Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells

Pancreatic stellate cells: Aiding and abetting pancreatic cancer progression

(2020) Srinivasa P. Pothula et al.   PANCREATOLOGY

Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells

(2019) Daniela Lenggenhager et al.   Cells

Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage

(2019) Keane K.Y. Lai et al.   Current Molecular Pharmacology

β-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis

(2019) Tomoko Hirakawa et al.   Scientific Reports

Inhibition of canonical WNT signaling pathway by β-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12

(2018) Büsra Öztürk Akcora et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Rising Star in Pancreatic Diseases: Pancreatic Stellate Cells

(2018) Ran Xue et al.   Frontiers in Physiology

Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage

(2018) Masaya Ono et al.   PLoS One

Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model

(2017) Yuko Tokunaga et al.   Scientific Reports

Beta-catenin participates in dialysate-induced peritoneal fibrosisviaenhanced peritoneal cell epithelial-to-mesenchymal transition

(2017) Shuiyu Ji et al.   FEBS Open Bio

Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial

(2017) Kiminori Kimura et al.   EBioMedicine

Kat3 coactivators in somatic stem cells and cancer stem cells: biological roles, evolution, and pharmacologic manipulation

(2016) Paul D. Thomas et al.   CELL BIOLOGY AND TOXICOLOGY

Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis

(2016) Przemyslaw Blyszczuk et al.   EUROPEAN HEART JOURNAL

Inhibition of β-catenin signaling protects against CTGF-induced alveolar and vascular pathology in neonatal mouse lung

(2016) Min Rong et al.   PEDIATRIC RESEARCH

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

(2015) C. J. Whatcott et al.   CLINICAL CANCER RESEARCH

β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis

(2015) Satdarshan Pal Monga   GASTROENTEROLOGY

Genetics and Genetic Testing in Pancreatic Cancer

(2015) David C. Whitcomb et al.   GASTROENTEROLOGY

Retinoic Acid Ameliorates Pancreatic Fibrosis and Inhibits the Activation of Pancreatic Stellate Cells in Mice with Experimental Chronic Pancreatitis via Suppressing the Wnt/β-Catenin Signaling Pathway

(2015) Wenqin Xiao et al.   PLoS One

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis

(2013) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment

(2013) Minoti V. Apte et al.   GASTROENTEROLOGY

Pancreatic Stellate Cell Models for Transcriptional Studies of Desmoplasia-Associated Genes

(2013) Angela Mathison et al.   PANCREATOLOGY

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Interactions Between β-Catenin and Transforming Growth Factor-β Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP)

(2012) Beiyun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic stellate cells: a starring role in normal and diseased pancreas

(2012) Minoti V. Apte et al.   Frontiers in Physiology

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells

(2010) Kazuhiro Kikuta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma

(2010) Tine S. Mantoni et al.   CANCER BIOLOGY & THERAPY

Neuropilin-1 Mediates Divergent R-Smad Signaling and the Myofibroblast Phenotype

(2010) Ying Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

(2008) A. Vonlaufen et al.   CANCER RESEARCH

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH