The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling

The lock-washer: a reconciliation of the RIG-I activation models

(2014) Shu Zhu et al.   CELL RESEARCH

Phase I Dose-Escalation Study of LCL161, an Oral Inhibitor of Apoptosis Proteins Inhibitor, in Patients With Advanced Solid Tumors

(2014) Jeffrey R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I

(2014) Bin Wu et al.   MOLECULAR CELL

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

(2014) Alys Peisley et al.   NATURE

Crystal Structure of a Complex of NOD1 CARD and Ubiquitin

(2014) Aaron M. Ver Heul et al.   PLoS One

Many players in BCL-2 family affairs

(2014) Tudor Moldoveanu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5

(2014) Stephanie Reikine et al.   Frontiers in Immunology

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

(2013) Kai-En Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces

(2013) Tengchuan Jin et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Therapeutic targeting of NOD1 receptors

(2013) L Moreno et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ubiquitin Regulates Caspase Recruitment Domain-mediated Signaling by Nucleotide-binding Oligomerization Domain-containing Proteins NOD1 and NOD2

(2013) Aaron M. Ver Heul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIP2 activity in inflammatory disease and implications for novel therapeutics

(2013) Janice C. Jun et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

(2013) Qi Qiao et al.   MOLECULAR CELL

Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling

(2013) Tamas Sessler et al.   PHARMACOLOGY & THERAPEUTICS

Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway

(2013) David J. Rickard et al.   PLoS One

Novel Disulfide Bond-Mediated Dimerization of the CARD Domain Was Revealed by the Crystal Structure of CARMA1 CARD

(2013) Tae-ho Jang et al.   PLoS One

Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1

(2013) Tengchuan Jin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Evading apoptosis in cancer

(2013) Kaleigh Fernald et al.   TRENDS IN CELL BIOLOGY

NLRP3 Inflammasome Is a Target for Development of Broad-Spectrum Anti-Infective Drugs

(2012) James D. Thacker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases

(2012) Ricardo G. Correa et al.   BIOSCIENCE REPORTS

AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer

(2012) Melissa K. Brunckhorst et al.   CANCER BIOLOGY & THERAPY

Helical assembly in the death domain (DD) superfamily

(2012) Ryan Ferrao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Regulation of NF-κB by the CARD proteins

(2012) Changying Jiang et al.   IMMUNOLOGICAL REVIEWS

Structural Features of Caspase-Activating Complexes

(2012) Hyun Ho Park   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Promising IAP Antagonist on the Horizon for Clinical Translation

(2012) Simone Fulda   JOURNAL OF MEDICINAL CHEMISTRY

Emerging Role of Ubiquitination in Antiviral RIG-I Signaling

(2012) J. Maelfait et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Inflammasomes in carcinogenesis and anticancer immune responses

(2012) Laurence Zitvogel et al.   NATURE IMMUNOLOGY

A Key Role for the Endothelium in NOD1 Mediated Vascular Inflammation: Comparison to TLR4 Responses

(2012) Timothy Gatheral et al.   PLoS One

Modulation of immune signalling by inhibitors of apoptosis

(2012) Shawn T. Beug et al.   TRENDS IN IMMUNOLOGY

Hydrophenalene–Cr(CO)3 complexes as anti-inflammatory agents based on specific inhibition of NOD2 signalling: a SAR study

(2012) Aroonchai Saiai et al.   MedChemComm

NOD1 and NOD2 Signaling in Infection and Inflammation

(2012) Lilian O. Moreira et al.   Frontiers in Immunology

The Powerstroke and Camshaft of the RIG-I Antiviral RNA Detection Machine

(2011) Luke A.J. O'Neill et al.   CELL

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Caspase-2: the orphan caspase

(2011) L Bouchier-Hayes et al.   CELL DEATH AND DIFFERENTIATION

The PIDDosome, DNA-damage-induced apoptosis and beyond

(2011) S Janssens et al.   CELL DEATH AND DIFFERENTIATION

Discovery and Characterization of 2-Aminobenzimidazole Derivatives as Selective NOD1 Inhibitors

(2011) Ricardo G. Correa et al.   CHEMISTRY & BIOLOGY

Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein

(2011) Keiichiro Okuhira et al.   FEBS LETTERS

Polypeptide Modulators of Caspase Recruitment Domain (CARD)-CARD-mediated Protein-Protein Interactions

(2011) Yadira Palacios-Rodríguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CARD-Mediated Autoinhibition of cIAP1's E3 Ligase Activity Suppresses Cell Proliferation and Migration

(2011) Juanita Lopez et al.   MOLECULAR CELL

NLR functions beyond pathogen recognition

(2011) Thomas A Kufer et al.   NATURE IMMUNOLOGY

A comprehensive manually curated protein–protein interaction database for the Death Domain superfamily

(2011) Dongseop Kwon et al.   NUCLEIC ACIDS RESEARCH

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

(2011) Rebecca C. Coll et al.   PLoS One

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

The Holo-Apoptosome: Activation of Procaspase-9 and Interactions with Caspase-3

(2011) Shujun Yuan et al.   STRUCTURE

The death-fold superfamily of homotypic interaction motifs

(2011) Kristof Kersse et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inflammasomes: Caspase-1-Activating Platforms with Critical Roles in Host Defense

(2011) Lieselotte Vande Walle et al.   Frontiers in Microbiology

Expanding role of ubiquitination in NF-κB signaling

(2010) Siqi Liu et al.   CELL RESEARCH

NF-κB signaling pathways regulated by CARMA family of scaffold proteins

(2010) Marzenna Blonska et al.   CELL RESEARCH

Anti-inflammatory AreneChromium Complexes Acting as Specific Inhibitors of NOD2 Signalling

(2010) Harald Bielig et al.   ChemMedChem

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses

(2010) J. T. Tigno-Aranjuez et al.   GENES & DEVELOPMENT

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

(2010) Liwei Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The unpredictable caspase-2: what can it do?

(2010) Helin Vakifahmetoglu-Norberg et al.   TRENDS IN CELL BIOLOGY

Antigen Receptor Signaling to NF- B via CARMA1, BCL10, and MALT1

(2010) M. Thome et al.   Cold Spring Harbor Perspectives in Biology

Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists

(2009) Chudi Ndubaku et al.   ACS Chemical Biology

A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint

(2009) Laura Mondragón et al.   APOPTOSIS

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates

(2009) Pablo Pelegrin et al.   EMBO JOURNAL

Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)

(2009) Eva de Alba   JOURNAL OF BIOLOGICAL CHEMISTRY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Attenuating Smac mimetic compound 3-induced NF-κB activation by luteolin leads to synergistic cytotoxicity in cancer cells

(2009) Lang Bai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Fas–FADD death domain complex structure unravels signalling by receptor clustering

(2009) Fiona L. Scott et al.   NATURE

BH3-only proteins in apoptosis and beyond: an overview

(2009) E Lomonosova et al.   ONCOGENE

Monomer/Dimer Transition of the Caspase-Recruitment Domain of Human Nod1†,‡

(2008) Thiagarajan Srimathi et al.   BIOCHEMISTRY

Inhibition of Nod2 Signaling and Target Gene Expression by Curcumin

(2008) S. Huang et al.   MOLECULAR PHARMACOLOGY

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain

(2008) Jane A Potter et al.   BMC STRUCTURAL BIOLOGY