Exploring the Role of ATP-Citrate Lyase in the Immune System

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

(2020) C. Martinez Calejman et al.   Nature Communications

Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis

(2020) Vugar Azizov et al.   Nature Communications

Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche

(2020) Zhiping Liu et al.   Science Translational Medicine

Metabolism of Natural Killer Cells and Other Innate Lymphoid Cells

(2020) Jingjing Cong   Frontiers in Immunology

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

(2020) Jeroen Baardman et al.   Nature Communications

Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

(2019) Alessandro Carrer et al.   Cancer Discovery

Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy

(2019) Thiago A. Patente et al.   Frontiers in Immunology

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

(2019) Maik Luu et al.   Nature Communications

T cell stemness and dysfunction in tumors are triggered by a common mechanism

(2019) Suman Kumar Vodnala et al.   SCIENCE

Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol

(2019) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

A role for ATP Citrate Lyase in cell cycle regulation during myeloid differentiation

(2019) Jess Rhee et al.   BLOOD CELLS MOLECULES AND DISEASES

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

(2019) Jia Wei et al.   NATURE

Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns

(2019) Saioa Márquez et al.   Cell Reports

Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia and Statin Intolerance

(2019) Ulrich Laufs et al.   Journal of the American Heart Association

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

(2019) Will Bailis et al.   NATURE

Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses

(2019) P. Kent Langston et al.   NATURE IMMUNOLOGY

Increased flux through the mevalonate pathway mediates fibrotic repair without injury

(2019) Jennifer L. Larson-Casey et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis

(2019) Rajni Kumari et al.   Nature Communications

The Untapped Opportunity and Challenge of Immunometabolism: A New Paradigm for Drug Discovery

(2019) Claire Mazumdar et al.   Cell Metabolism

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

(2019) Valentina Pucino et al.   Cell Metabolism

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

Biochemistry of proinflammatory macrophage activation

(2018) Yannic Nonnenmacher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8 + T Cells

(2018) Glenn R. Bantug et al.   IMMUNITY

De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages

(2018) Philipp Stüve et al.   Frontiers in Immunology

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

(2018) Xiaojing Liu et al.   CELL

Metabolism as a guiding force for immunity

(2018) Jonathan Jung et al.   NATURE CELL BIOLOGY

Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation

(2018) Kazuhito Gotoh et al.   Cell Reports

Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase

(2018) Dmitry Namgaladze et al.   Frontiers in Immunology

NOK mediates glycolysis and nuclear PDC associated histone acetylation

(2017) Li Liu   Frontiers in Bioscience-Landmark

Metabolic Regulation of the Immune Humoral Response

(2017) Mark Boothby et al.   IMMUNITY

Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels

(2017) Alessandro Carrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

(2017) Xinjian Li et al.   MOLECULAR CELL

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation

(2017) Kyong-Rim Kieffer-Kwon et al.   MOLECULAR CELL

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

(2017) Sharanya Sivanand et al.   MOLECULAR CELL

ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection

(2017) Anna Vysochan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders

(2017) Stephen L. Pinkosky et al.   TRENDS IN MOLECULAR MEDICINE

ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation

(2017) Suman Das et al.   Cell Reports

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

(2017) Vinay Bulusu et al.   Cell Reports

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet

(2016) Neus Martínez-Micaelo et al.   Disease Models & Mechanisms

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+T lymphocytes

(2016) Nerea Osinalde et al.   MOLECULAR & CELLULAR PROTEOMICS

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

(2016) Petros A. Tyrakis et al.   NATURE

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism

(2016) Supriya Shah et al.   Oncotarget

mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer

(2016) Yaqing Chen et al.   Oncotarget

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

(2016) Steven Zhao et al.   Cell Reports

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Control of macrophage metabolism and activation by mTOR and Akt signaling

(2015) Anthony J. Covarrubias et al.   SEMINARS IN IMMUNOLOGY

Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1

(2015) Yusuke Endo et al.   Cell Reports

Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process

(2014) Antero Salminen et al.   AGEING RESEARCH REVIEWS

A key role of the mitochondrial citrate carrier (SLC25A1) in TNFα- and IFNγ-triggered inflammation

(2014) Vittoria Infantino et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Glucose-dependentde NovoLipogenesis in B Lymphocytes

(2014) Fay J. Dufort et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity

(2014) J. Lee et al.   JOURNAL OF IMMUNOLOGY

Acetate Treatment Increases Fatty Acid Content in LPS-Stimulated BV2 Microglia

(2014) Dhaval P. Bhatt et al.   LIPIDS

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages

(2014) Anna C. Pfalzer et al.   PHYSIOLOGICAL GENOMICS

ATP-citrate lyase is essential for macrophage inflammatory response

(2013) Vittoria Infantino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

(2013) Ruiting Lin et al.   MOLECULAR CELL

ATP citrate lyase knockdown impacts cancer stem cells in vitro

(2013) J-i Hanai et al.   Cell Death & Disease

ATP-citrate lyase: A mini-review

(2012) Melanie Chypre et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

(2012) N. Zaidi et al.   CANCER RESEARCH

Modulation of Inflammatory Cytokines and Mitogen-activated Protein Kinases by Acetate in Primary Astrocytes

(2012) Mahmoud L. Soliman et al.   Journal of Neuroimmune Pharmacology

Acetate supplementation reduces microglia activation and brain interleukin-1β levels in a rat model of Lyme neuroborreliosis

(2012) Catherine A Brissette et al.   Journal of Neuroinflammation

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways

(2011) Jun-ichi Hanai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis

(2010) Stuart F. W. Kendrick et al.   HEPATOLOGY

Adaptive immunity

(2010) Francisco A. Bonilla et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Leptin Contributes to the Adaptive Responses of Mice to High-Fat Diet Intake through Suppressing the Lipogenic Pathway

(2009) Lei Jiang et al.   PLoS One

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer

(2008) T. Migita et al.   CANCER RESEARCH