Interleukin-1α and brain inflammation

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

(2015) Vincent Compan et al.   JOURNAL OF IMMUNOLOGY

Streptococcus pneumoniaeworsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα

(2014) Ádám Dénes et al.   ANNALS OF NEUROLOGY

Secretion of adipocytokines by perivascular adipose tissue near stenotic and non-stenotic coronary artery segments in patients undergoing CABG

(2014) Sandra N. Verhagen et al.   ATHEROSCLEROSIS

Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death

(2014) Hazel England et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1  Released from Dying Cells

(2014) T. Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Systemic Inflammation Impairs Tissue Reperfusion Through Endothelin-Dependent Mechanisms in Cerebral Ischemia

(2014) Katie N. Murray et al.   STROKE

Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection

(2013) Hiramani Dhungana et al.   AGING CELL

Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice

(2013) A. Denes et al.   Disease Models & Mechanisms

Caspase-11: The driving factor for noncanonical inflammasomes

(2013) Elena Viganò et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

(2013) Yue Zheng et al.   IMMUNITY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Inflammation in neurodegenerative diseases - an update

(2013) Sandra Amor et al.   IMMUNOLOGY

Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1  via Caspase-8 in Dendritic Cells

(2013) C. Antonopoulos et al.   JOURNAL OF IMMUNOLOGY

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

(2013) John R. Lukens et al.   NATURE

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

(2013) Stefan Freigang et al.   NATURE IMMUNOLOGY

Overview of the interleukin-1 family of ligands and receptors

(2013) Charles A. Dinarello   SEMINARS IN IMMUNOLOGY

Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

(2013) Cierra N. Casson et al.   PLoS Pathogens

Different Members of the IL-1 Family Come Out in Different Ways: DAMPs vs. Cytokines?

(2013) Sonia Carta et al.   Frontiers in Immunology

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

(2013) Busun Kim et al.   Frontiers in Immunology

Changes in Interleukin-1 alpha serum levels after transplantation of umbilical cord blood cells in a model of perinatal hypoxic-ischemic brain damage

(2012) Katja Rosenkranz et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

(2012) G. B. Fortes et al.   BLOOD

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology

(2012) A. D. Greenhalgh et al.   Disease Models & Mechanisms

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Delayed Administration of Interleukin-1 Receptor Antagonist Reduces Ischemic Brain Damage and Inflammation in Comorbid Rats

(2012) Jesus M Pradillo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neutrophil Cerebrovascular Transmigration Triggers Rapid Neurotoxicity through Release of Proteases Associated with Decondensed DNA

(2012) C. Allen et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1  and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

(2012) L. Bossaller et al.   JOURNAL OF IMMUNOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Global Indicators and Targets for Noncommunicable Diseases

(2012) S. Y. Angell et al.   SCIENCE

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme

(2011) John G. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size

(2011) Ádám Dénes et al.   Journal of Neuroinflammation

Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues

(2011) Nadia M Luheshi et al.   Journal of Neuroinflammation

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

(2011) Inna S. Afonina et al.   MOLECULAR CELL

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Inflammasome activation and IL-1  target IL-1  for secretion as opposed to surface expression

(2011) A. Fettelschoss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A World of Chronic Disease

(2011) S. Reardon   SCIENCE

Influenza Virus Infection Aggravates Stroke Outcome

(2011) Sajjad Muhammad et al.   STROKE

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Platelet interleukin-1  drives cerebrovascular inflammation

(2010) P. Thornton et al.   BLOOD

The Cytokine Response to Human Traumatic Brain Injury: Temporal Profiles and Evidence for Cerebral Parenchymal Production

(2010) Adel Helmy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Necrostatin Decreases Oxidative Damage, Inflammation, and Injury after Neonatal HI

(2010) Frances J Northington et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic Systemic Infection Exacerbates Ischemic Brain Damage via a CCL5 (Regulated on Activation, Normal T-Cell Expressed and Secreted)-Mediated Proinflammatory Response in Mice

(2010) A. Denes et al.   JOURNAL OF NEUROSCIENCE

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sustained IL-1α, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus

(2010) Jaime S Rosa et al.   PEDIATRIC DIABETES

Differential release of chromatin-bound IL-1  discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

(2010) I. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation

(2009) A. Denes et al.   BRAIN BEHAVIOR AND IMMUNITY

Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy

(2009) NM Luheshi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Vascular Smooth Muscle Cell Apoptosis Induces Interleukin-1–Directed Inflammation

(2009) Murray C.H. Clarke et al.   CIRCULATION RESEARCH

Nuclear retention of IL-1α by necrotic cells: A mechanism to dampen sterile inflammation

(2009) Nadia M. Luheshi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Hemin-induced necroptosis involves glutathione depletion in mouse astrocytes

(2008) Melissa D. Laird et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology