Article
Immunology
Ran Zheng, Yiqun Yan, Shaobing Dai, Yang Ruan, Ying Chen, Chenjun Hu, Zhihao Lin, Naijia Xue, Zhe Song, Yi Liu, Baorong Zhang, Jiali Pu
Summary: Inflammasome activation plays a pathogenic role in Parkinson's disease (PD). The up-regulation of the inflammasome adaptor ASC and the formation of ASC specks have been observed in PD brains and models. However, the contribution of ASC specks in propagating inflammasome activation and pathological progression in PD is not fully understood.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Medicine, Research & Experimental
Damien Bertheloot, Carlos W. S. Wanderley, Ayda H. Schneider, Lisa D. J. Schiffelers, Jennifer D. Wuerth, Jan M. P. Toedtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S. Ribeiro, Lea-Marie Jenster, Nathalia Rosero, Yonas M. Tesfamariam, Fernando Q. Cunha, Florian Schmidt, Bernardo S. Franklin
Summary: Inflammasomes are activated by intracellular clues and play important roles in cell death and inflammation. This study demonstrates that a specific antibody can neutralize activated inflammasomes and alleviate inflammatory diseases.
EMBO MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Julie L. Elliott, Ronni Grapenthin, Revathy M. Parameswaran, Zhuohui Xiao, Jeffrey T. Freymueller, Logan Fusso
Summary: Understanding the variability in size and location of large earthquakes along subduction margins is crucial for assessing seismic and tsunami hazards. This study presents a coseismic slip model for the 2021 M8.2 Chignik earthquake and investigates its relationship to previous major events in the Alaska Peninsula region and interseismic coupling. The results suggest that stress changes from a previous event triggered the Chignik earthquake and partially filled an unruptured section along the subduction margin. Variations in coupling and structural characteristics may make the region more prone to nucleating moderate to large earthquakes rather than extremely large ones. The findings also indicate that the recent earthquakes may be part of a long rupture cascade and have increased seismic hazard in the region.
Review
Immunology
Abhinit Nagar, Ravi Bharadwaj, Mohammad Omar Faruk Shaikh, Abhishek Roy
Summary: NLRP3-ASC specks are the hallmark of NLRP3 inflammasome activation, but there is no direct experimental evidence to support this notion.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Nico Wittmann, Neha Mishra, Jana Gramenz, Daniela Kuthning, Ann-Kathrin Behrendt, Lukas Bossaller, Almut Meyer-Bahlburg
Summary: The formation of large intracellular protein aggregates of the inflammasome adaptor ASC is a key step in inflammasome activation and characteristic of autoinflammation. The study investigated the presence of pyroptotic cells in the circulation of oligo- and poly-articular JIA patients, and found that oligo-articular JIA patients showed significantly higher inflammasome activation compared to poly-articular JIA patients. This suggests that inflammasome derived autoinflammation may have a greater influence in oligo-articular JIA patients.
FRONTIERS IN MEDICINE
(2023)
Article
Engineering, Electrical & Electronic
Matthias Noebels, Ian Dobson, Mathaios Panteli
Summary: Research shows that during extreme power outages, cascading effects can be divided into slow and fast phases, with the slow phase being the optimal time for operators to implement mitigation measures. The acceleration of common cascading outages is much lower than that of extreme cascades, indicating the need for ongoing research on mitigation strategies.
IEEE TRANSACTIONS ON POWER SYSTEMS
(2021)
Article
Cell Biology
Tae-Geun Yu, Jeong Seok Cha, Gijeong Kim, Yoo-Kyoung Sohn, Youngki Yoo, Uijin Kim, Ji-Joon Song, Hyun-Soo Cho, Hak-Sung Kim
Summary: Inflammasomes are multi-protein complexes that play a crucial role in host defense against pathogens. The oligomerization degrees of ASC specks regulate caspase-1 activation in the extracellular space.
CELL DEATH DISCOVERY
(2023)
Article
Automation & Control Systems
Zixin Zhong, Wang Chi Chueng, Vincent Y. F. Tan
Summary: Motivated by the need for efficient optimization in online recommender systems, this paper revisits the cascading bandit model and provides theoretical guarantees for TS algorithms in a stochastic combinatorial bandit problem model with partial feedback. The proposed TS algorithms demonstrate superiority over existing UCB-based algorithms in numerical experiments.
JOURNAL OF MACHINE LEARNING RESEARCH
(2021)
Article
Computer Science, Information Systems
Kun Wang
Summary: The C-4-UCB algorithm addresses performance guarantee issues in the contextual combinatorial cascading bandit framework by integrating the online learning algorithm UCB and a conservative mechanism. Experimental results show that compared to C-3-bandit, the regret in known and unknown baseline reward situations is only enlarged by an additive constant term.
Article
Chemistry, Multidisciplinary
Runxiao Zheng, Jing Zhang, Xiaoqing Han, Yunyun Wu, Jiao Yan, Panpan Song, Yanjing Wang, Xiaqing Wu, Haiyuan Zhang
Summary: There is growing evidence suggesting that ambient particulate matter PM2.5 may exacerbate Alzheimer's disease by activating the NLRP3 inflammasome, leading to A beta aggregation and neuronal apoptosis. This correlation was confirmed in a study where intranasal exposure to PM2.5 in mice showed release of ASC specks and cognitive deficits in spatial memory ability.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Geosciences, Multidisciplinary
Fariborz Goodarzi, Somayeh Hosseininejad, Per K. Pedersen, Thomas Gentzis, Hamed Sanei
Summary: The Cretaceous Second White Specks Formation oil shales from Canada were analyzed to determine their composition, depositional environment, and hydrocarbon generating potential. The study identified different depositional facies and found variations in TOC content, boron content, and hydrocarbon potential among the oil shales.
MARINE AND PETROLEUM GEOLOGY
(2022)
Review
Polymer Science
Arnaud Besserer, Sarah Troilo, Pierre Girods, Yann Rogaume, Nicolas Brosse
Summary: Wood is a sought-after renewable resource, with waste wood being used for new material production. However, improvements in legislation and recycling processes are necessary to maximize reuse and enhance recycled wood properties. Innovations in sorting techniques, cleaning processes, and bioremediation are being developed in Europe to address these challenges.
Article
Cell Biology
Omar Escobar-Chavarria, Alejandro Benitez-Guzman, Itzel Jimenez-Vazquez, Jacobo Carrisoza-Urbina, Lourdes Arriaga-Pizano, Sara Huerta-Yepez, Guillermina Baay-Guzman, Jose A. Gutierrez-Pabello
Summary: The necrotic cell death induced by Mycobacterium bovis and the inflammasome activation in bovine macrophages help control bacterial growth.
Article
Gastroenterology & Hepatology
Marcelle de Carvalho Ribeiro, Arvin Iracheta-Vellve, Mrigya Babuta, Charles D. Calenda, Christopher Copeland, Yuan Zhuang, Patrick P. Lowe, Danielle Hawryluk, Donna Catalano, Yeonhee Cho, Bruce Barton, Srinivasan Dasarathy, Craig McClain, Arthur J. McCullough, Mack C. Mitchell, Laura E. Nagy, Svetlana Radaeva, Egil Lien, Douglas T. Golenbock, Gyongyi Szabo
Summary: In severe alcohol-associated hepatitis (AH), chronic alcohol induces NLRP3 inflammasome activation in the liver, while alcohol binge not only activates NLRP3 inflammasome but also increases circulating ex-ASC specks and hepatic ASC aggregates. These ex-ASC specks persist even after alcohol cessation and can trigger liver damage.
Article
Engineering, Industrial
Oded Cats, Anne Mijntje Hijner
Summary: This study aims to develop a network-wide data-driven delay analysis method by constructing a Bayesian network representing the relations between delays in transport networks and proposing informativity indicators for quantifying the spatial extent of delays. The results showed that delays at selected stations are directly informative of delays at many other stations and topological properties of metro stations have limited value in approximating network-wide delay correlations.
RELIABILITY ENGINEERING & SYSTEM SAFETY
(2021)
