Article
Pharmacology & Pharmacy
Daniel Fernandes, Rayomand S. Khambata, Gianmichele Massimo, Ernesto Ruivo, Lorna C. Gee, Julie Foster, Alison Goddard, Mike Curtis, Michael R. Barnes, William G. Wade, Thomas Godec, Marco Orlandi, Francesco D'Aiuto, Amrita Ahluwalia
Summary: The study found that inorganic nitrate can improve endothelial dysfunction caused by periodontitis by restoring nitrite and nitric oxide levels. In mice experiments, inorganic nitrate reduced vascular wall inflammation and increased levels of anti-inflammatory cytokine interleukin-10, thus reducing tissue oxidative stress. In patients with periodontitis, plasma nitrite levels were not associated with endothelial function. This research highlights the potential of dietary nitrate as an adjunct therapy to improve cardiovascular health outcomes in patients with periodontitis.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Motika Geethika, Namrata Singh, Sagar Kumar, Somanathapura K. Naveen Kumar, Govindasamy Mugesh
Summary: The conversion of nitric oxide (NO) into peroxynitrite (ONOO-) in a superoxide (O-2(.-))-rich environment is a major cause of reduced NO levels in vascular walls, leading to cardiovascular complications. Superoxide dismutase (SOD) mimetics that can selectively catalyze the dismutation of O-2(.-) in the presence of NO are challenging to design but have therapeutic relevance. In this study, the authors show that SOD mimetic cerium vanadate (CeVO4) nanozymes effectively regulate the bioavailability of NO and O-2(.-) even in the absence of cellular SOD enzyme, leading to improved endothelial function and potential applications in biological treatments.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Wenwei Lu, Yusheng Wang, Zhifeng Fang, Hongchao Wang, Jinlin Zhu, Qixiao Zhai, Jianxin Zhao, Hao Zhang, Wei Chen
Summary: This study evaluated the preventive effect of Bifidobacterium longum CCFM752 on hypertension and found that it can prevent hypertension by inhibiting oxidative stress and restoring gut microbiota balance.
Review
Pharmacology & Pharmacy
Shiv Sharma, Swathi Sridhar, Alasdair McIntosh, Claudia-Martina Messow, Eva Munoz Aguilera, Rita Del Pinto, Davide Pietropaoli, Renata Gorska, Mateusz Siedlinski, Pasquale Maffia, Maciej Tomaszewski, Tomasz J. Guzik, Francesco D'Aiuto, Marta Czesnikiewicz-Guzik
Summary: The study compared the effects of intensive periodontal treatment and conventional periodontal treatment on arterial blood pressure, endothelial function, and inflammatory/metabolic biomarkers. The results showed that intensive periodontal treatment improved cardiovascular health in hypertensive and prehypertensive individuals, with no significant effect observed in normotensive individuals.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Zhengyao Cai, Suxin Yuan, Yi Zhong, Li Deng, Jiafu Li, Xiaoqiu Tan, Jian Feng
Summary: Diabetes eventually leads to chronic vascular complications, with TGR5 potentially serving as a novel therapeutic target for diabetes-associated endothelial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Priscila Rezeck Nunes, Sarah Viana Mattioli, Valeria Cristina Sandrim
Summary: Preeclampsia is a specific syndrome of human pregnancy and a leading cause of maternal death. Persistent inflammation in the endothelium activates various signaling pathways, including NLRP3, exacerbating oxidative stress and endothelial dysfunction. Inhibition of NLRP3 activation may offer potential therapeutic solutions for this condition in the future.
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Cardiac & Cardiovascular Systems
Jody L. Greaney, Erika F. H. Saunders, Lacy M. Alexander
Summary: Activation of NF-kappa B, through increased vascular ROS production, contributes to reduced NO-dependent endothelial dilation in young adults with MDD. Short-term treatment with NF-kappa B inhibitor salsalate improves NO-mediated endothelium-dependent dilation in MDD patients, while acute localized ROS scavenging with apocynin enhances NO-dependent dilation before salsalate administration.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Barbara Terroni, Luis Henrique Oliveira de Moraes, Aline Renata Pavan, Gerson Jhonatan Rodrigues, Jean Leandro Dos Santos
Summary: The study found that Lapdesf-4c can induce vasodilation and counteract endothelial dysfunction, showing great potential as a new drug candidate.
Article
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: TMAO may be involved in impairing the endothelial-dependent vasodilatory mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Zheyi Yan, Xiaoming Cao, Chunfang Wang, Sha Liu, Yanjie Li, Gan Lu, Wenjun Yan, Rui Guo, Dajun Zhao, Jimin Cao, Yong Xu
Summary: CTRP3 improves vasodilation of microvasculature in diabetes by enhancing endothelial cell function through the AMPK/eNOS/NO. signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Mara Paneroni, Evasio Pasini, Michele Vitacca, Simonetta Scalvini, Laura Comini, Anna Pedrinolla, Massimo Venturelli
Summary: The study revealed that COVID-19 infection significantly impacted blood velocity and femoral blood flow in patients, which may contribute to fatigue, changes in muscle metabolism, and increased cardiovascular risk in long COVID-19 syndrome. Further evaluation is needed to assess the impact of specific treatments such as exercise training, dietary supplements, or drugs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Doaa R. R. Adam, Manal M. M. Alem
Summary: Erectile dysfunction is a global public health concern associated with cardiovascular risk factors, and is considered a clinical marker for future adverse events.
Article
Surgery
Regina Sordi, Fausto Chiazza, Debora Collotta, Giuseppe Migliaretti, Romain A. Colas, Paul Vulliamy, Karim Brohi, Jesmond Dalli, Massimo Collino, Christoph Thiemermann
Summary: The study found that trauma results in a significant reduction in plasma levels of resolvin D1 in patients. In rat experiments, RvD1 has a protective effect on organ damage and dysfunction caused by hemorrhagic shock.
Article
Pharmacology & Pharmacy
Regina Sordi, Angela Cristina Bet, Ana Maria Della Justina, Gustavo Campos Ramos, Jamil Assreuy
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Caroline Bello, Ana Paula Prestes, Josiane Aparecida Schemberger, Ana Carolina Mendes Hacke, Romaiana Picada Pereira, Francine Alessandra Manente, Iracilda Zeppone Carlos, Cleverton Roberto de Andrade, Daniel Fernandes, Ivana Beatrice Manica da Cruz, Tais Cristina Unfer, Jose Carlos Rebuglio Vellosa
Summary: The study demonstrated that the aqueous extract of Paullinia cupana showed antioxidant activity and protected tissues from damage caused by ketoprofen. Co-administration of AEG reversed alterations in biochemical parameters and restored white blood cell count decreased by ketoprofen. The association between ketoprofen and AEG may be an alternative to reduce health damages caused by this drug.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Medicinal
Bruno Rodrigo Minozzo, Evelyn Assis de Andrade, Jose Carlos Rebuglio Vellosa, Leandro Cavalcante Lipinski, Daniel Fernandes, Geisson Marcos Nardi, Ricardo Pereira Rodrigues, Rodrigo Rezende Kitagawa, Corine Girard, Celine Demougeot, Flavio Luis Beltrame
Summary: Euphorbia umbellata bark extracts and its compounds have the potential to improve endothelial dysfunction by inhibiting vascular ARG activity, as shown through various in vitro and in vivo experiments.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Daniel Fernandes, Leticia Kramer Pacheco, Regina Sordi, Karin Scheschowitsch, Gustavo Campos Ramos, Jamil Assreuy
Summary: A study found that early and partial blockade of the AT 1 receptor with a low dose of losartan can counteract sepsis-induced refractoriness to vasoconstrictors, providing an opportunity to improve the outcome of this condition.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lorna C. Gee, Gianmichele Massimo, Clement Lau, Christopher Primus, Daniel Fernandes, Jianmin Chen, Krishnaraj S. Rathod, Alexander J. P. Hamers, Federica Filomena, Gani Nuredini, Abdiwahab Shidane Ibrahim, Rayomand S. Khambata, Ajay K. Gupta, James C. Moon, Vikas Kapil, Amrita Ahluwalia
Summary: The study found that patients with cardiac hypertrophy and fibrosis had lower plasma nitrite concentrations and vascular dysfunction. Dietary nitrate was shown to improve cardiac remodelling by targeting endothelial dysfunction and reducing cardiac fibrosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Gustavo Ferreira Alves, Eleonora Aimaretti, Giacomo Einaudi, Raffaella Mastrocola, Junior Garcia de Oliveira, Debora Collotta, Elisa Porchietto, Manuela Aragno, Carlo Cifani, Regina Sordi, Christoph Thiemermann, Daniel Fernandes, Massimo Collino
Summary: Sepsis and septic shock are serious public health concerns with high mortality rates. This study investigates the role of two non-receptor protein tyrosine kinases, FAK and Pyk2, in sepsis-induced inflammation and the potential benefits of modulating this pathway with the drug PF271. The findings suggest that FAK-Pyk2 contributes to sepsis-induced organ injury and dysfunction, and targeting this pathway could be a new strategy for treating sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Filipe Rodolfo Moreira Borges Oliveira, Jamil Assreuy, Regina Sordi
Summary: Sepsis is a major cause of acute kidney injury (AKI), involving mechanisms such as oxidative stress and endothelial dysfunction. Nitric oxide (NO) is an important element in these mechanisms. The different isoforms of nitric oxide synthase (NOS) contribute differently to nitrergic signaling in the kidneys. While endothelial and neuronal isoforms are important under basal conditions, the inducible isoform (iNOS) is significantly increased during sepsis. Inhibiting iNOS selectively without affecting other isoforms is ideal, but iNOS also plays a role in immune defense, so targeting NO effectors may be a more interesting approach.
BIOSCIENCE REPORTS
(2022)
Article
Immunology
Gustavo Ferreira Alves, Ian Stoppa, Eleonora Aimaretti, Chiara Monge, Raffaella Mastrocola, Elisa Porchietto, Giacomo Einaudi, Debora Collotta, Ilaria Bertocchi, Elena Boggio, Casimiro Luca Gigliotti, Nausicaa Clemente, Manuela Aragno, Daniel Fernandes, Carlo Cifani, Christoph Thiemermann, Chiara Dianzani, Umberto Dianzani, Massimo Collino
Summary: ICOS-Fc can act as an immunomodulatory drug to protect against sepsis by modulating cytokine release and cell migration, reducing inflammation and organ damage.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Lucas Braga Albino, Regina Sordi, Junior Garcia de Oliveira, Daniel Fernandes
Summary: Adenosine is a vital regulator in the cardiovascular system that affects various processes through G protein-coupled receptors. Caffeine, a widely used pharmacological tool, blocks adenosine receptors and can reverse its cardiovascular effects. This study evaluated the dose and duration of caffeine needed to block adenosine-induced cardiovascular changes in rats. The results showed that a dose of 30 mg/kg of caffeine effectively blocked adenosine-induced events for up to 4 hours, providing valuable information for future studies.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Daniel Fernandes, Rayomand S. Khambata, Gianmichele Massimo, Ernesto Ruivo, Lorna C. Gee, Julie Foster, Alison Goddard, Mike Curtis, Michael R. Barnes, William G. Wade, Thomas Godec, Marco Orlandi, Francesco D'Aiuto, Amrita Ahluwalia
Summary: The study found that inorganic nitrate can improve endothelial dysfunction caused by periodontitis by restoring nitrite and nitric oxide levels. In mice experiments, inorganic nitrate reduced vascular wall inflammation and increased levels of anti-inflammatory cytokine interleukin-10, thus reducing tissue oxidative stress. In patients with periodontitis, plasma nitrite levels were not associated with endothelial function. This research highlights the potential of dietary nitrate as an adjunct therapy to improve cardiovascular health outcomes in patients with periodontitis.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Tayline Mroczek, Gabrielle Delfrate, Leomar Emanuel Almeida Mecca, Jessica Daniela Andreis, Leandro Cavalcante Lipinski, Daniel Fernandes, Michelle da Campos Soriani Azevedo, Jessica Lima Melchiades, Gustavo Pompermaier Garlet, Gilson Cesar Nobre Franco, Marcela Claudino
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Public, Environmental & Occupational Health
Nathalia Rodrigues Bulka, Ana Carolina Mendes Hacke, Valeria Gremski Pawlak, Romaiana Picada Pereira, Luis Antonio Esmerino, Jose Carlos Rebuglio Vellosa
ACTA SCIENTIARUM-HEALTH SCIENCES
(2020)
Article
Dentistry, Oral Surgery & Medicine
Engku Nasiha Engku Ngah Sayuddin, Muhammad Taher, Mohd Hafiz Arzmi, Nor Aszlitah Burhanudin, Muhamad Ashraf Rostam
Summary: This article reviews the role of podoplanin in oral cancer and its potential as a therapeutic agent. High expression of podoplanin has been observed in oral cancer and pre-cancerous lesions, suggesting that inhibitors targeting podoplanin could be effective in treating oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Doris Haydee Rosero Salazar, Sydney Honnlee, Zi-Jun Liu
Summary: This study analyzed the dynamics and coordination of oropharyngeal muscles during natural chewing and swallowing, revealing the key role of palatal and pharyngeal muscles in chewing and the simultaneous changes in muscle activity and respiratory cycle during these processes.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Junkang Quan, Yang Liu, Lingli Ji, Yuming Zhao, Shuguo Zheng
Summary: This study identified a new DLX3 gene mutation in a Chinese family with enamel dysplasia and found that this mutation may affect ameloblast differentiation by inhibiting the transcriptional activity of Amelx/Odam/Klk4, thereby interfering with enamel formation.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Viviane Martins dos Santos Ribeiro, Mauricio Gonsalves da Costa Sousa, Paula Ribeiro Garcia, Lucas Souza dos Santos, Eliza Carla Barroso Duarte, Jose Raimundo Correa, Carlos Alberto Labate, Thais Regiani Cataldi, Rosiane Andrade da Costa, Marcelo Henrique Soller Ramada, Juliana Lott de Carvalho, Taia Maria Berto Rezende
Summary: This study compared the structural and proteomic architecture of decellularized human dental pulp using two different protocols. The results showed that the ECM preserved in the MG protocol was more intact. Proteomic analysis revealed that the MG protocol maintained around 69.56% of the proteins identified in the untreated pulp tissue, while the SG protocol only maintained 28.26%.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Jinjin Lu, Lixin Zhang, Ningxin Zhu, Dan Wang, Fei Xie, Man Qin, Yuanyuan Wang
Summary: The study investigated the effects of varying glucose concentrations on the proliferation and senescence of SHED and hBMSC. It was found that high glucose levels promoted proliferation in both cell types, but delayed senescence in SHED through autophagy inhibition and accelerated senescence in hBMSC. Additionally, the glycolysis in SHED was enhanced under high glucose culture conditions compared to hBMSC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Luciana O. Almeida, Luan Cesar Silva, Carolina Emerick, Juliana Amorim dos Santos, Rogerio M. Castilho, Cristiane H. Squarize
Summary: This study found that the loss of PTEN signaling increases the population of HNSCC CSCs, which can be targeted by rapamycin. However, a deficiency in mTORC2 can lead to problematic selection of the parasphere CSC subtype.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Elham Mohebbi, Zainab Alimoradi, Laura S. Rozek, Azadeh Mohebbi, Elahe Jafari
Summary: This study conducted a systematic review and meta-analysis to investigate the risk of head and neck cancer among opium users. The findings showed a significant correlation between opium use and the development of head and neck cancers, particularly lip and oral cavity cancers and laryngeal cancer. This highlights the importance of further research and targeted preventive measures to address this concerning association.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Antonio Alexandre Coelho, Rute Romao Carvalho, Ana Luiza Muniz, Andre Alves Crispim, Anderson Maia Meneses, Carla Welch da Silva, Dayrine Silveira de Paula, Ana Paula Negreiros Nunes Alves, Fabricio Bitu Sousa, Paulo Goberlanio de Barros Silva
Summary: The study aimed to evaluate the role of CD20 + cells in the healing process of oral traumatic ulcers (OTU) in rats. The results showed that blocking CD20 + cells with anti-CD20 rituximab (RTX) reduced cell migration, acute inflammation, and wound healing in OTU.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Meimei Cui, Jinling Cheng, Huijuan Cheng, Ming Zhao, Dan Zhou, Min Zhang, Jingjing Jia, Limei Luo
Summary: This study explored the characteristics of human papillomavirus (HPV) in oropharyngeal carcinoma (OPC) and found that high-risk HPV infection is common in OPC patients, with higher prevalence in North America, Oceania, and Europe. Females and older patients are more susceptible to infection. Tonsil and base of tongue are the most frequent sites of infection. This study provides important theoretical basis for the prevention and treatment of OPC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyue Guan, Chen Shi, Yuting Wang, Yani He, Yingxue Li, Yao Yang, Wenli Mu, Wenlan Li, Tiezhou Hou
Summary: The study revealed that Gremlin1 expression levels are significantly increased in periapical lesions and may be positively correlated with IL-18 levels. Blocking Gremlin1 can significantly suppress bone resorption loss and restrain inflammatory status by affecting the activation levels of phosphorylated-CREB, ICAM-1, VCAM-1, IL-18.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Giliano Nicolini Verzeletti, Eduardo Jose Gaio, Keilla Gomes Machado, Tobias Rauber Spuldaro, Clarissa Favero Demeda, Rafaele Frassini, Andre Felipe Streck, Sidnei Moura E. Silva, Cassiano Kuchenbecker Rosing, Joao Antonio Pegas Henriques, Mariana Roesch-Ely
Summary: This study investigates the effects of D. anceps seaweed on ligature-induced experimental periodontitis in rats. The results show that D. anceps can modulate the inflammatory response and have potential therapeutic effects for periodontitis.
ARCHIVES OF ORAL BIOLOGY
(2024)
