Article
Biochemistry & Molecular Biology
Robert Hauffe, Michaela Rath, Wilson Agyapong, Wenke Jonas, Heike Vogel, Tim J. Schulz, Maria Schwarz, Anna P. Kipp, Matthias Bluher, Andre Kleinridders
Summary: The intake of high-fat diets leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium can protect against the development of diet-induced insulin resistance. However, selenium might not be able to attenuate insulin resistance in the presence of obesity.
Article
Endocrinology & Metabolism
Britta Kunkemoeller, Kuangyang Chen, Sam M. Lockhart, Xuanchun Wang, Christian Rask-Madsen
Summary: Endothelial cell insulin resistance is a major contributor to diabetic complications. The study shows that CITED2 inhibits endothelial insulin signaling through the PI3K/Akt pathway by repressing HIF-dependent IRS-2 expression, and deletion of CITED2 enhances insulin signaling. Therefore, CITED2 is a novel and promising target to improve insulin sensitivity in endothelial cells and prevent vascular complications in diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Paola A. Ramos, Kelli A. Lytle, Danae Delivanis, Soren Nielsen, Nathan K. LeBrasseur, Michael D. Jensen
Summary: The study found that there were no defects in insulin receptor signaling at the Akt/AS160 level in the muscles of obese individuals, indicating uncertainties in the mechanism of muscle insulin resistance in obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Agriculture, Multidisciplinary
Juciane de Abreu Ribeiro Pereira, Maria de Fatima Piccolo Barcelos, Eduardo Valerio Villas Boas, Roberta Hilsdorf Piccoli, Janina de Sales Guilarducci, Rafaela Correa Pereira, Jose Rodrigo Pauli, Eric Batista Ferreira, Michel Cardoso de Angelis-Pereira, Dennys Esper Cintra
Summary: This study found that the combination of yacon flour and yogurt with two strains of probiotics had positive effects on metabolic parameters, inflammatory and insulin signaling proteins in diet-induced obese mice. The combination resulted in decreased body weight, fasting glucose, and triacylglycerol levels, as well as reduced fat accumulation. Additionally, it decreased inflammatory markers and improved insulin signaling. These findings suggest that the use of prebiotics and probiotics in food can counteract obesity-associated inflammation and improve insulin resistance in the short term.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Sandip Mukherjee, Molee Chakraborty, Jake Haubner, Glen Ernst, Michael DePasquale, Danielle Carpenter, James C. Barrow, Anutosh Chakraborty
Summary: Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns. LI-2242, an inhibitor of the inositol pyrophosphate pathway, shows potential therapeutic effects in obesity and NAFLD by reducing body weight, improving glycemic parameters, and ameliorating hepatic steatosis. LI-2242 also enhances mitochondrial oxygen consumption rate and insulin signaling in adipocytes and hepatocytes in vitro.
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Kyung-Ho Min, Wan Lee
Summary: This study reveals that excessive intake of saturated fatty acids (SFA) can lead to obesity and insulin resistance. The induction of miR-183-5p by SFA impairs insulin signaling, leading to the development of hepatic insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Sasivimon Promsan, Laongdao Thongnak, Nattavadee Pengrattanachot, Nichakorn Phengpol, Prempree Sutthasupha, Anusorn Lungkaphin
Summary: Agomelatine protected against obesity-induced kidney injury through regulation of the ROS and AMPK-mTOR-autophagy signaling pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Lorena Orostica, Isis Astorga, Francisca Plaza-Parrochia, Cristian Poblete, Rodrigo Carvajal, Victor Garcia, Carmen Romero, Margarita Vega
Summary: PCOS is an endocrine/metabolic disorder associated with insulin resistance and obesity. This study found that MTF can improve insulin and adiponectin signaling in endometrial tissues, independent of PCOS. This suggests that MTF may help improve insulin action and reproductive issues in women with obesity/PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Stepheny C. de Campos Zani, Myoungjin Son, Khushwant S. Bhullar, Catherine B. Chan, Jianping Wu
Summary: IRW has beneficial effects on body composition and glucose metabolism in HFD mice, improving glucose tolerance, reducing weight gain, and promoting glucose uptake in skeletal muscle through multiple signaling pathways.
Article
Endocrinology & Metabolism
Mayumi Nagashimada, Kazuki Sawamoto, Yinhua Ni, Hironori Kitade, Naoto Nagata, Liang Xu, Masuko Kobori, Naofumi Mukaida, Tatsuya Yamashita, Shuichi Kaneko, Tsuguhito Ota
Summary: The CX3CL1-CX3CR1 system regulates inflammation in obese mice by affecting adipose tissue macrophage recruitment and polarization, leading to insulin resistance. Deficiency in CX3CR1 signaling results in a dominant shift towards M1-polarized macrophages, exacerbating insulin resistance in obese mice. Therapies targeting CX3CL1-CX3CR1 system may be beneficial for treating type 2 diabetes by modulating M1/M2 macrophages.
Article
Endocrinology & Metabolism
Mayumi Nagashimada, Kazuki Sawamoto, Yinhua Ni, Hironori Kitade, Naoto Nagata, Liang Xu, Masuko Kobori, Naofumi Mukaida, Tatsuya Yamashita, Shuichi Kaneko, Tsuguhito Ota
Summary: The CX3CL1-CX3CR1 system is crucial in regulating inflammation, particularly in obese mice with adipose tissue inflammation and insulin resistance. Deficiency in CX3CR1 signaling leads to an increase in M1 polarized macrophages, worsening glucose tolerance and insulin resistance in obese mice. Targeting the CX3CL1-CX3CR1 system may be beneficial in treating type 2 diabetes by modulating M1/M2 macrophages.
Article
Plant Sciences
Zhimin Wu, Wenxin Yu, Weiju Ni, Cuiqin Teng, Weile Ye, Cuiping Yu, Yu Zeng
Summary: This study used LC-MS and network pharmacology to screen the active components and targets of Liupao tea water extract (LTWE), and predicted its anti-obesity targets and pathways. The results showed that LTWE inhibited the proliferation and differentiation of preadipocytes by regulating gene expression of adipogenic transcription factors and proinflammatory factors, and improved insulin resistance by activating the IRS-1/PI3K/AKT/GLUT4 pathway.
Article
Biochemistry & Molecular Biology
Ebru S. Selen, Michael J. Wolfgang
Summary: The study revealed that activation of mTORC1 by deleting TSC1 in the liver is not enough to suppress PPAR alpha signaling or ketogenesis after fasting.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Sourbh Suren Garg, Kriti Kushwaha, Rupal Dubey, Jeena Gupta
Summary: Obesity, a metabolic disorder, increases the risk for various diseases including metabolic inflammation, insulin resistance, and cardiovascular diseases. However, the mechanisms linking obesity with other metabolic diseases are not completely understood.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Nutrition & Dietetics
Thomas M. Barber, Stefan Kabisch, Harpal S. Randeva, Andreas F. H. Pfeiffer, Martin O. Weickert
Summary: Resveratrol, a polyphenol chemical found in many plant-based dietary products, has potential health benefits. After ingestion, it undergoes extensive metabolism, inhibits adipogenesis and fat accumulation, possesses anti-inflammatory effects, and may improve insulin sensitivity and inflammatory status. However, optimal dosage and benefits within the general population need further research.
Article
Pharmacology & Pharmacy
Mercedes Munoz, Elvira Lopez-Oliva, Estefano Pinilla, Claudia Rodriguez, Maria Pilar Martinez, Cristina Contreras, Alfonso Gomez, Sara Benedito, Javier Saenz-Medina, Luis Rivera, Dolores Prieto
Summary: The study investigated the impact of altered CYP enzymes in obese rats on oxidative stress and endothelial dysfunction in kidney preglomerular arteries. The results suggest that decreased CYP2C11/CYP2C23-derived vasodilator H2O2 and augmented CYP4A-derived 20-HETE contribute to endothelial dysfunction and vascular oxidative stress in obesity. CYP4A inhibitors show therapeutic potential for vascular complications associated with obesity-induced kidney injury.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Javier Saenz-Medina, Mercedes Munoz, Claudia Rodriguez, Ana Sanchez, Cristina Contreras, Joaquin Carballido-Rodriguez, Dolores Prieto
Summary: An epidemiological relationship between urolithiasis and cardiovascular diseases has been reported. Endothelial dysfunction is associated with both conditions. Oxidative stress is a key factor in the development of endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Laurent-Emmanuel Monfoulet, Maria Carmen Martinez
Summary: Extracellular vesicles, including nanovesicles derived from the endosome system, are gaining interest due to their potential role in cell-to-cell communication and biomarker use. Studies suggest that poor-quality diets may increase levels of circulating large EVs, but this can be countered by healthy foods and micronutrients. However, more research is needed to understand the content and biological functions of diet-induced EVs.
Review
Nutrition & Dietetics
Sayani Mukherjee, Silje Skrede, Edward Milbank, Ramaroson Andriantsitohaina, Miguel Lopez, Johan Ferno
Summary: Antipsychotic drugs play a crucial role in the treatment of schizophrenia and other psychoses. However, many of these drugs have side effects such as increased appetite, weight gain, and increased risk for diabetes and cardiovascular disease. Understanding the molecular mechanisms behind drug-induced hyperphagia is important for the development of new drugs and advancing our knowledge of appetite regulation.
FRONTIERS IN NUTRITION
(2022)
Article
Obstetrics & Gynecology
Pascal Froment, Ingrid Plotton, Cecilia Giulivi, Stephane Fabre, Rita Khoueiry, Nizar Mourad, Sandrine Horman, Christelle Rame, Charlene Rouillon, Jeremy Grandhaye, Yves Bigot, Claire Chevaleyre, Remy Le Guevel, Patricia Mallegol, Ramaroson Andriantsitohaina, Fabrice Guerif, Jerome Tamburini, Benoit Viollet, Marc Foretz, Joelle Dupont
Summary: The lack of alpha 1AMPK in granulosa cells impacts various biological processes and leads to a hyperandrogenic response.
HUMAN REPRODUCTION
(2022)
Article
Cell Biology
Javier Saenz-Medina, Mercedes Munoz, Claudia Rodriguez, Cristina Contreras, Ana Sanchez, Maria Jose Coronado, Elvira Ramil, Martin Santos, Joaquin Carballido, Dolores Prieto
Summary: This study found that urolithiasis leads to endothelial dysfunction in preglomerular arteries, accompanied by an increase in renal cortex superoxide generation and the development of vascular inflammation. Pathways involving xanthine oxidase, Nox1, and Nox2 also play a role in this process.
Article
Pharmacology & Pharmacy
Abir Salek, Mouna Selmi, Mahassen Barboura, M. Carmen Martinez, Leila Chekir-Ghedira, Ramaroson Andriantsitohaina
Summary: This study utilized small extracellular vesicles (sEVs) to enhance the stability and efficacy of berberine hydrochloride (BRB). The results showed that sEVs loaded with BRB had greater inhibitory effects on proliferation, migration, and capillary-like formation in tumor cells and endothelial cells compared to free BRB. Therefore, sEV-loaded BRB may be considered as an innovative delivery method to prevent tumorigenesis and angiogenesis.
Article
Endocrinology & Metabolism
Edward Milbank, Nathalia Dragano, Xavi Vidal-Gomez, Veronica Rivas-Limeres, Pablo Garrido-Gil, Mireille Wertheimer, Sylvain Recoquillon, Maria P. Pata, Jose Luis Labandeira-Garcia, Carlos Dieguez, Ruben Nogueiras, M. Carmen Martinez, Ramaroson Andriantsitohaina, Miguel Lopez
Summary: The study found that using a specific type of extracellular vesicles loaded with a defective AMPK alpha 1 gene can alleviate symptoms such as obesity and metabolic disorders in mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Cell Biology
Lionel Fizanne, Alexandre Villard, Nadia Benabbou, Sylvain Recoquillon, Raffaella Soleti, Erwan Delage, Mireille Wertheimer, Xavier Vidal-Gomez, Thibauld Oullier, Samuel Chaffron, M. Carmen Martinez, Michel Neunlist, Jerome Boursier, Ramaroson Andriantsitohaina
Summary: The study investigates the role of fEVs and cEVs in liver diseases such as NAFLD and NASH. NASH-fEVs were found to have deleterious effects, increasing intestinal permeability and reducing expression of tight junction proteins through the involvement of nmMLCK and lipopolysaccharide pathways.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Biochemistry & Molecular Biology
Javier Saenz-Medina, Jesus San Roman, Maria Rodriguez-Monsalve, Manuel Duran, Joaquin Carballido, Dolores Prieto, Angel Gil Miguel
Summary: This study aimed to evaluate the trends in hospitalization rates, features, costs, and the influence of metabolic syndrome traits on the prevalence and complications of nephrolithiasis. By analyzing hospitalization records from Spain, it was found that the hospitalization rate for nephrolithiasis remained stable at 56.7 per 100,000 inhabitants during the study period. The mortality rate was higher in elderly patients and was associated with comorbid conditions such as diabetes mellitus and hypertension.
Article
Biochemistry & Molecular Biology
Matthieu Ferragu, Luisa Vergori, Vincent Le Corre, Sarah Bellal, Maria del Carmen Martinez, Pierre Bigot
Summary: lEVs derived from kidney cancer patients may promote tumor growth and cancer progression, as demonstrated in a mouse model.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
