Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Review
Virology
Jinyan Xie, Mingshu Wang, Anchun Cheng, Renyong Jia, Dekang Zhu, Mafeng Liu, Shun Chen, XinXin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Qihui Luo, Yin Wang, Zhiwen Xu, Zhengli Chen, Ling Zhu, Yunya Liu, Yanling Yu, Ling Zhang, Xiaoyue Chen
Summary: The serious consequences of chronic hepatitis virus infections are related to the viral invasion strategy and escape mechanism, with suppressor of cytokine signaling (SOCS) proteins playing an important role in this process.
Review
Immunology
Rahul Pandey, Marina Bakay, Hakon Hakonarson
Summary: Autoimmune diseases result from abnormal immune responses against self-tissue, and disruptions in the JAK-STAT signaling pathway, where SOCS proteins play critical roles, are closely linked to their development. Emerging therapeutic strategies involving JAK-STAT inhibitors and SOCS mimetics show promise in modulating immune responses and alleviating autoimmune manifestations. Further research and clinical studies are needed to evaluate their effectiveness and safety in personalized treatment approaches for autoimmune conditions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shunfen Zhang, Ruqing Zhong, Shanlong Tang, Hui Han, Liang Chen, Hongfu Zhang
Summary: The adverse effects of short-term megadose of antibiotics exposure on the gastrointestinal and liver tissue reactions in young children have been reported. However, studies on the harm and rescue measures of antibiotics from the perspective of the gut-liver system are lacking. In this study, baicalin was found to attenuate the lincomycin-induced changes in body weight, gut microbiota composition, intestinal morphology, immune-mediated injury and inflammation, liver dysfunction, and lipid metabolism. Baicalin improved immunity by regulating inflammatory cytokines and genes involved in T cell differentiation. It also improved liver function by regulating genes involved in bile acid secretion and lipid metabolism. Furthermore, baicalin improved the abundance of anti-inflammatory bacteria and reduced the abundance of pathogenic bacteria in lincomycin-treated mice. These findings suggest that baicalin can ameliorate antibiotic-induced injury and its associated complications such as liver disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Qianhui Li, Feng Chen, Fei Wang
Summary: Acute liver failure caused by drug overdose is a significant clinical problem. In addition to the direct toxicity of the drug, inflammation plays a crucial role in the development and severity of the disease. Understanding the involvement of immune cells and their effector molecules is essential for identifying new therapeutic targets.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Marta Duran-Guell, Roger Flores-Costa, Mireia Casulleras, Cristina Lopez-Vicario, Esther Titos, Alba Diaz, Jose Alcaraz-Quiles, Raquel Horrillo, Montserrat Costa, Javier Fernandez, Vicente Arroyo, Joan Claria
Summary: Albumin not only reduces leukocyte cytokine production but also has the ability to protect tissues from the damaging actions of inflammatory mediators, particularly in the context of liver injury.
Letter
Gastroenterology & Hepatology
Ken Sato, Yuichi Yamazaki, Toshio Uraoka
Summary: Investigational treatments/drugs for COVID-19 need to consider hepatotoxicity, which may affect liver function, and therefore efforts should be made to control the risk of drug-induced liver injury while delaying disease progression.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Pharmacology & Pharmacy
Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens, Erich A. Peterson, Donald J. Johann, Felicia D. Allard, Eric U. Yee, Sandra S. McCullough, Laura P. James, Brian N. Finck, Mitchell R. McGill
Summary: This study demonstrates the beneficial effects of exogenous phosphatidic acid in acetaminophen toxicity by activating IL-6 signaling. However, despite the importance of PA in liver repair, exogenous PA did not alter regeneration.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Cell Biology
Louise M. C. Webb, Sigrid Fra-Bido, Silvia Innocentin, Louise S. Matheson, Noudjoud Attaf, Alexandre Bignon, Julien Novarino, Nicolas Fazilleau, Michelle A. Linterman
Summary: Ageing profoundly impacts immune system by affecting Tfh cell formation, promoting early Tfh cell differentiation but not increasing GC-Tfh cells. Ageing alters TCR signalling, leading to increased expression of RBPJ, and modulation of RBPJ or Notch rescues age-associated early Tfh cell differentiation.
Article
Immunology
Hyun Yang, Ji Won Han, Jae Jun Lee, Ahlim Lee, Sung Woo Cho, Pu Reun Rho, Min-Woo Kang, Jeong Won Jang, Eun Sun Jung, Jong Young Choi, Pil Soo Sung, Si Hyun Bae
Summary: This study investigated the phenotypes and clinical implications of liver-infiltrating immune cells in idiosyncratic drug-induced liver injury (DILI). The results showed that activated CD8+ T cells and mononuclear phagocytes are associated with drug-induced liver injury. Therefore, steroids are suggested as a potential treatment option for idiosyncratic DILI.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Meng Li, Qiong Luo, Yanyan Tao, Xin Sun, Chenghai Liu
Summary: This article reviews the accumulated literature on drug-induced liver injury (DILI) with evidence-based medicine researches and discusses the limitations of clinical studies and the prospective development for DILI therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sabine Weber, Alexander L. Gerbes
Summary: Drug-induced liver injury (DILI) is a rare but potentially severe adverse drug event, which poses a major challenge for diagnosis in clinical practice and pharmacovigilance. Efforts have been made to establish diagnostic testing methods and biomarkers for safe diagnosis and differentiation from other liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Gastroenterology & Hepatology
Steven Trinh, Nicholas Batt, Rohit Sawhney, Amanda Nicoll
Summary: Drug-induced liver injury (DILI) is a rare cause of acute liver injury. Bjornsson et al. establish a European DILI registry to assess the clinical features and outcomes of DILI in several European countries. The authors highlight the need for reporting potential outcomes from pharmacotherapy to determine the role of medical therapy for DILI, as this information is currently lacking.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Katerina Roma, Salman Mohammed, Blake Sieck, Katrina Naik, Shahid Wahid
Summary: Alternative medicine supplements, such as kratoms, have become a significant cause of liver injury in the US. Reports of adverse events linked to kratom use are increasing, including liver injury, organ dysfunction, and even death. The need for increased regulation and public awareness of the risks associated with kratom is emphasized.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yi-Shin Huang, Ting-Tsung Chang, Cheng-Yuan Peng, Gin-Ho Lo, Chao-Wei Hsu, Chi-Tan Hu, Yi-Hsiang Huang
Summary: The study found that herbal and dietary supplements accounted for more than one-fifth of drug-induced liver injuries in Taiwan, and patients with HILI were more severe and had a higher mortality rate compared to those with CILI. Hepatitis B carriers, individuals with elevated baseline liver tests, and users of crude herbs may face a higher risk of HILI-related mortality. Prudent use of HDS is recommended for these high-risk individuals.
HEPATOLOGY INTERNATIONAL
(2021)
