HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved

Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs

(2012) Laia Tolosa et al.   TOXICOLOGICAL SCIENCES

An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development

(2010) Melinda Reese et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity

(2010) B.K. Park et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo

(2010) M. T. Donato et al.   DRUG METABOLISM AND DISPOSITION

Enhanced Susceptibility of HLA-mediated Ticlopidine-induced Idiosyncratic Hepatotoxicity by CYP2B6 Polymorphism in Japanese

(2010) Noritaka Ariyoshi et al.   Drug Metabolism and Pharmacokinetics

Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project

(2010) María José Gómez-Lechón et al.   TOXICOLOGY IN VITRO

Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel

(2009) Patrick M. Dansette et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s

(2009) Bo Wen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Simultaneous Expression of Plural Forms of Human Cytochrome P450 at Desired Ratios in HepG2 Cells: Adenovirus-mediated Tool for Cytochrome P450 Reconstitution

(2009) Kazunobu Aoyama et al.   Drug Metabolism and Pharmacokinetics

Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective

(2009) Wei Tang et al.   DRUG METABOLISM REVIEWS

Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

(2009) Craig Lammert et al.   HEPATOLOGY

Development of a High-Throughput Human HepG2 Dual Luciferase Assay for Detection of Metabolically Activated Hepatotoxicants and Genotoxicants

(2009) Xuemei Liu et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and γ-glutamylcysteine synthetase knockdown cells

(2009) Hiroko Hosomi et al.   TOXICOLOGY IN VITRO

In Vitro Screening Techniques for Reactive Metabolites for Minimizing Bioactivation Potential in Drug Discovery

(2008) Chandra Prakash et al.   CURRENT DRUG METABOLISM

Cell Lines: A Tool for In Vitro Drug Metabolism Studies

(2008) M. Gomez-Lechon et al.   CURRENT DRUG METABOLISM