Review
Medicine, General & Internal
Yurie Otani, Tomotaka Shimura, Taketoshi Nogaki, Yoichi Ikenoya, Koichiro Oyake, Naomi Imaizumi, Yukiko Inoue, Shuhei Uruma, Sawa Kamimura, Yojiro Kawamura, Sei Kobayashi
Summary: This article reports a patient with IgG4-related Mikulicz's disease, but after detailed examination and strict diagnosis, it was finally confirmed as Sjogren syndrome. The article points out that careful differentiation between IgG4-related Mikulicz's disease and other diseases, as well as their diagnostic criteria, is necessary in the absence of an IgG4-related Mikulicz's disease diagnosis.
Review
Gastroenterology & Hepatology
Kazushige Uchida, Kazuichi Okazaki
Summary: The concept of autoimmune pancreatitis (AIP) was first proposed by Yoshida et al. in 1995. AIP has been accepted as a new pancreatic inflammatory disease and is now divided into two subtypes: type 1, which is associated with immunoglobulin G4 (IgG4) and IgG4-related disease, and type 2, characterized by neutrophil infiltration and granulocytic epithelial lesions (GEL). Recent research has provided more knowledge about type 1 AIP, which is more prevalent among the Japanese population compared to type 2. However, many details regarding the pathogenesis and progression of this disease remain unclear.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Immunology
Kosuke Minaga, Tomohiro Watanabe, Akane Hara, Tomoe Yoshikawa, Ken Kamata, Masatoshi Kudo
Summary: Activation of plasmacytoid dendritic cells (pDCs) can lead to autoimmune diseases like SLE, psoriasis, AIP, and IgG4-RD. Research has shown that IFN-I and IL-33 produced by pDCs play a key role in the development of AIP and IgG4-RD.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jiachen Liu, Wei Yin, Lisa S. Westerberg, Pamela Lee, Quan Gong, Yan Chen, Lingli Dong, Chaohong Liu
Summary: IgG(4)-RD is a newly discovered autoimmune disease characterized by elevated serum IgG(4) concentrations and multi-organ fibrosis. The pathogenesis of this disease involves abnormal adaptive immune cells and cytokines, including different types of T and B cells, and cytokines secreted by these cells, leading to fibrosis in multiple organs.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Siyu Wu, Haiqiang Wang
Summary: IgG4-related digestive diseases are a group of chronic inflammatory disorders that are often misdiagnosed as malignancies. A comprehensive understanding of these diseases remains challenging, and current diagnosis relies on integrated diagnostic criteria and specific organ involvement criteria. Further research is needed to elucidate the underlying mechanisms and explore potential treatments.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Ophthalmology
Tingting Ren, Rui Liu, Jing Li, Jianmin Ma
Summary: Sjogren's Syndrome (SS) and Mikulicz's disease (MD) share similarities in clinical manifestations, imaging, and pathology, leading to confusion in diagnosis. This case report highlights the importance of considering the differential diagnosis of SS and MD when the clinical manifestations are atypical. A comprehensive evaluation, including antibody testing, is crucial for accurate diagnosis.
Article
Gastroenterology & Hepatology
Qiaoyan Liu, Bo Li, Yikang Li, Yiran Wei, Bingyuan Huang, Jubo Liang, Zhengrui You, You Li, Qiwei Qian, Rui Wang, Jun Zhang, Ruiling Chen, Zhuwan Lyu, Yong Chen, Mingxia Shi, Xiao Xiao, Qixia Wang, Qi Miao, Jing-Yuan Fang, Merrill Eric Gershwin, Min Lian, Xiong Ma, Ruqi Tang
Summary: Comparative analysis of gut microbiome and metabolome in IgG4-SC and PSC patients revealed distinct host-microbe interactions that may contribute to disease pathogenesis, highlighting the uniqueness of IgG4-SC.
Review
Biochemistry & Molecular Biology
Mara Carsote, Claudiu Nistor
Summary: Recently, Riedel's thyroiditis has been classified as part of the larger spectrum of IgG4-related disease. This study aimed to review the latest data on Riedel's thyroiditis, particularly focusing on IgG4-related disease and IgG4-related thyroid disease. The analysis included a comprehensive review of articles and selected original studies, highlighting the importance of early suspicion for accurate diagnosis and prompt treatment.
Review
Biochemistry & Molecular Biology
Yoko Ogawa, Tsutomu Takeuchi, Kazuo Tsubota
Summary: Autoimmune epithelitis and chronic inflammation are characteristic features of the immune pathogenesis of Sjogren's syndrome (SS)-related dry eye disease, affecting the secretion of tear fluid and mucin. Dysfunction of ocular surface epithelium can lead to dry eye disease, with potential targets for treatment including various molecules in tear film, cornea, conjunctiva, lacrimal glands, and meibomian glands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Koichiro Miyagawa, Keiichiro Kumamoto, Nobuhiko Shinohara, Tatsuyuki Watanabe, Shinsuke Kumei, Akitoshi Yoneda, Satoru Nebuya, Yudai Koya, Shinji Oe, Keiichiro Kume, Ichiro Yoshikawa, Masaru Harada
Summary: This study reports a case of early gastric cancer with concomitant autoimmune pancreatitis. The findings suggest that gastric cancer may activate an IgG4-related immune response, leading to the development of autoimmune pancreatitis.
Article
Geriatrics & Gerontology
Nan Duan, Zhiyan Li, Yong Fan, Yaping Jiang, Haixia Li
Summary: This study investigated the clinical data and laboratory markers associated with renal function damage or renal involvement in pSS patients. The results showed that age, urea, chlorine, and anti-SSA were highly associated with renal injury in pSS. Early screening for autoantibodies would be meaningful for evaluation and prevention of renal injury in pSS.
Article
Immunology
Yung-Hsiang Chao, Chin-Hsiu Liu, Yu-An Pan, Fu-Shun Yen, Jeng-Yuan Chiou, James Cheng-Chung Wei
Summary: This population-based cohort study found that patients with a history of endometriosis have an increased risk of developing Sjogren's syndrome, especially within the first five years after diagnosis, and in the age group of 20-39.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Atsushi Tanaka, Kenji Notohara
Summary: IgG4-related disease is a chronic inflammatory disease that may affect multiple organs of the body, characterized by elevated serum IgG4 levels and massive infiltration of IgG4(+) plasma cells in damaged tissues. The phenotypes of IgG4-RD in the liver, such as IgG4-AIH and IgG4-hepatopathy, along with their clinical characteristics, remain to be established due to the lack of consensus.
HEPATOLOGY RESEARCH
(2021)
Review
Immunology
Xinhe Zhang, Xing Jin, Lin Guan, Xuyong Lin, Xuedan Li, Yiling Li
Summary: IgG4-related disease is an immune-mediated chronic, systemic, and autoinflammatory disease that can affect various organs throughout the body. The most commonly affected areas are the pancreas and biliary system. This article reports two special cases involving atrophic gastritis and intestinal polyps, providing empirical and theoretical basis for clinical diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Han Wang, Lan Yao, Ligang Wang, Xixi Sun, Bin Huang
Summary: Few reports have described pancreatic or extrapancreatic malignancies in AIP patients, and no association between AIP and bile duct adenocarcinoma has been previously confirmed. This case discusses the differentiation between AIP and malignancy, recent research progress, and the correlation between the two diseases, highlighting the importance of carefully evaluating patients with AIP to rule out potential tumors, as well as the critical need for follow-up treatment.
BMC GASTROENTEROLOGY
(2021)