Article
Microbiology
Rikako Sato, Satoshi Ara, Harutake Yamazaki, Koji Ishiya, Sachiyo Aburatani, Hiroaki Takaku
Summary: Research on the oleaginous yeast Lipomyces starkeyi mutant sr22 revealed decreased expression of citrate-mediated acyl-CoA synthesis-related genes and highlighted the correlation between gene expression and TAG synthesis. Furthermore, the study on a strain lacking ATP-citrate lyase showed the enzyme's crucial role in cell growth and TAG synthesis in a glucose medium.
Article
Biology
Jingbo Ma, Yang Gu, Peng Xu
Summary: This study reports a systematic approach to improve the biosynthesis of the cannabinoid precursor olivetolic acid in yeast, leading to a significant increase in the production of the acid. The findings provide a baseline for engineering cannabinoids biosynthesis in oleaginous yeast species.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Medicinal
Yongjun Zang, Luyang Tai, Yuanyang Hu, Yu Wang, Hongbin Sun, Xiaoan Wen, Haoliang Yuan, Liang Dai
Summary: A novel macrocyclic compound 2 with potent ACLY inhibitory activity and improved metabolic stability has been identified, highlighting its potential as a lead compound worthy of further study.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Multidisciplinary Sciences
Jordan T. Noe, Beatriz E. Rendon, Anne E. Geller, Lindsey R. Conroy, Samantha M. Morrissey, Lyndsay E. A. Young, Ronald C. Bruntz, Eun J. Kim, Ashley Wise-Mitchell, Mariana Barbosa de Souza Rizzo, Eric R. Relich, Becca Baby, Lance A. Johnson, Hayley C. Affronti, Kelly M. McMasters, Brian F. Clem, Matthew S. Gentry, Jun Yan, Kathryn E. Wellen, Ramon C. Sun, Robert A. Mitchell
Summary: Lactate accumulation plays a key role in the activation of M2 macrophages, promoting histone acetylation, M2 gene transcription, and functional immune suppression. Metabolism of M2 macrophages is dependent on mitochondrial function and the glucose/lactate metabolic pathway.
Review
Cell Biology
Jonathan E. Campbell, Christopher B. Newgard
Summary: Insulin secretion from pancreatic beta-cells is tightly regulated by various factors such as glucose, amino acids, fatty acids, metabolites, etc., which is crucial for understanding pancreatic dysfunction in diabetes. The complementary actions of insulin and glucagon in mammals tightly regulate metabolic homeostasis, and the dysregulation of these hormones can lead to various pathologies, notably type 2 diabetes.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Article
Immunology
Monica Dominguez, Verena Truemper, Ana Carolina Mota, Bernhard Bruene, Dmitry Namgaladze
Summary: ATP-citrate lyase (ACLY) is a key enzyme involved in metabolic and epigenetic gene regulation. This study investigated the impact of ACLY phosphorylation on its function in human myeloid cells and found that phosphorylation at serine 455 does not affect the enzymatic activity of ACLY. Additionally, loss of ACLY activity may trigger long-term adaptive mechanisms that increase inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sanne G. S. Verberk, Hendrik J. P. van der Zande, Jeroen Baardman, Kyra E. de Goede, Karl J. Harber, Eelco D. Keuning, Joost M. Lambooij, Frank Otto, Anna Zawistowska-Deniziak, Helga E. de Vries, Menno P. J. de Winther, Bruno Guigas, Jan Van den Bossche
Summary: Research indicates that despite enhanced inflammatory responses in vitro, deficiency of macrophage Acly does not worsen acute and chronic inflammatory responses in vivo. Myeloid-specific Acly deletion has limited impact on inflammation and overall metabolic homeostasis in inflammatory disorders like multiple sclerosis and obesity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Meng Zhang, Ruyi Peng, Haizhou Wang, Zhenwei Yang, Hailin Zhang, Yangyang Zhang, Meng Wang, Hongling Wang, Jun Lin, Qiu Zhao, Jing Liu
Summary: This study discovered that Nanog can induce cellular dormancy in colorectal cancer cells through the FAO/ACLY-dependent pathway. This finding reveals a specific mechanism governing cellular dormancy in colorectal cancer.
CELL DEATH & DISEASE
(2022)
Review
Immunology
Monica Dominguez, Bernhard Bruene, Dmitry Namgaladze
Summary: Recent studies have shown the profound influence of metabolism on immune responses, particularly through epigenetic regulation of gene expression. ACLY plays a crucial role in the formation of cytosolic acetyl-CoA, supporting de novo lipogenesis and contributing to epigenetic regulation through histone acetylation. Alternative sources of acetyl-CoA also play a role in metabolic and epigenetic regulation in immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Mohamed M. Elseweidy, Alaa S. Elawady, Mohammed S. Sobh, Gehad M. Elnagar
Summary: The study aimed to investigate the metabolic effects of lycopene (LYC) and atorvastatin (ATOR) in a diabetic hyperlipidemic rat model. The results showed that LYC had better effects on the studied biomarkers, indicating its potential as a natural therapeutic agent for hyperlipidemia.
Article
Cell Biology
Yuan Yao, Jiaming Shi, Chunlai Zhang, Wei Gao, Ning Huang, Yaobei Liu, Weiwen Yan, Yingguang Han, Wenjuan Zhou, Liang Kong
Summary: Hyperglycemia-induced aberrant glucose metabolism is a causative factor of neurodegeneration and cognitive impairment in diabetes mellitus (DM) patients. The pyruvate dehydrogenase kinase (PDK)-lactic acid axis and histone acetylation modification play important roles in the regulation of PDK1 expression under high glucose conditions. Overexpression of PDK1 can protect against hyperglycemia-induced neuronal injury and cognitive impairment in diabetic mice.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Christoph Trautwein, Laimdota Zizmare, Irina Maurer, Benjamin Bender, Bjorn Bayer, Ulrike Ernemann, Marcos Tatagiba, Stefan J. Grau, Bernd J. Pichler, Marco Skardelly, Ghazaleh Tabatabai
Summary: This study presents a valuable resource for analyzing tissue metabolites in diffuse glioma patients, revealing the modulations of metabolites by IDH1 mutation, histology, and tumor treatments. Furthermore, tissue metabolites were found to correlate with patient survival, potentially serving as prognostic and surrogate biomarkers in future clinical studies.
Article
Biochemistry & Molecular Biology
Ying Zhan, Wei Qiao, Bolong Yi, Xinyu Yang, Miaomiao Li, Lu Sun, Lian Ji, Peng Su, Xin Wang, Furong Zhang, Rui Zhang, Mingjun Gao, Wujun Zhao, Yichen Song
Summary: This study found that TMEM198B promotes the malignant progression of glioma by regulating lipid metabolism reprogramming and remodeling immune microenvironment. TMEM198B increases PLAGL2 expression, which activates ACLY and ELOVL6, influencing the behavior of glioma cells. Additionally, TMEM198B promotes M2 polarization of macrophages via glioma-derived exosomes, further facilitating immune escape of glioma cells.
Article
Medicine, Research & Experimental
Mohamed M. Elseweidy, Ahmed E. Elesawy, Mohammed S. Sobh, Gehad M. Elnagar
Summary: High-fructose intake can induce non-alcoholic fatty liver disease (NAFLD) and hyperuricemia. Ellagic acid can alleviate these conditions through the activation of CTRP3 and inhibition of ACL activities, showing more remarkable effects than allopurinol.
Article
Cell Biology
Chong Zhang, Xiang-Yu Wang, Peng Zhang, Tao-Chen He, Jia-Hao Han, Rui Zhang, Jing Lin, Jie Fan, Lu Lu, Wen-Wei Zhu, Hu-Liang Jia, Ju-Bo Zhang, Jin-Hong Chen
Summary: This study identified HSPC111 as a key gene in promoting pre-metastatic niche formation and colorectal cancer liver metastasis (CRLM). HSPC111 altered the lipid metabolism of cancer-associated fibroblasts (CAFs), leading to the formation of a favorable microenvironment for cancer metastasis. This study suggests that targeting HSPC111 may be a potential therapeutic strategy for preventing CRLM.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Zhu Wang, Mei Zhangna, Zhe Chi, Guang-Lei Liu, Zhen-Ming Chi
Summary: This study successfully produced a high yield of liamocins through gene mutation and overexpression. The overexpressed genes promoted liamocins biosynthesis and sugar transport. Massoia lactone prepared from liamocins showed promising antifungal activity.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Engineering, Marine
Li Yuan, Hong-Qian Zhang, Zhe Chi, Guang-Lei Liu, Zhen-Ming Chi
Summary: In this study, it was found that stable nanemulsions loaded with Massoia lactone could be prepared using specific ingredients. The obtained nanemulsions showed high anti-fungal and free radical scavenging activities.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Shun Guo, Wang Ding, Minkyung Kwak, Guanglei Liu, Haixia Liu, Xiaonong Cheng, Yang Zhao, Xinqing Zhao
Summary: A novel multiphase Zr-30Ti-7Nb-4Sn alloy consisting of beta, alpha' and alpha '' phases was designed and fabricated to investigate the mechanical mechanisms responsible for the deformation behavior in multiphase Zr-based alloys involving two different martensites. The results reveal that extensive beta ->alpha '' stress-induced martensitic (SIM) transformation and the reorientation of pre-existing alpha '' martensitic variants occur during loading. Incomplete reverse alpha ''->beta SIM transformation takes place during unloading, leading to residual macroscopic strain in the specimen.
MATERIALS TODAY ADVANCES
(2022)
Article
Microbiology
Cun-Cui Kong, Xin Wei, Guang-Lei Liu, Zhen-Ming Chi, Zhe Chi
Summary: In this study, the strain Aureobasidium melanogenum HN6.2 was genetically engineered to enhance siderophore production, ornithine synthesis, and putrescine production. The overexpression of specific genes successfully increased the yields of ornithine and putrescine, making this strain a promising candidate for industrial applications.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Green & Sustainable Science & Technology
Sha-Sha Song, Bai-Chuan Tian, Hao Chen, Zhe Chi, Guang-Lei Liu, Zhen-Ming Chi
Summary: This study found that a fungal strain can accumulate high levels of lipids from xylose obtained from corn cobs and produce biodiesel with better properties than the standard, showing high potential in renewable fuel industries.
Article
Metallurgy & Metallurgical Engineering
Shun Guo, Hui-hui Zhang, Min-kyung Kwak, Wang Ding, Guang-lei Liu, Wen Ma, Hai-xia Liu, Qing-kun Meng, Xin-qing Zhao
Summary: The mechanisms responsible for deformation behavior in Nb/NiTi composite during pre-straining were systematically investigated. It was found that the composite experiences elastic elongation, slight plastic deformation, and stress-induced martensitic transformation during loading, while the deformation mechanisms during unloading mainly involve elastic recovery, compression deformation, and incomplete reverse SIM transformation.
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
(2022)
Article
Genetics & Heredity
Dengying Liu, Zhong Xu, Wei Zhao, Shiyi Wang, Tuowu Li, Kai Zhu, Guanglei Liu, Xiaoduo Zhao, Qishan Wang, Yuchun Pan, Peipei Ma
Summary: This study investigates the genetic parameters and genetic architectures of six milk production traits in the Shanghai Holstein population. The findings reveal different genetic mechanisms for milk production traits at different stages of lactation, which is significant for molecular breeding.
FRONTIERS IN GENETICS
(2022)
Article
Biotechnology & Applied Microbiology
Xin Wei, Miao Zhang, Guang-Yuan Wang, Guang-Lei Liu, Zhen-Ming Chi, Zhe Chi
Summary: In this study, engineered strains of A. pullulans var. aubasidani were found to be suitable for green fumaric acid production. The ornithine-urea cycle was identified as the key pathway for high level fumarate biosynthesis. Genetic modifications and overexpression led to the development of a strain that produced high yields of fumarate. This research is significant for global sustainable development and carbon neutrality.
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xin Wei, Miao Zhang, Zhe Chi, Guang-Lei Liu, Zhen-Ming Chi
Summary: C-18:2 fatty acids play an important role in the cold and warm growth of psychrotrophic yeast, while C-18:3 fatty acids have no significant effect on cell growth. Additionally, the absence of C-18:2 fatty acids negatively affects cell wall development.
MARINE BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Bin Chen, Guanglei Liu, Minying Wu, Yudong Cao, Haibin Zhong, Jianfeng Shen, Mingxin Ye
Summary: Currently, there is a growing interest in the development of organohydrogel-based wearable flexible electronics (WFEs) due to their superior environmental stability compared to hydrogel-based WFEs. In this study, an efficient strategy is proposed to achieve the quick preparation of organohydrogels by utilizing the high reactivity of eutectic gallium-indium alloy and constructing a glycerol/water binary solvent system. The resulting organohydrogels, named liquid metal-based ion-conducting organohydrogels (LMIOs), demonstrate excellent environmental adaptability, high transparency, and remarkable mechanical properties and self-healing abilities, making them suitable for sensing human motions and applications in skin-attachable devices, robotics, and prosthetics.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Physical
Guang-lei Liu, Wen-chao Xue, Yu-hao Cao, Xiao-xuan Sun, Zhi-qiang Li, Fu-hai Xu, Hai-xia Liu, Jian-zhong Zhou
Summary: This study investigates the effects of laser shock processing (LSP) on the thermal fatigue life and crack growth behavior of the coating and bonding area of the brake disc. The results show that LSP can enhance the thermal fatigue performance of the brake disc repaired by laser cladding.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Materials Science, Multidisciplinary
Guanglei Liu, Wenchao Xue, Yuhao Cao, Zhiqiang Li, Xiaoxuan Sun, Fuhai Xu, Haixia Liu, Jianzhong Zhou
Summary: The effects of Laser Shock Peening (LSP) on the microhardness, residual stress, and microstructure of the Ni60 cladding layer and the combined area of the 20CrNiMo alloy were investigated. The results show that LSP can improve the microhardness, introduce residual compressive stress, and refine the microstructure. The residual compressive stress value is -538 MPa on the surface and -30 MPa at a depth of 2 mm.
JOURNAL OF LASER APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hao Chen, Cun-Cui Kong, Xin Wei, Zhe Chi, Guang-Lei Liu, Zhen-Ming Chi
Summary: In this study, an engineered strain of Aureobasidium melanogenum DFAK-ArgB6 overexpressing the ArgB gene was able to produce 3.0 g/L of L-piperazic acid from glucose during fed-batch fermentation. The yield was 55.6 mg L-piperazic acid/g glucose and the productivity was 24.8 mg/L/h, which is the highest reported so far. The partially purified L-piperazic acid had a purity of 86.4%.
PROCESS BIOCHEMISTRY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Liang Wang, Hui-nan Gu, Lei Zhao, Guang-lei Liu
Summary: This paper studies the motion characteristics and optimal U-turn position of left turn vehicles at signal-controlled intersections. It comprehensively analyzes the impact of left turn with U-turn on traffic flow from the aspects of driving efficiency and queue length.
2022 IEEE 25TH INTERNATIONAL CONFERENCE ON INTELLIGENT TRANSPORTATION SYSTEMS (ITSC)
(2022)
Article
Chemistry, Multidisciplinary
Wei Yao, Jian Tan, Xiaodong Zhu, Guanglei Liu, Zhenglong Xu, Mingxin Ye, Jianfeng Shen
Summary: Inspired by leaf structure, a carbon felt/PVA solar-driven device was developed for the separation of versatile oily wastewater. This device exhibits superior solar energy absorption and vapor release capacity, enabling efficient purification of different types of wastewater, including high concentration oil-water emulsions and acidic/alkaline wastewater.
CELL REPORTS PHYSICAL SCIENCE
(2022)