protein Kinase Mediates Oxidative Stress-induced Inhibition of Retinal Pigment Epithelium Cell Phagocytosis of Photoreceptor Outer Segments
- (2008) Suofu Qin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1
- (2008) Fan Lan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Age Lipid A2E and Mitochondrial Dysfunction Synergistically Impair Phagocytosis by Retinal Pigment Epithelial Cells
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- Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells
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- SIRT1 Promotes Differentiation of Normal Human Keratinocytes
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- Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors
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- The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy
- (2008) Naonobu Fujita et al. MOLECULAR BIOLOGY OF THE CELL
- Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
- (2008) Eisuke Itakura et al. MOLECULAR BIOLOGY OF THE CELL
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
- (2008) Eriko Michishita et al. NATURE
- Sirtuins — novel therapeutic targets to treat age-associated diseases
- (2008) Siva Lavu et al. NATURE REVIEWS DRUG DISCOVERY
- Age-Related Macular Degeneration
- (2008) Rama D. Jager et al. NEW ENGLAND JOURNAL OF MEDICINE
- Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
- (2008) Q. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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