Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives

Effects of avermectin on immune function and oxidative stress in the pigeon spleen

(2014) Ci Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Enhancement of Herboxidiene Production in Streptomyces chromofuscus ATCC 49982

(2014) Amit Kumar Jha et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis

(2013) Fei He et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain

(2013) Jian-Bo Wang et al.   BIOTECHNOLOGY LETTERS

Avermectin induced inflammation damage in king pigeon brain

(2013) Li-Jie Chen et al.   CHEMOSPHERE

Avermectin induced liver injury in pigeon: Mechanisms of apoptosis and oxidative stress

(2013) Wen-Jun Zhu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Characterization of SAV7471, a TetR-Family Transcriptional Regulator Involved in the Regulation of Coenzyme A Metabolism in Streptomyces avermitilis

(2013) Y. Liu et al.   JOURNAL OF BACTERIOLOGY

Streptomycin resistance-aided genome shuffling to improve doramectin productivity of Streptomyces avermitilis NEAU1069

(2013) Ji Zhang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

(2013) Haruo Ikeda et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Spiroketal Formation and Modification in Avermectin Biosynthesis Involves a Dual Activity of AveC

(2013) Peng Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

(2013) G. Liu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

First report of anthelmintic resistance in Haemonchus contortus in alpacas in Australia

(2013) Abdul Jabbar et al.   Parasites & Vectors

A Novel TetR Family Transcriptional Regulator, SAV576, Negatively Controls Avermectin Biosynthesis in Streptomyces avermitilis

(2013) Jia Guo et al.   PLoS One

Structure and function of a TetR family transcriptional regulator, SbtR, fromthermus thermophilusHB8

(2013) Yoshihiro Agari et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The efficacy of avermectins (ivermectin, doramectin and abamectin) as treatments for infestation with the tick Haemaphysalis longicornis on rabbits in Korea

(2013) Huong Thi Thanh Doan et al.   VETERINARY PARASITOLOGY

Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains

(2013) Xuejin Zhao et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Production of Avermectin B1b From Streptomyces avermitilis 41445 by Batch Submerged Fermentation

(2013) Samia Siddique et al.   Jundishapur Journal of Microbiology

An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction

(2013) Amit Kumar Chaudhary et al.   Biomed Research International

Anthelmintic Avermectins Kill Mycobacterium tuberculosis, Including Multidrug-Resistant Clinical Strains

(2012) L. E. Lim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Extra cytoplasmic function σ factor activation

(2012) Theresa D Ho et al.   CURRENT OPINION IN MICROBIOLOGY

Avermectin Use in Aquaculture

(2012) Tor E. Horsberg   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Effectiveness of emamectin benzoate for treatment of Lepeophtheirus salmonis on farmed Atlantic salmon Salmo salar in the Bay of Fundy, Canada

(2012) PG Jones et al.   DISEASES OF AQUATIC ORGANISMS

Evolutionary engineering of Saccharomyces cerevisiae for efficient aerobic xylose consumption

(2012) Gionata Scalcinati et al.   FEMS YEAST RESEARCH

Glutamate-gated Chloride Channels

(2012) Adrian J. Wolstenholme   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production

(2012) Peng Yin et al.   Journal of Proteomics

Natural Variation in a Chloride Channel Subunit Confers Avermectin Resistance in C. elegans

(2012) R. Ghosh et al.   SCIENCE

Anthelmintic resistance in sheep flocks in Ontario, Canada

(2012) L.C. Falzon et al.   VETERINARY PARASITOLOGY

Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis

(2011) Jingfan Qiu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Production of doramectin by rational engineering of the avermectin biosynthetic pathway

(2011) Jian-Bo Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis

(2011) Libin Jiang et al.   BIOTECHNOLOGY LETTERS

Inactivation of the positive LuxR-type oligomycin biosynthesis regulators OlmRI and OlmRII increases avermectin production in Streptomyces avermitilis

(2011) Qing Yu et al.   CHINESE SCIENCE BULLETIN

Enhancement of pradimicin production in Actinomadura hibisca P157-2 by metabolic engineering

(2011) Sarita Paudel et al.   MICROBIOLOGICAL RESEARCH

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis

(2011) K. T. Miyamoto et al.   MICROBIOLOGY-SGM

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

(2011) Gilles P. van Wezel et al.   NATURAL PRODUCT REPORTS

Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

(2011) Andy CRUMP et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis

(2011) S. Kitani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Doramectin resistance in Haemonchus contortus on an alpaca farm in Belgium

(2011) C. Sarre et al.   VETERINARY PARASITOLOGY

Enhancement of avermectin and ivermectin production by overexpression of the maltose ATP-binding cassette transporter in Streptomyces avermitilis

(2010) Meng Li et al.   BIORESOURCE TECHNOLOGY

Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains

(2010) Lili Li et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis

(2010) Y. Zhuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improvement in doxorubicin productivity by overexpression of regulatory genes in Streptomyces peucetius

(2010) Sailesh Malla et al.   RESEARCH IN MICROBIOLOGY

Identification of avermectin-high-producing strains by high-throughput screening methods

(2009) Hong Gao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis

(2009) Shigeru Kitani et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

New ventures in the chemistry of avermectins

(2009) Thomas Pitterna et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology

(2009) Hong Gao et al.   BIORESOURCE TECHNOLOGY

Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides

(2009) Sushila Maharjan et al.   BIOTECHNOLOGY LETTERS

Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis

(2009) Xuejin Zhao et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Identification and Functional Characterization of an afsR Homolog Regulatory Gene from Streptomyces venezuelae ATCC 15439

(2009) Jae Kyung Sohng   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Functional Expression of SAV3818, a Putative TetR-Family Transcriptional Regulatory Gene from Streptomyces avermitilis, Stimulates Antibiotic Production in Streptomyces Species

(2009) Eung-Soo Kim   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

(2009) Jia Guo et al.   MOLECULAR GENETICS AND GENOMICS

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

(2008) Xiuping Lin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165

(2008) Lei Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis

(2008) Meng Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Heterologous expression of metK1-sp and afsR-sp in Streptomyces venezuelae for the production of pikromycin

(2008) Sushila Maharjan et al.   BIOTECHNOLOGY LETTERS

Prevalence of anthelmintic resistance on sheep and goat farms in the southeastern United States

(2008) Sue B. Howell et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

Mycothiol regulates and is regulated by a thiol-specific antisigma factor RsrA and σRin Streptomyces coelicolor

(2008) Joo-Hong Park et al.   MOLECULAR MICROBIOLOGY

The human mitochondrial ribosome recycling factor is essential for cell viability

(2008) Joanna Rorbach et al.   NUCLEIC ACIDS RESEARCH

Ivermectin: 25 years and still going strong

(2007) S. Õmura   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS