Two approaches to discovering and developing new drugs for Chagas disease

Perspectives on Trypanosoma cruzi–Induced Heart Disease (Chagas Disease)

(2009) Herbert B. Tanowitz et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit

(2009) Chiung-Kuang Chen et al.   PLoS Neglected Tropical Diseases

Synthesis of macrocyclic trypanosomal cysteine protease inhibitors

(2008) Yen Ting Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of protease inhibitors for protozoan infections

(2008) James H McKerrow et al.   CURRENT OPINION IN INFECTIOUS DISEASES

X-ray Structure of 4,4′-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14α-Demethylase (CYP51)

(2008) Ali Nasser Eddine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal compounds for the treatment of parasitic diseases

(2008) Simon P. Fricker et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Identification of a New Class of Nonpeptidic Inhibitors of Cruzain

(2008) Katrien Brak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Relevance of the Diversity among Members of the Trypanosoma Cruzi Trans-Sialidase Family Analyzed with Camelids Single-Domain Antibodies

(2008) Laura Ratier et al.   PLoS One

Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes

(2007) Priyadarshini Jaishankar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS