Article
Multidisciplinary Sciences
Ping Zhang, Le Su, Xiuyu Ji, Feifan Ma, Qiulin Yue, Chen Zhao, Song Zhang, Xin Sun, Kunlun Li, Lin Zhao
Summary: This study provides evidence that Cistanche deserticola Ma promotes adipogenesis and explores new signaling pathways involved in adipogenesis regulation.
Article
Biochemistry & Molecular Biology
Pilailak Channuwong, Kunthira Salae, Sumet Chongruchiroj, Henrique Cheng, Tanyawan Suantawee, Thavaree Thilavech, Sirichai Adisakwattana
Summary: This study investigated the inhibitory effects of anthocyanins on insulin fibril formation. The results showed that anthocyanins significantly reduced fibril formation, altered the structure of insulin, and interacted with insulin molecules. The presence of glycosides and hydroxyl groups on phenyl rings increased the inhibitory effect of anthocyanins, and they also attenuated insulin fibril-induced cytotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell Biology
Xin Lv, Jun Qiu, Tao Hao, Haoran Zhang, Haiping Jiang, Yang Tan
Summary: The study demonstrated that TSA inhibited adipogenesis in 3T3-L1 preadipocytes by activating the AMPK pathway, leading to decreased lipid accumulation. Furthermore, TSA was also able to reverse the weight gain and adipose tissue increase induced by a high-fat diet in obese mouse models.
Article
Biochemistry & Molecular Biology
Jinsoo Kim, Dohee Ahn, Sang J. Chung
Summary: This study identified chebulinic acid as a potential therapeutic agent for treating obesity by inhibiting PPP1CB activity and suppressing adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Francesca Molinari, Alessandra Feraco, Simone Mirabilii, Serena Saladini, Luigi Sansone, Enza Vernucci, Giada Tomaselli, Vincenzo Marzolla, Dante Rotili, Matteo A. Russo, Maria Rosaria Ricciardi, Agostino Tafuri, Antonello Mai, Massimiliano Caprio, Marco Tafani, Andrea Armani
Summary: The inhibition of SIRT5 stimulates brown adipogenesis in vitro, promoting the expression of brown adipocyte and mitochondrial markers and increasing lipolysis. This approach shows potential as a strategy to target obesity and type 2 diabetes by activating brown adipose tissue.
Article
Biochemistry & Molecular Biology
Jinming Peng, Wenjun Wen, Ruifeng Wang, Kaikai Li, Gengsheng Xiao, Chunmei Li
Summary: This study investigated the contribution of the galloyl group in polyphenols to their anti-adipogenic activity and its molecular mechanism. The presence of the galloyl moiety was found to be necessary for the inhibition of adipogenic differentiation, potentially by interfering with the early stages of differentiation and the downstream MAPK signaling pathway. These findings highlight the importance of galloylated polyphenols in suppressing adipocyte differentiation.
Article
Nutrition & Dietetics
Beegum Noorjahan Shijina, Achuthan Radhika, Sainulabdeen Sherin, Prabath Gopalakrishnan Biju
Summary: The indole alkaloid vindoline from Catharanthus roseus was found to have significant improvements in insulin resistance, oxidative stress, and inflammatory responses. It enhanced glucose metabolism and increased the expression of insulin receptors, alleviating symptoms of insulin resistance.
Article
Pharmacology & Pharmacy
Zhe Zhao, Fengying Gong, Lian Duan, Xiaorui Lv, Haijie Wu, Yan Tang, Huijuan Zhu, Xiaoguang Chen
Summary: The study found that somatostatin receptor ligands (SRLs) inhibited proliferation and lipogenesis in preadipocytes. They achieved this by suppressing the PI3K/Akt pathway and downregulating the expression of PPAR gamma and C/EBP alpha.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Benjarat Janson, Janjira Prasomthong, Wachirawadee Malakul, Tantip Boonsong, Sakara Tunsophon
Summary: This study demonstrated that roselle extract can reduce body weight, food intake, lipid profiles, inflammatory cytokines, lipid peroxidation, serum leptin, insulin, and duodenal glucose absorption, while significantly increasing glucose uptake of adipose tissue and muscle compared to a high-fat diet group. Roselle can prevent lipid accumulation by suppressing differentiation of 3T3-L1 adipocyte through downregulating adipogenic gene expression, providing an alternative approach for preventing obesity-related insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Chul Sang Lee, Mi Hyun Park, Sae Hun Kim
Summary: This study investigated the potential antiobesity characteristics of six lactic acid bacteria strains on mouse preadipocytes. Lactobacillus johnsonii 3121 and Lactobacillus rhamnosus 86 were found to be effective in reducing triglyceride and lipid accumulation, as well as inhibiting adipocyte differentiation by downregulating adipogenic transcription factors. These results suggest that L. johnsonii 3121 and L. rhamnosus 86 could act as probiotic bacteria to prevent fat accumulation by regulating adipogenesis-related markers.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Chemistry, Medicinal
Fernanda Malanconi Thomaz, Jussara de Jesus Simao, Viviane Simoes da Silva, Meira Maria Forcelini Machado, Lila Missae Oyama, Eliane Beraldi Ribeiro, Maria Isabel Cardoso Alonso Vale, Monica Marques Telles
Summary: The study found that Ginkgo biloba extract (GbE) can modulate adipocyte differentiation, increasing lipid content and gene expression of major adipogenesis markers. GbE can modify key proteins involved in the differentiation process and accelerate the expression of mature adipocyte proteins.
Article
Biochemistry & Molecular Biology
Shunsuke Kimura, Ai Tsuruma, Eisuke Kato
Summary: Expression of taste 2 receptor (T2R) genes has been observed in mouse white adipose tissue and 3T3-L1 adipocytes. Fasting and bitter compounds stimulation increases Tas2r expression in mouse white adipose tissue, while serum starvation and bitter compounds stimulation increases Tas2r gene expression in 3T3-L1 adipocytes. Tas2r126 may play a role in adipocyte differentiation, as suggested by RNA sequencing analysis and overexpression studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Juhee Kim, Myoungsook Lee
Summary: Obesity can lead to various complications such as diabetes, hypertension, fatty liver, cardiovascular diseases, and cancer. A pilot study identified the DNAJC6 gene as significantly related to resting metabolic rate (RMR) in childhood obesity. Further investigation revealed that overexpression of DNAJC6 causes a new mechanism in obesity, including suppressed adipogenesis, decreased lipolysis resistance, reduced adipokine expression, disrupted insulin signaling, and impaired mitochondrial functions.
Article
Biochemistry & Molecular Biology
Tae-Jun Park, Anna Park, Jaehoon Kim, Jeong-Yoon Kim, Baek Soo Han, Kyoung-Jin Oh, Eun Woo Lee, Sang Chul Lee, Kwang-Hee Bae, Won Kon Kim
Summary: Obesity is a major health problem linked to metabolic diseases, with adipogenesis being regulated by signals and potentially targeted for obesity prevention through substances like Myonectin.
Article
Cell Biology
Vanessa Castelli, Laura Brandolini, Michele D'Angelo, Cristina Giorgio, Margherita Alfonsetti, Pasquale Cocchiaro, Francesca Lombardi, Annamaria Cimini, Marcello Allegretti
Summary: Type 2 diabetes mellitus is a severe public health issue worldwide, often correlated with obesity. New drugs targeting the inhibition of proinflammatory adipocytokines secretion from adipocytes may be a potential treatment approach for the disease.
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.