Article
Polymer Science
Feng Chen, Shaochun Gu, Qianming Zhang, Tong Liu, Zhenjie Liu, Tairong Kuang
Summary: The microstructure design of hydrogel materials offers a broad range of practical applications in various biomedical engineering fields. This study compared the photolithography and light-cured inkjet printing methods for methacryloyl HA hydrogel (HAMA-gel) to those for synthetic light-curable polymer resins. The results showed that both methods were effective in preparing well-shaped micropatterns of HAMA-gel with high resolution and little processing time. HAMA-gel also demonstrated good biocompatibility.
Article
Engineering, Electrical & Electronic
Wei Chang, Chien-Ping Wang, Yao-Hung Huang, Burn Jeng Lin, Pin-Jiun Wu, Jiaw-Ren Shih, Yue-Der Chih, Jonathan Chang, Chrong Jung Lin, Ya-Chin King
Summary: A 4K detector array for on-wafer extreme ultraviolet (EUV) imaging is demonstrated. It is compatible with FinFET CMOS logic, features a compact 1T pixel and high spatial resolution, and operates without a battery. The stored sensed signal can be accessed through nondestructive wafer-level tests. It provides in-tool monitoring of critical parameters in advanced lithographical systems.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Multidisciplinary Sciences
Kyung Oh Jung, Ashok Joseph Theruvath, Hossein Nejadnik, Anna Liu, Lei Xing, Todd Sulchek, Heike E. Daldrup-Link, Guillem Pratx
Summary: Regenerative medicine uses patient own stem cells to regenerate damaged tissues. This study presents a rapid, effective, and straightforward method for cell labeling using mechanoporation. The labeled cells can be monitored post-implantation using PET imaging.
SCIENTIFIC REPORTS
(2022)
Review
Polymer Science
Hidenori Otsuka
Summary: Advances in cellular micropatterning have led to the development of cell-based biosensors and revolutionized drug screening. Microfabricated synthetic surfaces can regulate the cellular environment and be used for tissue regeneration. This review focuses on surface engineering techniques for the cellular micropatterning of 3D spheroids.
Article
Materials Science, Multidisciplinary
Gustavo Adolfo Gonzalez Flores, Valentina Bertana, Annalisa Chiappone, Ignazio Roppolo, Luciano Scaltrito, Simone Luigi Marasso, Matteo Cocuzza, Giulia Massaglia, Marzia Quaglio, Candido Fabrizio Pirri, Sergio Ferrero
Summary: This work discusses the fabrication of silver-patterned polymeric devices using a customized resin and 3D printing technology. Utilizing a customized SL-3D printer, it is possible to selectively generate silver nanoparticles by adjusting laser settings, allowing for the creation of silver-patterned surfaces using the same light source and printable resin.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Joao Serra, Sara Sequeira, Ismael Domingos, Ana Paracana, Ermelinda Macoas, Luis V. Melo, Bernardo J. Pires, Susana Cardoso, Diana C. Leitao, Helena Alves
Summary: Light detection technologies play a crucial role in energy conversion and optical communications. Single-crystal organic semiconductors, like rubrene, have high detectivities and charge carrier mobility, making them appealing for light-sensing applications. The fabrication of patterned micrometric rubrene photosensors using photolithography and Reactive Ion Etching steps shows promise for industrial-scale production of high-performance optoelectronic devices.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Zhuo Liu, Yang Zhou, Xuecheng Qu, Lingling Xu, Yang Zou, Yizhu Shan, Jiawei Shao, Chan Wang, Ying Liu, Jiangtao Xue, Dongjie Jiang, Yubo Fan, Zhou Li, Haifeng Ye
Summary: The study proposes a self-powered optogenetic system for implantable blood glucose control. This system can harvest energy from body movement and effectively regulate blood glucose homeostasis in treating diabetes.
Article
Nanoscience & Nanotechnology
Xiangqiong He, Pengbao Shi, Taixia Wu, Bing Yu, Hailin Cong, Youqing Shen
Summary: Transmission through the respiratory tract is an important route for bacteria and viruses to infect humans. Researchers have developed polytetrahydropyrimidine-polyethylene terephthalate functional fibers with highly sustained antibacterial and antiviral properties. These fibers effectively kill bacteria and lentiviruses, have no cytotoxicity, and are compatible with cells. By incorporating these fibers into masks, a new type of mask with adsorption, filtration, and killing properties against pathogens was prepared.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Physics, Multidisciplinary
Sandra Perez-Dominguez, Elisabeth Werkmeister, Maria Luisa Marini, Vincent Dupres, Sebastien Janel, Frank Lafont, Manfred Radmacher
Summary: This study investigates the mechanical behavior of fibroblasts under circular geometrical constraints and finds that cell mechanics are influenced by the constraints, potentially leading to pathological conditions. Scar and Dupuytren fibroblasts show a greater ability to adapt to physical changes in the environment compared to control fibroblasts. Micropatterning combined with AFM measurements provides a powerful tool to study cell mechanics in both healthy and pathological states, mimicking aspects of the tissue environment.
FRONTIERS IN PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Hanleem Lee, Ji Won Jeong, Mo Geun So, Gun Young Jung, Chang-Lyoul Lee
Summary: By controlling the ligand-binding kinetics, this work prevents surface defects in perovskite quantum dots, leading to an increase in photoluminescence quantum yield and improved environmental stability. The resulting cross-linked perovskite quantum dot film shows enhanced chemical stability without compromising optoelectrical properties, enabling the successful fabrication of high-resolution white electroluminescent devices by inkjet printing using green and red perovskite quantum dots.
ADVANCED MATERIALS
(2021)
Article
Biology
Kyoung Jo, Seth Teague, Bohan Chen, Hina Aftab Khan, Emily Freeburne, Hunter Li, Bolin Li, Ran Ran, Jason R. Spence, Idse Heemskerk
Summary: In this study, micropatterned human pluripotent stem cells (hPSCs) treated with BMP4 were used as a model to study hPGC specification, and the important role of Nodal signaling in this process was identified. Additionally, a mathematical model was developed to predict fate patterns after signaling perturbations, and it was found that the size of hPSC colonies affects the efficiency of hPGCLC specification.
Article
Engineering, Environmental
Yue Feng, Xiang Luo, Fan Wu, Hongzhong Liu, Enyu Liang, Rong-Rong He, Mingxian Liu
Summary: This study reveals the mechanisms by which halloysite nanotubes accelerate hemostasis through various approaches, including water absorption, blood concentration, triggering intrinsic coagulation cascades, and accelerating clot formation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Gastroenterology & Hepatology
Yang Yuan, Kristen Cotton, Dinithi Samarasekera, Salman R. Khetani
Summary: Liver diseases have a significant impact on global mortality and morbidity, but the use of animal models is limited by species-specific differences. Human liver cells derived from induced pluripotent stem cells offer an abundant resource, but current protocols yield immature phenotypes. Advanced techniques, such as protein micropatterning and 3-dimensional bioprinting, can enhance the maturation of these cells. Continued advancements in stem cell-derived liver models can provide human-relevant data earlier in drug development, aid in understanding liver disease mechanisms, and serve as cell-based therapies for end-stage liver failure patients.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biophysics
Jun'ya Tsutsumi, Anthony P. F. Turner, Wing Cheung Mak
Summary: A new GPS method for coupling biomolecules onto microelectrodes has been developed, enabling high-resolution protein self-patterning. This versatile method can be used for micropatterning various biomolecules such as enzymes, antibodies, and avidin-biotinylated proteins.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Physical
Sang-Kon Kim
Summary: Control of defects in EUV masks using pellicles is challenging due to the stricter fabrication requirements. This study presents the limitations and shear locking issues in commercial finite element methods, and proposes a Python program-based analytical-numerical approach with deep learning as an alternative.
Review
Cell Biology
Sascha Berlansky, Matthias Sallinger, Herwig Grabmayr, Christina Humer, Andreas Bernhard, Marc Fahrner, Irene Frischauf
Summary: This article provides insights into SARS-CoV-2 and COVID-19, discussing vaccine-related issues, breakthrough infections, and the threat of immune escape variants. Additionally, it highlights the important role of calcium signaling in viral infections and explores treatment strategies that exploit the virus's dependence on calcium signals.
Article
Chemistry, Inorganic & Nuclear
Lukasz Wegrzynski, Tomasz Fok, Miroslaw Szczurek, Andrzej Bartnik, Przemyslaw Wachulak, Karol Adam Janulewicz, Chul Min Kim
Summary: The advent of very intense, short-pulse lasers has had a profound impact on the field of laser-matter interaction. By studying medium formed by a combination of large and small gas clusters, the specific properties of this medium and its suitability for intense laser-matter interaction have been demonstrated. These large clusters also enable experiments with single-cluster targets.
JOURNAL OF CLUSTER SCIENCE
(2023)
Review
Cell Biology
Christina Humer, Sascha Berlansky, Herwig Grabmayr, Matthias Sallinger, Andreas Bernhard, Marc Fahrner, Irene Frischauf
Summary: Calcium ion channels play a crucial role in human life, regulating various cellular functions. CRAC channels are the most well-characterised store-operated channels, and their correct function is essential for cellular activities. Disruption of the mechanisms of calcium entry through CRAC channels can lead to health issues and is associated with cancer development.
Article
Optics
Matthias J. Grotevent, Sergii Yakunin, Dominik Bachmann, Carolina Romero, Javier R. Vazquez de Aldana, Matteo Madi, Michel Calame, Maksym Kovalenko, Ivan Shorubalko
Summary: This paper demonstrates a Fourier-transform waveguide spectrometer using HgTe-quantum-dot-based photoconductors, with a spectral response up to 2 μm and a spectral resolution of 50 cm(-1). The small size of the spectrometer enables its integration into consumer electronics and space devices.
Article
Physics, Fluids & Plasmas
Andrzej Bartnik, Karol Jach, Robert Swierczynski, Mateusz Majszyk, Tomasz Fok, Lukasz Wegrzynski, Przemyslaw Wachulak, Henryk Fiedorowicz
Summary: In this work, the time evolution of plasmas generated by the interaction of laser pulses with nitrogen gas was investigated. High-temperature plasmas produced by the laser pulses were found to be a source of soft x-rays and charged particles, which ionized and excited the surrounding gas, leading to the formation of low-temperature plasmas. The formation of low-temperature plasmas was found to be dominated by ion streams or soft x-ray radiation, depending on the distance from the focal spot.
PHYSICS OF PLASMAS
(2022)
Article
Chemistry, Physical
Joanna Czwartos, Angelika Zaszczynska, Agata Nowak-Stepniowska, Tomasz Fok, Boguslaw Budner, Andrzej Bartnik, Przemyslaw Wachulak, Dorota Kolbuk, Pawel Sajkiewicz, Henryk Fiedorowicz
Summary: In this study, a novel method of physicochemical modification and bioactivity enhancement of electrospun fibrous polycaprolactone (PCL) nanofibers using soft X-ray/extreme ultraviolet (SXR/EUV) irradiation and low-temperature plasma treatment was reported. The modified PCL nanofibers showed cyto-compatible and non-cytotoxic properties, as well as enhanced cell adhesion and proliferation.
APPLIED SURFACE SCIENCE
(2022)
Review
Neurosciences
Matthias Sallinger, Herwig Grabmayr, Christina Humer, Daniel Bonhenry, Christoph Romanin, Rainer Schindl, Isabella Derler
Summary: STIM proteins are ER-transmembrane proteins that act as Ca2+ sensors and interact with Orai proteins to activate the CRAC channel. The activation of STIM requires the depletion of ER Ca2+ store, and the conformational dynamics of STIM are associated with disease.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemistry & Molecular Biology
Ferdinand Horvath, Sascha Berlansky, Lena Maltan, Herwig Grabmayr, Marc Fahrner, Isabella Derler, Christoph Romanin, Thomas Renger, Heinrich Krobath
Summary: STIM1 is a protein located in the endoplasmic reticulum (ER) membrane that senses the concentration of calcium ions and plays a role in the activation of calcium channels. Through molecular docking simulations, a structural model of the resting state of STIM1 was established, and the binding interface was analyzed using molecular dynamics simulations. Experimental results confirmed the validity of the model and provided insights into the conformational dynamics of the resting state of STIM1.
Editorial Material
Chemistry, Multidisciplinary
Johannes Heitz
Editorial Material
Cell Biology
Isabella Derler, Christoph Romanin
Article
Chemistry, Physical
Dominic Guggisberg, Sergii Yakunin, Christoph Neff, Marcel Aebli, Detlef Gunther, Maksym V. Kovalenko, Dmitry N. Dirin
Summary: Lead halide perovskite nanocrystals are highly attractive as light-emitting materials due to their excellent properties. In this work, we demonstrate a new method to enhance the stability of these nanocrystals by coating them with thin metal oxide gel layers. The coated nanocrystals exhibit high dispersibility, stability, and photoluminescence quantum yield. The versatility of this approach is demonstrated by using different metal oxide coatings.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Dmitry N. Dirin, Anna Vivani, Marios Zacharias, Taras V. Sekh, Ihor Cherniukh, Sergii Yakunin, Federica Bertolotti, Marcel Aebli, Richard D. Schaller, Alexander Wieczorek, Sebastian Siol, Claudia Cancellieri, Lars P. H. Jeurgens, Norberto Masciocchi, Antonietta Guagliardi, Laurent Pedesseau, Jacky Even, Maksym V. Kovalenko, Maryna I. Bodnarchuk
Summary: The search for nontoxic alternatives to lead halide perovskites (LHPs) has revealed that the properties of LHPs can only be achieved in their closest Sn(II) and Ge(II) analogues, despite their tendency to oxidize. A judicious choice of chemistry led to the development of formamidinium tin iodide (FASnI3) with a power conversion efficiency of 14.81% in photovoltaic devices. The synthesis of colloidal FASnI3 NCs with reduced Sn(IV) concentration allowed for the investigation of their intrinsic structural and optical properties, showing characteristics distinct from bulk FASnI3.
Article
Biochemistry & Molecular Biology
Thilini H. Gamage, Herwig Grabmayr, Ferdinand Horvath, Marc Fahrner, Doriana Misceo, William Edward Louch, Gjermund Gunnes, Helen Pullisaar, Janne Elin Reseland, Staale Petter Lyngstadaas, Asbjorn Holmgren, Silja S. Amundsen, Petr Rathner, Linda Cerofolini, Enrico Ravera, Heinrich Krobath, Claudio Luchinat, Thomas Renger, Norbert Mueller, Christoph Romanin, Eirik Frengen
Summary: Stormorken syndrome is a multiorgan hereditary disease caused by dysfunction of the endoplasmic reticulum Ca2+ sensor protein STIM1. The R304W mutation in STIM1, which destabilizes and extends its C terminus, leads to constitutive binding to Orai1 and activation of CRAC channel.
