To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease

Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches

(2020) Jess D. Hebert et al.   CANCER RESEARCH

The stiffness of living tissues and its implications for tissue engineering

(2020) Carlos F. Guimarães et al.   Nature Reviews Materials

Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation

(2020) Fabiana Cerqueira Campos et al.   DEVELOPMENT

The extracellular matrix in development

(2020) David A. Cruz Walma et al.   DEVELOPMENT

Corneal epithelial basement membrane: Structure, function and regeneration

(2020) Steven E. Wilson et al.   EXPERIMENTAL EYE RESEARCH

Basement membrane remodelling regulates mouse embryogenesis

(2020) Christos Kyprianou et al.   NATURE

Synthetic alternatives to Matrigel

(2020) Elizabeth A. Aisenbrey et al.   Nature Reviews Materials

Integrins Modulate Extracellular Matrix Organization to Control Cell Signaling during Hematopoiesis

(2020) Rohan J. Khadilkar et al.   CURRENT BIOLOGY

Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding

(2020) Daniel P. Keeley et al.   DEVELOPMENTAL CELL

Rapid Homeostatic Turnover of Embryonic ECM during Tissue Morphogenesis

(2020) Yutaka Matsubayashi et al.   DEVELOPMENTAL CELL

High-sensitivity and high-specificity biomechanical imaging by stimulated Brillouin scattering microscopy

(2020) Itay Remer et al.   NATURE METHODS

Environmentally controlled magnetic nano-tweezer for living cells and extracellular matrices

(2020) Christian Aermes et al.   Scientific Reports

Mechanics of a multilayer epithelium instruct tumour architecture and function

(2020) Vincent F. Fiore et al.   NATURE

Epithelial organ shape is generated by patterned actomyosin contractility and maintained by the extracellular matrix

(2020) Ali Nematbakhsh et al.   PLoS Computational Biology

Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs

(2019) Laura C. Kelley et al.   DEVELOPMENTAL CELL

Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress

(2019) Maria Duda et al.   DEVELOPMENTAL CELL

Physical and functional cell-matrix uncoupling in a developing tissue under tension

(2019) Amsha Proag et al.   DEVELOPMENT

Stress relaxation in epithelial monolayers is controlled by the actomyosin cortex

(2019) Nargess Khalilgharibi et al.   Nature Physics

Engineering Stem Cell Self-organization to Build Better Organoids

(2019) Jonathan A. Brassard et al.   Cell Stem Cell

Beyond proteases: Basement membrane mechanics and cancer invasion

(2019) Julie Chang et al.   JOURNAL OF CELL BIOLOGY

Covalent cross-linking of basement membrane-like matrices physically restricts invasive protrusions in breast cancer cells

(2019) Katrina M. Wisdom et al.   MATRIX BIOLOGY

Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation

(2019) Dong-Yuan Chen et al.   Nature Communications

Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility

(2019) Ryan S. Stowers et al.   Nature Biomedical Engineering

Brillouin microscopy: an emerging tool for mechanobiology

(2019) Robert Prevedel et al.   NATURE METHODS

Planar Differential Growth Rates Initiate Precise Fold Positions in Complex Epithelia

(2019) Melda Tozluoǧlu et al.   DEVELOPMENTAL CELL

Laminin 332 in cancer: When the extracellular matrix turns signals from cell anchorage to cell movement

(2019) Patricia Rousselle et al.   SEMINARS IN CANCER BIOLOGY

Photopolymerized dynamic hydrogels with tunable viscoelastic properties through thioester exchange

(2018) Tobin E. Brown et al.   BIOMATERIALS

TheDrosophilaHox geneUltrabithoraxcontrols appendage shape by regulating extracellular matrix dynamics

(2018) José M. De las Heras et al.   DEVELOPMENT

Apical and Basal Matrix Remodeling Control Epithelial Morphogenesis

(2018) Maria-del-Carmen Diaz-de-la-Loza et al.   DEVELOPMENTAL CELL

Basement membrane mechanics shape development: Lessons from the fly

(2018) William Ramos-Lewis et al.   MATRIX BIOLOGY

A scar-like lesion is apparent in basement membrane after wound repair in vivo

(2018) William Ramos-Lewis et al.   MATRIX BIOLOGY

Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging

(2018) Raimund Schlüßler et al.   BIOPHYSICAL JOURNAL

Nanoscale topography and poroelastic properties of model tissue breast gland basement membranes

(2018) G. Fabris et al.   BIOPHYSICAL JOURNAL

Bi-directional cell-pericellular matrix interactions direct stem cell fate

(2018) Silvia A. Ferreira et al.   Nature Communications

Dissection of Nidogen function in Drosophila reveals tissue-specific mechanisms of basement membrane assembly

(2018) Jianli Dai et al.   PLoS Genetics

Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier

(2018) Laura Cristina Ceafalan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Forces drive basement membrane invasion inCaenorhabditis elegans

(2018) Rodrigo Cáceres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential lateral and basal tension drive folding of Drosophila wing discs through two distinct mechanisms

(2018) Liyuan Sui et al.   Nature Communications

Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments

(2018) Katrina M. Wisdom et al.   Nature Communications

Basement membranes and autoimmune diseases

(2017) Mary H. Foster   MATRIX BIOLOGY

Cell therapy for basement membrane-linked diseases

(2017) Alexander Nyström et al.   MATRIX BIOLOGY

The nature and biology of basement membranes

(2017) Ambra Pozzi et al.   MATRIX BIOLOGY

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Diabetes-related changes in the protein composition and the biomechanical properties of human retinal vascular basement membranes

(2017) Willi Halfter et al.   PLoS One

Laminin Levels Regulate Tissue Migration and Anterior-Posterior Polarity during Egg Morphogenesis in Drosophila

(2017) María C. Díaz de la Loza et al.   Cell Reports

Organ sculpting by patterned extracellular matrix stiffness

(2017) Justin Crest et al.   eLife

The interplay of stiffness and force anisotropies drives embryo elongation

(2017) Thanh Thi Kim Vuong-Brender et al.   eLife

Restoration of the basement membrane after wounding: a hallmark of young human skin altered with aging

(2017) Gary Fisher et al.   Journal of Cell Communication and Signaling

Viscoplasticity Enables Mechanical Remodeling of Matrix by Cells

(2016) Sungmin Nam et al.   BIOPHYSICAL JOURNAL

A question of time: tissue adaptation to mechanical forces

(2016) Tom Wyatt et al.   CURRENT OPINION IN CELL BIOLOGY

The dynamic mechanical properties of cellularised aggregates

(2016) Nargess Khalilgharibi et al.   CURRENT OPINION IN CELL BIOLOGY

Rab10-Mediated Secretion Synergizes with Tissue Movement to Build a Polarized Basement Membrane Architecture for Organ Morphogenesis

(2016) Adam J. Isabella et al.   DEVELOPMENTAL CELL

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

A Mutation in fat2 Uncouples Tissue Elongation from Global Tissue Rotation

(2016) Franziska Aurich et al.   Cell Reports

Mammary gland development: cell fate specification, stem cells and the microenvironment

(2015) J. L. Inman et al.   DEVELOPMENT

Dynamic regulation of basement membrane protein levels promotes egg chamber elongation in Drosophila

(2015) Adam J. Isabella et al.   DEVELOPMENTAL BIOLOGY

An active role for basement membrane assembly and modification in tissue sculpting

(2015) M. A. Morrissey et al.   JOURNAL OF CELL SCIENCE

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture

(2014) A. Scott McCall et al.   CELL

Local and global dynamics of the basement membrane during branching morphogenesis require protease activity and actomyosin contractility

(2014) Jill S. Harunaga et al.   DEVELOPMENTAL BIOLOGY

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

(2014) Boon Chuan Low et al.   FEBS LETTERS

The Drosophila Egg Chamber--A New Spin on How Tissues Elongate

(2014) S. Horne-Badovinac   INTEGRATIVE AND COMPARATIVE BIOLOGY

AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival

(2014) Mercedes Rodriguez-Teja et al.   JOURNAL OF PATHOLOGY

Proteomic Analysis of Altered Extracellular Matrix Turnover in Bleomycin-induced Pulmonary Fibrosis

(2014) Martin L. Decaris et al.   MOLECULAR & CELLULAR PROTEOMICS

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation

(2014) Maureen Cetera et al.   Nature Communications

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

(2014) Alexandra Naba et al.   eLife

From tissue mechanics to transcription factors

(2013) Paul A. Janmey et al.   DIFFERENTIATION

Diabetes-induced morphological, biomechanical, and compositional changes in ocular basement membranes

(2013) Margaret To et al.   EXPERIMENTAL EYE RESEARCH

Misshapen decreases integrin levels to promote epithelial motility and planar polarity inDrosophila

(2013) Lindsay Lewellyn et al.   JOURNAL OF CELL BIOLOGY

The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo

(2013) Elliott J. Hagedorn et al.   JOURNAL OF CELL BIOLOGY

Generating suspended cell monolayers for mechanobiological studies

(2013) Andrew R Harris et al.   Nature Protocols

The Bi-Functional Organization of Human Basement Membranes

(2013) Willi Halfter et al.   PLoS One

Functional Diversity of Laminins

(2012) Anna Domogatskaya et al.   Annual Review of Cell and Developmental Biology

The Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc

(2012) L. Sui et al.   DEVELOPMENT

Elastic Characterization of Transversely Isotropic Soft Materials by Dynamic Shear and Asymmetric Indentation

(2012) R. Namani   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

The evolution of metazoan extracellular matrix

(2012) Richard O. Hynes   JOURNAL OF CELL BIOLOGY

A secreted MMP is required for reepithelialization during wound healing

(2012) Laura J. Stevens et al.   MOLECULAR BIOLOGY OF THE CELL

Alport syndrome—insights from basic and clinical research

(2012) Jenny Kruegel et al.   Nature Reviews Nephrology

Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly

(2012) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From macro- to microscale poroelastic characterization of polymeric hydrogels via indentation

(2012) Z. Ilke Kalcioglu et al.   Soft Matter

Shaping Cells and Organs in Drosophila by Opposing Roles of Fat Body-Secreted Collagen IV and Perlecan

(2011) José Carlos Pastor-Pareja et al.   DEVELOPMENTAL CELL

Global Tissue Revolutions in a Morphogenetic Movement Controlling Elongation

(2011) S. L. Haigo et al.   SCIENCE

Extracellular Matrix in Development: Insights from Mechanisms Conserved between Invertebrates and Vertebrates

(2011) N. H. Brown   Cold Spring Harbor Perspectives in Biology

Biophysical properties of normal and diseased renal glomeruli

(2010) Hans M. Wyss et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Using indentation to characterize the poroelasticity of gels

(2010) Yuhang Hu et al.   APPLIED PHYSICS LETTERS

Stress-relaxation behavior in gels with ionic and covalent crosslinks

(2010) Xuanhe Zhao et al.   JOURNAL OF APPLIED PHYSICS

The keratin-filament cycle of assembly and disassembly

(2010) A. Kolsch et al.   JOURNAL OF CELL SCIENCE

Age-dependent changes in the structure, composition and biophysical properties of a human basement membrane

(2010) Joseph Candiello et al.   MATRIX BIOLOGY

Wound Healing Primer

(2010) Stephanie R. Goldberg et al.   SURGICAL CLINICS OF NORTH AMERICA

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Basement Membranes: Cell Scaffoldings and Signaling Platforms

(2010) P. D. Yurchenco   Cold Spring Harbor Perspectives in Biology

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Possible Involvement of Basement Membrane Damage in Skin Photoaging

(2009) Satoshi Amano   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Origin and turnover of ECM proteins from the inner limiting membrane and vitreous body

(2008) W Halfter et al.   EYE

Mammalian collagen IV

(2008) Jamshid Khoshnoodi et al.   MICROSCOPY RESEARCH AND TECHNIQUE