Microbial and fungal protease inhibitors—current and potential applications

Proteases as Anti-Cancer Targets - Molecular and Biological Basis for Development of Inhibitor-Like Drugs Against Cancer

(2012) A. Bialas et al.   Anti-Cancer Agents in Medicinal Chemistry

Subsite specificity of anthrax lethal factor and its implications for inhibitor development

(2011) Feng Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Proteasomes with Naturally Occurring Compounds in Cancer Treatment

(2011) V. Cecarini et al.   CURRENT CANCER DRUG TARGETS

Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives

(2011) D. Chen et al.   CURRENT CANCER DRUG TARGETS

Aspartic Protease Inhibitors as Potential Anti-Candida albicans Drugs: Impacts on Fungal Biology, Virulence and Pathogenesis

(2011) L. A. Braga-Silva et al.   CURRENT MEDICINAL CHEMISTRY

Bactericidal synergy of lysostaphin in combination with antimicrobial peptides

(2011) A. P. Desbois et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Natural Products from Garcinia brasiliensis as Leishmania Protease Inhibitors

(2011) Ivan O. Pereira et al.   JOURNAL OF MEDICINAL FOOD

Management of type 2 diabetes: new and future developments in treatment

(2011) Abd A Tahrani et al.   LANCET

Fungal Proteases and Their Pathophysiological Effects

(2011) Iwona Yike   MYCOPATHOLOGIA

Efficacy of Bacillus thuringiensis Cry3Aa protoxin and protease inhibitors against coleopteran storage pests

(2011) Brenda Oppert et al.   PEST MANAGEMENT SCIENCE

Structure-based development of specific inhibitors for individual cathepsins and their medical applications

(2011) Nobuhiko KATUNUMA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Review article: specifically targeted anti-viral therapy for hepatitis C - a new era in therapy

(2010) C. M. Lange et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Aliskiren in the Management of Hypertension

(2010) Vivencio Barrios et al.   American Journal of Cardiovascular Drugs

Proteins with antifungal properties and other medicinal applications from plants and mushrooms

(2010) Jack H. Wong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Yeast-hybrid based high-throughput assay for identification of anthrax lethal factor inhibitors

(2010) Joungmok Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plant cystatins

(2010) Meriem Benchabane et al.   BIOCHIMIE

Metallo-aminopeptidase inhibitors

(2010) Artur Mucha et al.   BIOCHIMIE

Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease

(2010) Christian Beaulieu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sortase transpeptidases: Insights into mechanism, substrate specificity, and inhibition

(2010) Kathleen W. Clancy et al.   BIOPOLYMERS

Production of heterologous proteins in plants: Strategies for optimal expression

(2010) Priti N Desai et al.   BIOTECHNOLOGY ADVANCES

Matrix Metalloproteinase Inhibitors

(2010) György Dormán et al.   DRUGS

Protease inhibitors as prophylaxis against leishmaniasis: new hope from the major surface protease gp63

(2010) Martin Olivier et al.   Future Medicinal Chemistry

Secreted Aspergillus fumigatus Protease Alp1 Degrades Human Complement Proteins C3, C4, and C5

(2010) J. Behnsen et al.   INFECTION AND IMMUNITY

Protease inhibitors: A panacea?

(2010) Soghra Khatun Haq et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Recombinant protease inhibitors for herbivore pest control: a multitrophic perspective

(2010) U. Schluter et al.   JOURNAL OF EXPERIMENTAL BOTANY

Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy

(2010) Katrien Brak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thrombin-activatable fibrinolysis inhibitor is degraded by Salmonella enterica and Yersinia pestis

(2010) M. VALLS SERÓN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Expression of a barley cystatin gene in maize enhances resistance against phytophagous mites by altering their cysteine-proteases

(2010) Laura Carrillo et al.   PLANT CELL REPORTS

Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant

(2009) Kristina Berggren et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity relationship studies of a novel series of anthrax lethal factor inhibitors

(2009) Sherida L. Johnson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Substrate based peptide aldehyde inhibits bacterial type I signal peptidase

(2009) Peter Buzder-Lantos et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase

(2009) David A. Harris et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitive Effects of Alkyl Gallates on Hyaluronidase and Collagenase

(2009) Florin BARLA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The Urokinase Plasminogen Activator System: A Target for Anti-Cancer Therapy

(2009) Salvatore Ulisse et al.   CURRENT CANCER DRUG TARGETS

Cruzipain, the Major Cysteine Protease of Trypanosoma cruzi: A Sulfated Glycoprotein Antigen as Relevant Candidate for Vaccine Development and Drug Target. A Review

(2009) Vilma Duschak et al.   CURRENT MEDICINAL CHEMISTRY

Cathepsin K inhibitors for osteoporosis and potential off-target effects

(2009) Dieter Brömme et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors

(2009) Hui-Min Wang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Macrocypins, a family of cysteine protease inhibitors from the basidiomyceteMacrolepiota procera

(2009) Jerica Sabotič et al.   FEBS Journal

The gingipains: scissors and glue of the periodontal pathogen,Porphyromonas gingivalis

(2009) Rebecca E Fitzpatrick et al.   Future Microbiology

Evaluation of Pseudomonas aeruginosa staphylolysin (LasA protease) in the treatment of methicillin-resistant Staphylococcus aureus endophthalmitis in a rat model

(2009) Irina S. Barequet et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Major Surface Protease of Trypanosomatids: One Size Fits All?

(2009) C. Yao   INFECTION AND IMMUNITY

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

(2009) Nataša Obermajer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Quality Control of Cytoplasmic Membrane Proteins in Escherichia coli

(2009) Y. Akiyama   JOURNAL OF BIOCHEMISTRY

Versatile Loops in Mycocypins Inhibit Three Protease Families

(2009) Miha Renko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two approaches to discovering and developing new drugs for Chagas disease

(2009) JH McKerrow et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

A novel Ecotin-Ubiquitin-Tag (ECUT) for efficient, soluble peptide production in the periplasm of Escherichia coli

(2009) Michael Paal et al.   Microbial Cell Factories

Purification and characterization of a clostripain-like protease from a recombinant Clostridium perfringens culture

(2009) S. Manabe et al.   MICROBIOLOGY-SGM

Trypsin-specific inhibitors from the basidiomycete Clitocybe nebularis with regulatory and defensive functions

(2009) P. Avanzo et al.   MICROBIOLOGY-SGM

Cryptococcus neoformansSite-2 protease is required for virulence and survival in the presence of azole drugs

(2009) Clara M. Bien et al.   MOLECULAR MICROBIOLOGY

MEROPS: the peptidase database

(2009) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Molecular cloning, over expression, and activity studies of a peptidic HIV-1 protease inhibitor: Designed synthetic gene to functional recombinant peptide

(2009) Vinod Vathipadiekal et al.   PEPTIDES

Approaches for refining heterologous protein production in filamentous fungi

(2009) Ruchika Sharma et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Plant Proteases: From Phenotypes to Molecular Mechanisms

(2008) Renier A. L. van der Hoorn   Annual Review of Plant Biology

Design of Potent Aspartic Protease Inhibitors to Treat Various Diseases

(2008) Jeffrey-Tri Nguyen et al.   ARCHIV DER PHARMAZIE

Proteolytic inactivation of tissue factor pathway inhibitor by bacterial omptins

(2008) T. H. Yun et al.   BLOOD

Influence of parasite encoded inhibitors of serine peptidases in early infection of macrophages withLeishmania major

(2008) Sylvain C. P. Eschenlauer et al.   CELLULAR MICROBIOLOGY

The Thermolysin Family (M4) of Enzymes: Therapeutic and Biotechnological Potential

(2008) Olayiwola A. Adekoya et al.   Chemical Biology & Drug Design

Cathepsin D—Many functions of one aspartic protease

(2008) Petr Benes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Development of protease inhibitors for protozoan infections

(2008) James H McKerrow et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Discovery and Development of Anthrax Lethal Factor Metalloproteinase Inhibitors

(2008) Benjamin Turk   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Immunity Protein Protects Colicin E2 from OmpT Protease

(2008) D. Duche et al.   JOURNAL OF BIOCHEMISTRY

Evolution of Peptidase Diversity

(2008) Michael J. Page et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteases: Multifunctional Enzymes in Life and Disease

(2008) Carlos López-Otín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of cathepsin X in the migration and invasiveness of T lymphocytes

(2008) Z. Jevnikar et al.   JOURNAL OF CELL SCIENCE

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

(2008) Fabrizio Trinchese et al.   JOURNAL OF CLINICAL INVESTIGATION

Corruption of Innate Immunity by Bacterial Proteases

(2008) Jan Potempa et al.   Journal of Innate Immunity

Biochemical properties and primary structure of elastase inhibitor AFUEI from Aspergillus fumigatus

(2008) Y. Okumura et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Secreted Proteases from Dermatophytes

(2008) Michel Monod   MYCOPATHOLOGIA

PMAP: databases for analyzing proteolytic events and pathways

(2008) Yoshinobu Igarashi et al.   NUCLEIC ACIDS RESEARCH

The Degradome database: mammalian proteases and diseases of proteolysis

(2008) V. Quesada et al.   NUCLEIC ACIDS RESEARCH

Sortase as a Target of Anti-Infective Therapy

(2008) A. W. Maresso et al.   PHARMACOLOGICAL REVIEWS

Plant cysteine proteinases: Evaluation of the pharmacological activity

(2008) Carlos E. Salas et al.   PHYTOCHEMISTRY

Preventing unintended proteolysis in plant protein biofactories

(2008) Meriem Benchabane et al.   PLANT BIOTECHNOLOGY JOURNAL

Fungal Effector Protein AVR2 Targets Diversifying Defense-Related Cys Proteases of Tomato

(2008) M. Shabab et al.   PLANT CELL

The Cladosporium fulvum Virulence Protein Avr2 Inhibits Host Proteases Required for Basal Defense

(2008) H. P. van Esse et al.   PLANT CELL

Two cysteine proteinase inhibitors from Arabidopsis thaliana, AtCYSa and AtCYSb, increasing the salt, drought, oxidation and cold tolerance

(2008) Xinxin Zhang et al.   PLANT MOLECULAR BIOLOGY

Helminth pathogen cathepsin proteases: it’s a family affair

(2008) M ROBINSON et al.   TRENDS IN BIOCHEMICAL SCIENCES

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2

(2008) Peter J.M. Steenbakkers et al.  

Novel Inhibitor for Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis and Details of Substrate-recognition Mechanism

(2007) Yue Xu et al.   JOURNAL OF MOLECULAR BIOLOGY